Exogenous hydrogen sulfide alleviates impairment of central chemoreception induced by prenatal cigarette smoke exposure in neonatal rats

Nitric Oxide ◽  
2015 ◽  
Vol 47 ◽  
pp. S40
Author(s):  
Fang Lei ◽  
Xiang Yan ◽  
Fusheng Zhao ◽  
Senfeng Zhang ◽  
Qilan Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Neonatal Rats ◽  
Central Chemoreception

scholarly journals Impairment of Central Chemoreception in Neonatal Rats Induced by Maternal Cigarette Smoke Exposure during Pregnancy

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137362 ◽  
Author(s):  
Fang Lei ◽  
Xiang Yan ◽  
Fusheng Zhao ◽  
Senfeng Zhang ◽  
Qilan Zhang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Neonatal Rats ◽  
Exposure During Pregnancy ◽  
Central Chemoreception

Hydrogen sulfide alleviates placental injury induced by maternal cigarette smoke exposure during pregnancy in rats

Nitric Oxide ◽  
2018 ◽  
Vol 74 ◽  
pp. 102-111 ◽  
Author(s):  
Fusheng Zhao ◽  
Fang Lei ◽  
Senfeng Zhang ◽  
Xiang Yan ◽  
Wen Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Exposure During Pregnancy

Maternal cigarette smoke exposure disturbs glutamate/GABA balance in pFRG of neonatal rats

2020 ◽  
Vol 274 ◽  
pp. 103383
Author(s):  
Yating Fu ◽  
Fang Lei ◽  
Ji Wang ◽  
Wen Wang ◽  
Yu Zheng
Keyword(s):  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Neonatal Rats

scholarly journals Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats

2018 ◽  
Vol 48 (5) ◽  
pp. 1815-1828 ◽  
Author(s):  
Fusheng Zhao ◽  
Fang Lei ◽  
Xiang Yan ◽  
Senfeng Zhang ◽  
Wen Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Oxidative Damage ◽  
Cigarette Smoke ◽  
Health Hazard ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Related Factor ◽  
Protective Effects ◽  
Nrf2 Pathway ◽  
Redox Imbalance

Background/Aims: Cigarette smoke exposure (CSE) during pregnancy is a well-recognized health hazard that causes placental damage. Hydrogen sulfide (H2S) has been reported to protect multiple organs from injury. However, the protective effects of H2S have not been tested in the placenta. This study aimed to explore the potential of H2S in protecting placenta against oxidative injury induced by CSE during pregnancy and the possible underlying mechanisms. Methods: Pregnant SD rats were randomly divided into 4 groups: NaCl, NaHS (a donor of H2S), CSE and CSE+NaHS. Placental oxidative damage was detected by 8-hydroxy-2-deoxyguanosine (8-OHdG) stain and malondialdehyde (MDA) assay. Placental redox status was assessed by measuring reactive oxygen species (ROS), total antioxidant capacity (T-AOC) and glutathione (GSH) levels, as well as copper/zinc SOD (SOD1), manganese SOD (SOD2), catalase (CAT) and glutathione peroxidase (GPx) activities and expressions. Meanwhile, nuclear factor erythroid 2-related factor 2 (Nrf2) was analyzed by immunohistochemistry, real-time PCR and Western blot. Results: We found that NaHS markedly reduced the elevated levels of 8-OHdG and MDA induced by CSE. Further, NaHS treatment effectively mitigated CSE-induced placental redox imbalance by inhibiting ROS production, restoring T-AOC level, increasing GSH/GSSG ratio, and augmenting SOD1 SOD2, CAT and GPx activities and expressions. More notably, NaHS administration also reversed the aberrant decrease of Nrf2 due to CSE in rat placentas. Conclusion: Our data demonstrate that H2S can protect against CSE-induced placental oxidative damage probably by alleviating redox imbalance via Nrf2 pathway.

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