C34. Oxygen regulation of tumor perfusion unravels the central pressor activity of cell-free human S-nitrosohemoglobin

Nitric Oxide ◽  
2007 ◽  
Vol 17 ◽  
pp. 28
Author(s):  
P. Sonveaux ◽  
O. Feron ◽  
T.J. McMahon ◽  
J.S. Stamler ◽  
M.W. Dewhirst
Keyword(s):  
Oxygen Regulation ◽  
Tumor Perfusion ◽  
Pressor Activity

scholarly journals Oxygen Regulation of Tumor Perfusion by S -Nitrosohemoglobin Reveals a Pressor Activity of Nitric Oxide

2005 ◽  
Vol 96 (10) ◽  
pp. 1119-1126 ◽  
Author(s):  
Pierre Sonveaux ◽  
Andrew M. Kaz ◽  
Stacey A. Snyder ◽  
Rachel A. Richardson ◽  
L. Isabel Cárdenas-Navia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oxygen Regulation ◽  
Tumor Perfusion ◽  
Pressor Activity

Vasopressin analogues modified in positions 2, 3 and 8. Synthesis and biological effects

1983 ◽  
Vol 48 (5) ◽  
pp. 1341-1351 ◽  
Author(s):  
Ivo Bláha ◽  
Danuta Konopinska ◽  
Milan Zaoral
Keyword(s):  
Amino Acid ◽  
Solid Phase ◽  
Biological Effects ◽  
Solution Synthesis ◽  
Antidiuretic Activity ◽  
Pressor Activity ◽  
Vasopressin Analogues

Four vasopressin analogues, modified in positions 2, 3 and 8 were prepared by solid phase as well as solution synthesis. Analogues, containing a D-amino acid in position 3, exhibit a low but markedly specific antidiuretic activity. Analogues with a D-substituent in position 2 show a more specific pressor activity.

scholarly journals Attenuated Microcirculation in Small Metastatic Tumors in Murine Liver

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 703
Author(s):  
Arturas Ziemys ◽  
Vladimir Simic ◽  
Miljan Milosevic ◽  
Milos Kojic ◽  
Yan Ting Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Liver Metastases ◽  
Clinical Success ◽  
Metastatic Cancer ◽  
In Vivo Studies ◽  
Central Vein ◽  
Tumor Perfusion ◽  
Metastatic Tumors ◽  
Liver Lobule

Metastatic cancer disease is the major cause of death in cancer patients. Because those small secondary tumors are clinically hardly detectable in their early stages, little is known about drug biodistribution and permeation into those metastatic tumors potentially contributing to insufficient clinical success against metastatic disease. Our recent studies indicated that breast cancer liver metastases may have compromised perfusion of intratumoral capillaries hindering the delivery of therapeutics for yet unknown reasons. To understand the microcirculation of small liver metastases, we have utilized computational simulations to study perfusion and oxygen concentration fields in and around the metastases smaller than 700 µm in size at the locations of portal vessels, central vein, and liver lobule acinus. Despite tumor vascularization, the results show that blood flow in those tumors can be substantially reduced indicating the presence of inadequate blood pressure gradients across tumors. A low blood pressure may contribute to the collapsed intratumoral capillary lumen limiting tumor perfusion that phenomenologically corroborates with our previously published in vivo studies. Tumors that are smaller than the liver lobule size and originating at different lobule locations may possess a different microcirculation environment and tumor perfusion. The acinus and portal vessel locations in the lobule were found to be the most beneficial to tumor growth based on tumor access to blood flow and intratumoral oxygen. These findings suggest that microcirculation states of small metastatic tumors can potentially contribute to physiological barriers preventing efficient delivery of therapeutic substances into small tumors.

scholarly journals Oxygen regulation of TET enzymes

FEBS Journal ◽  
2021 ◽  
Author(s):  
Rugile Matuleviciute ◽  
Pedro P. Cunha ◽  
Randall S. Johnson ◽  
Iosifina P. Foskolou
Keyword(s):  
Oxygen Regulation ◽  
Tet Enzymes

scholarly journals Modulator sequences mediate oxygen regulation of CYC1 and a neighboring gene in yeast.

1983 ◽  
Vol 80 (1) ◽  
pp. 151-155 ◽  
Author(s):  
C. V. Lowry ◽  
J. L. Weiss ◽  
D. A. Walthall ◽  
R. S. Zitomer
Keyword(s):  
Oxygen Regulation ◽  
Neighboring Gene

Dynamic Contrast-Enhanced MRI and Fractal Characteristics of Percolation Clusters in Two-Dimensional Tumor Blood Perfusion

1999 ◽  
Vol 121 (5) ◽  
pp. 480-486 ◽  
Author(s):  
O. I. Craciunescu ◽  
S. K. Das ◽  
S. T. Clegg
Keyword(s):  
Tumor Tissue ◽  
Blood Perfusion ◽  
Percolation Cluster ◽  
Three Dimensions ◽  
Invasion Percolation ◽  
Two Dimensional ◽  
Tumor Perfusion ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Fractal Characteristics

Dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool is used to study tumor tissue perfusion. The results are then analyzed using percolation models. Percolation cluster geometry is depicted using the wash-in component of MRI contrast signal intensity. Fractal characteristics are determined for each two-dimensional cluster. The invasion percolation model is used to describe the evolution of the tumor perfusion front. Although tumor perfusion can be depicted rigorously only in three dimensions, two-dimensional cases are used to validate the methodology. It is concluded that the blood perfusion in a two-dimensional tumor vessel network has a fractal structure and that the evolution of the perfusion front can be characterized using invasion percolation. For all the cases studied, the front starts to grow from the periphery of the tumor (where the feeding vessel was assumed to lie) and continues to grow toward the center of the tumor, accounting for the well-documented perfused periphery and necrotic core of the tumor tissue.

scholarly journals Fate and excretion of the pressor activity of vasopressin in rats

1957 ◽  
Vol 138 (1) ◽  
pp. 11-18 ◽  
Author(s):  
S. E. Dicker ◽  
Joan Nunn
Keyword(s):  
Pressor Activity
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