scholarly journals Relationship of Cell‐Free Hemoglobin to Impaired Endothelial Nitric Oxide Bioavailability and Perfusion in Severe Falciparum Malaria

2009 ◽  
Vol 200 (10) ◽  
pp. 1522-1529 ◽  
Author(s):  
Tsin W. Yeo ◽  
Daniel A. Lampah ◽  
Emiliana Tjitra ◽  
Retno Gitawati ◽  
Enny Kenangalem ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Falciparum Malaria ◽  
Free Hemoglobin ◽  
Relationship Of ◽  
Endothelial Nitric Oxide ◽  
Severe Falciparum Malaria ◽  
Nitric Oxide Bioavailability

scholarly journals Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

2010 ◽  
Vol 6 (4) ◽  
pp. e1000868 ◽  
Author(s):  
Tsin W. Yeo ◽  
Daniel A. Lampah ◽  
Emiliana Tjitra ◽  
Retno Gitawati ◽  
Christabelle J. Darcy ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Falciparum Malaria ◽  
Asymmetric Dimethylarginine ◽  
Fatal Outcome ◽  
Severe Falciparum Malaria ◽  
Nitric Oxide Bioavailability

scholarly journals Nifedipine Increases Endothelial Nitric Oxide Bioavailability by Antioxidative Mechanisms

Hypertension ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Reinhard Berkels ◽  
Guido Egink ◽  
Tobias A. Marsen ◽  
Henning Bartels ◽  
Renate Roesen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Bioavailability

scholarly journals Clopidogrel Improves Systemic Endothelial Nitric Oxide Bioavailability in Patients With Coronary Artery Disease

2006 ◽  
Vol 26 (7) ◽  
pp. 1648-1652 ◽  
Author(s):  
Thomas Heitzer ◽  
Volker Rudolph ◽  
Edzard Schwedhelm ◽  
Manuela Karstens ◽  
Karsten Sydow ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Disease ◽  
Endothelial Nitric Oxide ◽  
Nitric Oxide Bioavailability

scholarly journals Asymmetric Dimethylarginine in Adult Falciparum Malaria: Relationships With Disease Severity, Antimalarial Treatment, Hemolysis, and Inflammation

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Bridget E. Barber ◽  
Timothy William ◽  
Matthew J. Grigg ◽  
Uma Parameswaran ◽  
Kim A. Piera ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Asymmetric Dimethylarginine ◽  
Interleukin 10 ◽  
Antimalarial Treatment ◽  
Factors Associated ◽  
Plasma Adma ◽  
No Bioavailability ◽  
Baseline Levels ◽  
Endothelial Nitric Oxide ◽  
Severe Falciparum Malaria

Abstract Background.  Endothelial nitric oxide (NO) bioavailability is impaired in severe falciparum malaria (SM). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (NOS), contributes to endothelial dysfunction and is associated with mortality in adults with falciparum malaria. However, factors associated with ADMA in malaria, including the NOS-substrate l-arginine, hemolysis, and antimalarial treatment, are not well understood. Methods.  In a prospective observational study of Malaysian adults with SM (N = 22) and non-SM (NSM; N = 124) and healthy controls (HCs), we investigated factors associated with plasma ADMA including the effects of antimalarial treatment. Results.  Compared with HCs, ADMA levels were lower in NSM (0.488 µM vs 0.540 µM, P = .001) and in the subset of SM patients enrolled before commencing treatment (0.453 µM [N = 5], P = .068), but levels were higher in SM patients enrolled after commencing antimalarial treatment (0.610 µM [N = 17], P = .026). In SM and NSM, ADMA levels increased significantly to above-baseline levels by day 3. Baseline ADMA was correlated with arginine and cell-free hemoglobin in SM and NSM and inversely correlated with interleukin-10 in NSM. Arginine and the arginine/ADMA ratio (reflective of arginine bioavailability) were lower in SM and NSM compared with HCs, and the arginine/ADMA ratio was lower in SM compared with NSM. Conclusions.  Pretreatment ADMA concentrations and l-arginine bioavailability are reduced in SM and NSM. Asymmetric dimethylarginine increases to above-baseline levels after commencement of antimalarial treatment. Arginine, hemolysis, and posttreatment inflammation all likely contribute to ADMA regulation, with ADMA likely contributing to the reduced NO bioavailability in SM.

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