scholarly journals Functional Differentiation of Memory Retrieval Network in Macaque Posterior Parietal Cortex

Neuron ◽  
2013 ◽  
Vol 77 (4) ◽  
pp. 787-799 ◽  
Author(s):  
Kentaro Miyamoto ◽  
Takahiro Osada ◽  
Yusuke Adachi ◽  
Teppei Matsui ◽  
Hiroko M. Kimura ◽  
...  
Keyword(s):  
Parietal Cortex ◽  
Memory Retrieval ◽  
Posterior Parietal Cortex ◽  
Functional Differentiation ◽  
Posterior Parietal

scholarly journals Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yoonjeong Jeon ◽  
Yun Lim ◽  
Jiwoo Yeom ◽  
Eun-Kyoung Kim
Keyword(s):  
Mental Disorders ◽  
Parietal Cortex ◽  
Metabolic Pathways ◽  
Memory Retrieval ◽  
Posterior Parietal Cortex ◽  
Conditioned Fear ◽  
Fear Memory ◽  
Glutathione Metabolism ◽  
Potential Biomarker ◽  
Posterior Parietal

AbstractFear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent conditioning and retrieval of fear memory. Metabolomic screening among functionally related brain areas provides molecular signatures and biomarkers to improve the treatment of psychopathologies. Herein, we analyzed and compared changes of metabolites in the hippocampus, amygdala, and posterior parietal cortex under the fear retrieval condition. Metabolite profiles of posterior parietal cortex and amygdala were similarly changed after fear memory retrieval. While the retrieval of fear memory perturbed various metabolic pathways, most metabolic pathways that overlapped among the three brain regions had high ranks in the enrichment analysis of posterior parietal cortex. In posterior parietal cortex, the most perturbed pathways were pantothenate and CoA biosynthesis, purine metabolism, glutathione metabolism, and NAD+ dependent signaling. Metabolites of posterior parietal cortex including 4′-phosphopantetheine, xanthine, glutathione, ADP-ribose, ADP-ribose 2′-phosphate, and cyclic ADP-ribose were significantly regulated in these metabolic pathways. These results point to the importance of metabolites of posterior parietal cortex in conditioned fear memory retrieval and may provide potential biomarker candidates for traumatic memory-related mental disorders.

scholarly journals The posterior parietal cortex and subjectively perceived confidence during memory retrieval

2018 ◽  
Vol 25 (8) ◽  
pp. 382-389 ◽  
Author(s):  
Syanah C. Wynn ◽  
Marc P. H. Hendriks ◽  
Sander M. Daselaar ◽  
Roy P. C. Kessels ◽  
Dennis J. L. G. Schutter
Keyword(s):  
Parietal Cortex ◽  
Memory Retrieval ◽  
Posterior Parietal Cortex ◽  
Posterior Parietal

scholarly journals Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory

2021 ◽  
Author(s):  
Yoonjeong Jeon ◽  
Jiwoo Yeom ◽  
Eun-Kyoung Kim
Keyword(s):  
Mental Disorders ◽  
Parietal Cortex ◽  
Metabolic Pathways ◽  
Memory Retrieval ◽  
Posterior Parietal Cortex ◽  
Conditioned Fear ◽  
Fear Memory ◽  
Glutathione Metabolism ◽  
Potential Biomarker ◽  
Posterior Parietal

Abstract Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent conditioning and retrieval of fear memory. Metabolomic screening among functionally related brain areas provides molecular signatures and biomarkers to improve the treatment of psychopathologies. Herein, we analyzed and compared changes of metabolites in the hippocampus, amygdala and posterior parietal cortex under the fear retrieval condition. Metabolite profiles of posterior parietal cortex and amygdala were similarly changed after fear memory retrieval. While the retrieval of fear memory perturbed various metabolic pathways, most metabolic pathways that overlapped among the three brain regions had high ranks in the enrichment analysis of posterior parietal cortex. In posterior parietal cortex, the most perturbed pathways were pantothenate and CoA biosynthesis, purine metabolism, glutathione metabolism, and NAD+ dependent signaling. Metabolites of posterior parietal cortex including 4′-phosphopantetheine, xanthine, glutathione, ADP-ribose, ADP-ribose phosphate, and cyclic ADP-ribose were significantly regulated in these metabolic pathways. These results point to the importance of metabolites of posterior parietal cortex in conditioned fear memory retrieval and may provide potential biomarker candidates for traumatic memory–related mental disorders.

scholarly journals Functional Heterogeneity in Posterior Parietal Cortex Across Attention and Episodic Memory Retrieval

2012 ◽  
Vol 24 (1) ◽  
pp. 49-66 ◽  
Author(s):  
J. Benjamin Hutchinson ◽  
Melina R. Uncapher ◽  
Kevin S. Weiner ◽  
David W. Bressler ◽  
Michael A. Silver ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Parietal Cortex ◽  
Memory Retrieval ◽  
Posterior Parietal Cortex ◽  
Functional Heterogeneity ◽  
Posterior Parietal

scholarly journals Lower neuronal variability in the monkey dorsolateral prefrontal than posterior parietal cortex

2015 ◽  
Vol 114 (4) ◽  
pp. 2194-2203 ◽  
Author(s):  
Xue-Lian Qi ◽  
Christos Constantinidis
Keyword(s):  
Working Memory ◽  
Firing Rate ◽  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Memory Task ◽  
Fano Factor ◽  
Functional Differentiation ◽  
Neuronal Responses ◽  
Dorsolateral Prefrontal ◽  
Posterior Parietal

The dorsolateral prefrontal and posterior parietal cortex are two brain areas involved in cognitive functions such as spatial attention and working memory. When tested with identical tasks, only subtle differences in firing rate are present between neurons recorded in the two areas. In this article we report that major differences in neuronal variability characterize the two areas during working memory. The Fano factors of spike counts in dorsolateral prefrontal neurons were consistently lower than those of the posterior parietal cortex across a range of tasks, epochs, and conditions in the same monkeys. Variability differences were observed despite minor differences in firing rates between the two areas in the tasks tested and higher overall firing rate in the prefrontal than in the posterior parietal sample. Other measures of neuronal discharge variability, such as the coefficient of variation of the interspike interval, displayed the same pattern of lower prefrontal variability. Fano factor values were negatively correlated with performance in the working memory task, suggesting that higher neuronal variability was associated with diminished task performance. The results indicate that information involving remembered stimuli is more reliably represented in the prefrontal than the posterior parietal cortex based on the variability of neuronal responses, and suggest functional differentiation between the two areas beyond differences in firing rate.

Posterior parietal cortex mediates encoding processes in change blindness

2009 ◽  
Author(s):  
Philip Tseng ◽  
Cassidy Sterling ◽  
Adam Cooper ◽  
Bruce Bridgeman ◽  
Neil G. Muggleton ◽  
...  
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Change Blindness ◽  
Posterior Parietal

The Grasp Cell Hypothesis: Near-miss effect points to common neurological machinery in posterior parietal cortex for controllable objects and concepts

2018 ◽  
Author(s):  
Imogen M Kruse
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Near Miss ◽  
Illusion Of Control ◽  
Gambling Behaviour ◽  
Drug Seeking ◽  
Spatial Influence ◽  
Reward Probability ◽  
Posterior Parietal ◽  
Action Value

The near-miss effect in gambling behaviour occurs when an outcome which is close to a win outcome invigorates gambling behaviour notwithstanding lack of associated reward. In this paper I postulate that the processing of concepts which are deemed controllable is rooted in neurological machinery located in the posterior parietal cortex specialised for the processing of objects which are immediately actionable or controllable because they are within reach. I theorise that the use of a common machinery facilitates spatial influence on the perception of concepts such that the win outcome which is 'almost complete' is perceived as being 'almost within reach'. The perceived realisability of the win increases subjective reward probability and the associated expected action value which impacts decision-making and behaviour. This novel hypothesis is the first to offer a neurological model which can comprehensively explain many empirical findings associated with the near-miss effect as well as other gambling phenomena such as the ‘illusion of control’. Furthermore, when extended to other compulsive behaviours such as drug addiction, the model can offer an explanation for continued drug-seeking following devaluation and for the increase in cravings in response to perceived opportunity to self-administer, neither of which can be explained by simple reinforcement models alone. This paper therefore provides an innovative and unifying perspective for the study and treatment of behavioural and substance addictions.

Sign in / Sign up

Export Citation Format

Share Document