scholarly journals Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA

Neuron ◽  
2008 ◽  
Vol 59 (2) ◽  
pp. 288-297 ◽  
Author(s):  
Billy T. Chen ◽  
M. Scott Bowers ◽  
Miquel Martin ◽  
F. Woodward Hopf ◽  
Anitra M. Guillory ◽  
...  
Keyword(s):  
Self Administration ◽  
Natural Reward ◽  
Cocaine Infusion

scholarly journals Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior

2021 ◽  
Vol 12 ◽  
Author(s):  
Fushen Zhang ◽  
Shihao Huang ◽  
Haiyan Bu ◽  
Yu Zhou ◽  
Lixiang Chen ◽  
...  
Keyword(s):  
Spontaneous Recovery ◽  
Time Window ◽  
Mammalian Target Of Rapamycin ◽  
Self Administration ◽  
Mtor Inhibition ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Previously Treated ◽  
Cocaine Infusion ◽  
Paired Tone

Drug addiction is considered maladaptive learning, and drug-related memories aroused by the presence of drug related stimuli (drug context or drug-associated cues) promote recurring craving and reinstatement of drug seeking. The mammalian target of rapamycin signaling pathway is involved in reconsolidation of drug memories in conditioned place preference and alcohol self-administration (SA) paradigms. Here, we explored the effect of mTOR inhibition on reconsolidation of addiction memory using cocaine self-administration paradigm. Rats received intravenous cocaine self-administration training for 10 consecutive days, during which a light/tone conditioned stimulus was paired with each cocaine infusion. After acquisition of the stable cocaine self-administration behaviors, rats were subjected to nosepoke extinction (11 days) to extinguish their behaviors, and then received a 15 min retrieval trial with or without the cocaine-paired tone/light cue delivery or without. Immediately or 6 h after the retrieval trial, rapamycin (10 mg/kg) was administered intraperitoneally. Finally, cue-induced reinstatement, cocaine-priming-induced reinstatement and spontaneous recovery of cocaine-seeking behaviors were assessed in rapamycin previously treated animals, respectively. We found that rapamycin treatment immediately after a retrieval trial decreased subsequent reinstatement of cocaine seeking induced by cues or cocaine itself, and these effects lasted at least for 28 days. In contrast, delayed intraperitoneal injection of rapamycin 6 h after retrieval or rapamycin injection without retrieval had no effects on cocaine-seeking behaviors. These findings indicated that mTOR inhibition within the reconsolidation time-window impairs the reconsolidation of cocaine associated memory, reduces cocaine-seeking behavior and prevents relapse, and these effects are retrieval-dependent and temporal-specific.

scholarly journals Differential Effects of σ1 Receptor Blockade on Self-Administration and Conditioned Reinstatement Motivated by Cocaine vs Natural Reward

2007 ◽  
Vol 32 (9) ◽  
pp. 1967-1973 ◽  
Author(s):  
Rémi Martin-Fardon ◽  
Tangui Maurice ◽  
Harinder Aujla ◽  
Wayne D Bowen ◽  
Friedbert Weiss
Keyword(s):  
Receptor Blockade ◽  
Self Administration ◽  
Differential Effects ◽  
Natural Reward ◽  
Σ1 Receptor

Collection of Ego-Centered Network Data with Computer-Assisted Interviews

Methodology ◽  
2006 ◽  
Vol 2 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Joachim Gerich ◽  
Roland Lehner
Keyword(s):  
Survey Methods ◽  
A Priori ◽  
Dynamic Structure ◽  
Computer Assisted ◽  
Network Data ◽  
Great Effort ◽  
Self Administration ◽  
Face To Face ◽  
Full Network

Although ego-centered network data provide information that is limited in various ways as compared with full network data, an ego-centered design can be used without the need for a priori and researcher-defined network borders. Moreover, ego-centered network data can be obtained with traditional survey methods. However, due to the dynamic structure of the questionnaires involved, a great effort is required on the part of either respondents (with self-administration) or interviewers (with face-to-face interviews). As an alternative, we will show the advantages of using CASI (computer-assisted self-administered interview) methods for the collection of ego-centered network data as applied in a study on the role of social networks in substance use among college students.

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