The lumbar spinal cord glial cells actively modulate subcutaneous formalin induced hyperalgesia in the rat

2006 ◽  
Vol 55 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Ming Qin ◽  
Jing-Jie Wang ◽  
Rong Cao ◽  
Hui Zhang ◽  
Li Duan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Glial Cells ◽  
Lumbar Spinal Cord ◽  
Lumbar Spinal

scholarly journals Reactive changes in the rat spinal cord in experimental neuropathy with and without magnetic stimulation

2019 ◽  
Vol 21 (2) ◽  
pp. 166-172
Author(s):  
S A Zhivolupov ◽  
N A Rashidov ◽  
L S Onishchenko ◽  
A Yu Kravchuk ◽  
O V Kostina ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcranial Magnetic Stimulation ◽  
Glial Cells ◽  
Magnetic Stimulation ◽  
Morphological Data ◽  
Lumbar Spinal Cord ◽  
Rat Spinal Cord ◽  
Recovery Processes ◽  
Reactive Changes ◽  
Lumbar Spinal

Performing an experiment in which electronically microscopically studied the nature of reactive changes in the structural thin section of the spinal cord, as well as their dynamics during transcranial magnetic stimulation for 1 month after experimental neuromesis and after compression-ischemic neuropathy of the sciatic nerve. The reported development of compensatory-restorative processes in neurons, glial cells and the microvasculature of the lumbar spinal cord in rats that receive treatment with transcranial magnetic stimulation has been established. It was shown, that in all groups of rats changes in the structures of the lumbar thickening of the rat spinal cord developed in the form of depletion of the cytoplasm, destruction of organelles, changes in the nuclei and development of apoptosis of neurons and glial cells, destruction of the membranes and axial cylinders of myelin fibers. Moreover, these changes are more pronounced in groups after experimental neuromesis. However, in groups of rats, both after compression-ischemic neuropathy and after experimental neuromesis after treatment with transcranial magnetic stimulation, there were signs of the development of recovery processes in the form of intracellular repair of neurons, proliferation of oligodendrocytes, restoration of the structure of myelin fibers and capillaries, and the absence of free red blood cells in the extracellular space. The obtained morphological data confirm the effectiveness of treatment of transcranial magnetic stimulation of injuries of the peripheral nervous system in relation to neurons, glial cells, myelin and non-myelin fibers of the spinal cord.

Lipomeningocele associated with diplomyelia in a dog

2018 ◽  
Vol 46 (05) ◽  
pp. 323-329 ◽  
Author(s):  
Nele Ondreka ◽  
Sara Malberg ◽  
Emma Laws ◽  
Martin Schmidt ◽  
Sabine Schulze
Keyword(s):  
Spinal Cord ◽  
Neurological Status ◽  
Split Cord Malformation ◽  
Lumbar Spinal Cord ◽  
Histopathological Diagnosis ◽  
Type I ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Subcutaneous Mass ◽  
Lumbar Spinal

SummaryA 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. The findings of the neurological examination were consistent with a lesion localization between the 3rd thoracic and 3rd lumbar spinal cord segments. Magnetic resonance imaging revealed a spina bifida with a lipomeningocele and diplomyelia (split cord malformation type I) at the level of thoracic vertebra 11 and 12 and secondary syringomyelia above the aforementioned defects in the caudal thoracic spinal cord. Surgical resection of the lipomeningocele via a hemilaminectomy was performed. After initial deterioration of the neurological status postsurgery with paraplegia and absent deep pain sensation the dog improved within 2 weeks to non-ambulatory paraparesis with voluntary urination. Six weeks postoperatively the dog was ambulatory, according to the owner. Two years after surgery the owner recorded that the dog showed a normal gait, a normal urination and no pain. Histopathological diagnosis of the biopsied material revealed a lipomeningocele which confirmed the radiological diagnosis.

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