D1R/PP2A/p-CaMKIIα signaling in the caudate putamen is involved in acute methamphetamine-induced hyperlocomotion

2021 ◽  
pp. 136102
Author(s):  
Qing Shang ◽  
Jing Xiao ◽  
Baoyao Gao ◽  
Min Liang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Caudate Putamen

scholarly journals Altered mRNA Levels of Stress-Related Peptides in Mouse Hippocampus and Caudate-Putamen in Withdrawal after Long-Term Intermittent Exposure to Tobacco Smoke or Electronic Cigarette Vapour

2021 ◽  
Vol 22 (2) ◽  
pp. 599
Author(s):  
Lucia Carboni ◽  
Luisa Ponzoni ◽  
Daniela Braida ◽  
Mariaelvina Sala ◽  
Cecilia Gotti ◽  
...  
Keyword(s):  
Public Health Problem ◽  
Mrna Levels ◽  
Obsessive Compulsive ◽  
Bdnf Mrna ◽  
Object Recognition Test ◽  
Caudate Putamen ◽  
Molecular Alterations ◽  
Marble Burying ◽  
Cigarette Withdrawal

Nicotine addiction is a severe public health problem. The aim of this study was to investigate the alterations in key neurotransmissions after 60 days of withdrawal from seven weeks of intermittent cigarette smoke, e-cigarette vapours, or an e-cigarette vehicle. In the nicotine withdrawal groups, increased depressive and anxiety/obsessive–compulsive-like behaviours were demonstrated in the tail suspension, sucrose preference and marble burying tests. Cognitive impairments were detected in the spatial object recognition test. A significant increase in Corticotropin-releasing factor (Crf) and Crf1 mRNA levels was observed, specifically after cigarette withdrawal in the caudate-putamen nucleus (CPu). The nociceptin precursor levels were reduced by cigarette (80%) and e-cigarette (50%) withdrawal in the CPu. The delta opioid receptor showed a significant reduction in the hippocampus driven by the exposure to an e-cigarette solubilisation vehicle, while the mRNA levels doubled in the CPu of mice that had been exposed to e-cigarettes. Withdrawal after exposure to e-cigarette vapour induced a 35% Bdnf mRNA decrease in the hippocampus, whereas Bdnf was augmented by 118% by cigarette withdrawal in the CPu. This study shows that long-term withdrawal-induced affective and cognitive symptoms associated to lasting molecular alterations in peptidergic signalling may determine the impaired neuroplasticity in the hippocampal and striatal circuitry.

scholarly journals Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Serena Banu Gumusoglu ◽  
Akanksha Sri Satya Chilukuri ◽  
Benjamin Wen Qing Hing ◽  
Sabrina Marie Scroggins ◽  
Sreelekha Kundu ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Ventricular Zone ◽  
Vessel Diameter ◽  
Female Offspring ◽  
Cell Number ◽  
Differentially Expressed ◽  
Adult Males ◽  
Social Approach ◽  
Caudate Putamen ◽  
Underlying Mechanisms

AbstractPreeclampsia is a severe gestational hypertensive condition linked to child neuropsychiatric disorders, although underlying mechanisms are unclear. We used a recently developed, clinically relevant animal model of preeclampsia to assess offspring. C57BL/6J mouse dams were chronically infused with arginine vasopressin (AVP) or saline (24 ng/h) throughout pregnancy. Adult offspring were behaviorally tested (Y-maze, open field, rotarod, social approach, and elevated plus maze). Offspring brain was assessed histologically and by RNA sequencing. Preeclampsia-exposed adult males exhibited increased anxiety-like behavior and social approach while adult females exhibited impaired procedural learning. Adult AVP-exposed males had reduced total neocortical volume. Adult AVP-exposed females had increased caudate–putamen volume, increased caudate–putamen cell number, and decreased excitatory synapse density in hippocampal dentate gyrus (DG), CA1, and CA3. At postnatal day 7 (P7), AVP-exposed male and female offspring both had smaller neocortex. At P7, AVP-exposed males also had smaller caudate–putamen volume, while females had increased caudate–putamen volume relative to neocortical size. Similar to P7, E18 AVP-exposed offspring had smaller dorsal forebrain, mainly in reduced intermediate, subventricular, and ventricular zone volume, particularly in males. Decreased volume was not accounted for by cell size or cerebrovascular vessel diameter changes. E18 cortical RNAseq revealed 49 differentially-expressed genes in male AVP-exposed offspring, over-representing cytoplasmic translation processes. In females, 31 genes were differentially-expressed, over-representing collagen-related and epithelial regulation pathways. Gene expression changes in E18 AVP-exposed placenta indicated potential underlying mechanisms. Deficits in behavior and forebrain development in this AVP-based preeclampsia model were distinctly different in males and females, implicating different neurobiological bases.

Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms

2020 ◽  
Vol 11 (2) ◽  
pp. 1826-1834
Author(s):  
Meiju Zhu ◽  
Hongzhu Zhu ◽  
Xiaomin Ding ◽  
Shaosheng Liu ◽  
Yuanhua Zou
Keyword(s):  
Spirulina Platensis ◽  
Treadmill Exercise ◽  
Caudate Putamen ◽  
Biochemical Indicators

This study evaluated the effects of polysaccharides from Spirulina platensis (PSP) on endurance during treadmill exercise; levels of some biochemical indicators and expressions of serotonin related genes in the caudate putamen of exercising rats.

Heightened aggression after chronic flunitrazepam in male rats: potential links to cortical and caudate–putamen-binding sites

2007 ◽  
Vol 197 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Rosa Maria M. de Almeida ◽  
Quelin Benini ◽  
Juliana S. Betat ◽  
Débora C. Hipólide ◽  
Klaus A. Miczek ◽  
...  
Keyword(s):  
Binding Sites ◽  
Male Rats ◽  
Caudate Putamen
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