Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms

2020 ◽  
Vol 11 (2) ◽  
pp. 1826-1834
Author(s):  
Meiju Zhu ◽  
Hongzhu Zhu ◽  
Xiaomin Ding ◽  
Shaosheng Liu ◽  
Yuanhua Zou
Keyword(s):  
Spirulina Platensis ◽  
Treadmill Exercise ◽  
Caudate Putamen ◽  
Biochemical Indicators

This study evaluated the effects of polysaccharides from Spirulina platensis (PSP) on endurance during treadmill exercise; levels of some biochemical indicators and expressions of serotonin related genes in the caudate putamen of exercising rats.

Immunomodulations induced in rats by exercise on a treadmill

1990 ◽  
Vol 69 (5) ◽  
pp. 1912-1915 ◽  
Author(s):  
A. Ferry ◽  
B. L. Weill ◽  
M. Rieu
Keyword(s):  
T Cell ◽  
Treadmill Exercise ◽  
Absolute Number ◽  
Not Given ◽  
Spleen Cells ◽  
Immune Parameters ◽  
Exercise Regimen ◽  
Long Duration

Various regimens of treadmill exercise (0% slope) were used with rats: 60 min at 15 m/min (T-15), 180 min at 10 m/min (T-10), and 60 min/day at 15 m/min for 6 consecutive days (T-15-6). Exercise resulted in 1) decreases in the absolute number of mononuclear spleen cells in T-10 rats, 2) significant increases in in vitro splenic T-cell blastogenesis in response to phytohemagglutinin in T-10 rats, and 3) significant decreases in T-cell blastogenesis in T-15-6 rats. T-15-6 rats were given aminoglutethimide per os before exercise sessions to study the role of corticosteroids in the alteration of splenic T-cell blastogenesis. Aminoglutethimide significantly increased the T-cell blastogenesis in these T-15-6 rats compared with those not given aminoglutethimide, whereas it had no effect on immune parameters of sedentary rats. These results show that immunomodulations in the rat depend on the treadmill exercise regimen employed. If the mechanisms of the immunomodulation induced by isolated exercise of long duration are not elucidated, these data suggest that corticosteroids are involved in the alteration in T-cell blastogenesis induced by chronic muscular exercise.

Role of the Medial and Lateral Caudate-Putamen in Mediating an Auditory Conditional Response Association

2001 ◽  
Vol 76 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Spencer Adams ◽  
Raymond P. Kesner ◽  
Michael E. Ragozzino
Keyword(s):  
Conditional Response ◽  
Caudate Putamen

scholarly journals Evaluation of the alleviative role of Chlorella vulgaris and Spirulina platensis extract against ovarian dysfunctions induced by monosodium glutamate in mice

2018 ◽  
Vol 16 (2) ◽  
pp. 653-660 ◽  
Author(s):  
Sekena H Abdel-Aziem ◽  
Heba A.M. Abd El-Kader ◽  
Faten M. Ibrahim ◽  
Hafiza A Sharaf ◽  
Aida I. El makawy
Keyword(s):  
Chlorella Vulgaris ◽  
Spirulina Platensis ◽  
Monosodium Glutamate

F.6 - ROLE OF DORSOMEDIAL CAUDATE PUTAMEN IN INTEROCEPTIVE CONDITIONING WITH THE NICOTINE STIMULUS

2013 ◽  
Vol 24 ◽  
pp. e50-e51
Author(s):  
Sergios Charntikov ◽  
Steven Pittenger ◽  
Natashia Swalve ◽  
Katherine Vestakis ◽  
Rick Bevins
Keyword(s):  
Caudate Putamen

Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor

1990 ◽  
Vol 68 (2) ◽  
pp. 561-567 ◽  
Author(s):  
K. C. Kregel ◽  
J. M. Overton ◽  
D. R. Seals ◽  
C. M. Tipton ◽  
L. A. Fisher
Keyword(s):  
Heart Rate ◽  
Vascular Resistance ◽  
Treadmill Exercise ◽  
Cardiovascular Responses ◽  
Corticotropin Releasing Factor ◽  
Receptor Blockade ◽  
Conscious Rat ◽  
The Central Nervous System ◽  
Mesenteric Vascular Resistance

The effects of intracerebroventricular (icv) administration of a corticotropin-releasing factor (CRF) receptor antagonist, alpha-helical CRF, on systemic and regional hemodynamic adjustments to exercise were studied in conscious rats. On consecutive days, rats received saline icv, alpha-helical CRF icv, and no treatment 30 min before treadmill exercise (TMX). Increases in heart rate (HR) and mean arterial pressure (MAP) in response to TMX (16.1-28.6 m/min) were similar after icv administration of saline or no treatment. In rats receiving saline icv or no treatment, estimated vascular resistance increased in the mesenteric and renal regions and declined in the iliac (hindlimb) region. After icv administration of alpha-helical CRF9-41, HR and MAP responses during TMX were significantly attenuated. In addition, TMX-induced elevations of estimated mesenteric vascular resistance and iliac blood flow velocity were blunted after CRF receptor blockade. These altered cardiovascular and hemodynamic responses were ultimately reflected in the animals' compromised ability to run. The results suggest that the central nervous system actions of endogenous CRF are necessary for the full expression of the cardiovascular adjustments to TMX in the conscious rat.

Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings

2011 ◽  
Vol 300 (6) ◽  
pp. H1983-H1989 ◽  
Author(s):  
Cinzia Perrino ◽  
Giuseppe Gargiulo ◽  
Gianluigi Pironti ◽  
Anna Franzone ◽  
Laura Scudiero ◽  
...  
Keyword(s):  
Treadmill Exercise ◽  
Cardiovascular Effects ◽  
Cardiovascular Responses ◽  
Multiple Organ ◽  
Organ Systems ◽  
Physiological Cardiac Hypertrophy ◽  
Models Of Disease ◽  
Acute Changes ◽  
Exercise In Humans

Exercise adaptations result from a coordinated response of multiple organ systems, including cardiovascular, pulmonary, endocrine-metabolic, immunologic, and skeletal muscle. Among these, the cardiovascular system is the most directly affected by exercise, and it is responsible for many of the important acute changes occurring during physical training. In recent years, the development of animal models of pathological or physiological cardiac overload has allowed researchers to precisely analyze the complex cardiovascular responses to stress in genetically altered murine models of human cardiovascular disease. The intensity-controlled treadmill exercise represents a well-characterized model of physiological cardiac hypertrophy because of its ability to mimic the typical responses to exercise in humans. In this review, we describe cardiovascular adaptations to treadmill exercise in mice and the most important parameters that can be used to quantify such modifications. Moreover, we discuss how treadmill exercise can be used to perform physiological testing in mouse models of disease and to enlighten the role of specific signaling pathways on cardiac function.

Treadmill Exercise Testing

2015 ◽  
Author(s):  
Joshua A. Turner ◽  
Todd M. Brown
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Exercise Testing ◽  
Treadmill Exercise ◽  
Prognostic Information ◽  
Performance Interpretation ◽  
Artery Disease ◽  
Treadmill Exercise Testing

Treadmill exercise testing is an important tool in the field of cardiology and is very commonly used because it is readily available, inexpensive, noninvasive, and provides pertinent diagnostic and prognostic information in assessing for the presence and severity of coronary artery disease (CAD). For decades, its primary use was to provoke and diagnose myocardial ischemia, but its clinical indications have become more numerous with time. In this chapter, we will review role of treadmill exercise testing in patients with known or suspected CAD, as well as the contraindications, complications, performance, interpretation, and its prognostics utility.

scholarly journals Potential Therapeutic Role of Dietary Supplementation with Spirulina platensis on the Erectile Function of Obese Rats Fed a Hypercaloric Diet

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Anderson Fellyp Avelino Diniz ◽  
Iara Leão Luna de Souza ◽  
Elba dos Santos Ferreira ◽  
Maria Thaynan de Lima Carvalho ◽  
Bárbara Cavalcanti Barros ◽  
...  
Keyword(s):  
Spirulina Platensis ◽  
Erectile Function ◽  
Dietary Supplementation ◽  
Diet Group ◽  
Food Supplementation ◽  
Standard Diet ◽  
Obese Rats ◽  
No Bioavailability ◽  
Hypercaloric Diet

Spirulina platensis, an important source of bioactive compounds, is a multicellular, filamentous cyanobacterium rich in high-quality proteins, vitamins, minerals, and antioxidants. Due to its nutrient composition, the alga is considered a complete food and is recognized for its anti-inflammatory, antioxidant, antiobesity, and reproprotective effects. All of which are important for prevention and treatment of organic and metabolic disorders such as obesity and erectile dysfunction. The aim of this study was to investigate the modulatory role of Spirulina platensis food supplementation and the mechanisms of action involved in reversing the damage caused by a hypercaloric diet on the erectile function of rats. The animals were divided into a standard diet group (SD, n=5); a hypercaloric diet group (HCD, n=5); a hypercaloric diet group supplemented with S. platensis at doses of 25 (HCD+SP25, n=5), 50 (HCD+SP50, n=5), and 100 mg/kg (HCD+SP100, n=5); and a hypercaloric diet group subsequently fed a standard diet (HCD+SD, n=5). In the rats fed a hypercaloric diet, dietary supplementation with S. platensis effectively increased the number of erections while decreasing latency to initiate penile erection. Additionally, S. platensis increases NO bioavailability, reduces inflammation by reducing the release of contractile prostanoids, enhances the relaxation effect promoted by acetylcholine (ACh), restores contractile reactivity damage and cavernous relaxation, reduces reactive oxygen species (ROS), and increases cavernous total antioxidant capacity (TAC). Food supplementation with S. platensis thus restores erectile function in obese rats, reduces production of contractile prostanoids, reduces oxidative stress, and increases NO bioavailability. Food supplementation with S. platensis thus emerges as a promising new therapeutic alternative for the treatment of erectile dysfunction as induced by obesity.

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