Effect of saikosaponin A on maintenance of intravenous morphine self-administration

2012 ◽  
Vol 529 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Seong Shoon Yoon ◽  
Hey Soo Kim ◽  
Hea-Young Cho ◽  
Jaesuk Yun ◽  
Eun Yong Chung ◽  
...  
Keyword(s):  
Self Administration ◽  
Intravenous Morphine ◽  
Saikosaponin A

Intravenous morphine self-administration by rats with low versus high saccharin preferences

1995 ◽  
Vol 117 (2) ◽  
pp. 248-252 ◽  
Author(s):  
B. A. Gosnell ◽  
K. E. Lane ◽  
S. M. Bell ◽  
D. D. Krahn
Keyword(s):  
Self Administration ◽  
Intravenous Morphine

scholarly journals Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats

2020 ◽  
Author(s):  
Ludovic D. Langlois ◽  
Rina Y. Berman ◽  
Ryan D. Shepard ◽  
Sarah C. Simmons ◽  
Mumeko C. Tsuda ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Sucrose Preference ◽  
Male Rats ◽  
Self Administration ◽  
Lateral Habenula ◽  
Glutamatergic Synaptic Transmission ◽  
Intravenous Morphine

AbstractEarly life stress (ELS) presents an important risk factor for drug addiction and comorbid depression and anxiety through persistent effects on the mesolimbic dopamine (DA) pathways1. Using an ELS model for child neglect (a single 24 h episode of maternal deprivation, MD) in rats, recent published works from our lab show that MD induces dysfunction in ventral tegmental area (VTA) DA neurons 2–4 and its negative controller, the lateral habenula (LHb) 5–7. In regard to LHb, MD-induced potentiation of glutamatergic synaptic transmission onto LHb neurons shifts the coordination of excitation/inhibition (E/I) balance towards excitation, resulting in an increase in the overall spontaneous neuronal activity with elevation in bursting and tonic firing, and intrinsic excitability of LHb neurons in early adolescent male rats 5–7. Here, we explored how MD affects intravenous morphine self-administration (MSA) acquisition and sucrose preference as well as glutamatergic synaptic function in LHb neurons of adult male rats self-administering morphine. We found that MD-induced increases in LHb neuronal and glutamatergic synaptic activity and E/I ratio persisted into adulthood. Moreover, MD significantly reduced morphine intake, triggered anhedonia-like behavior in the sucrose preference test (SPT), and was associated with persistent glutamatergic potentiation 24h after the last MSA session. MSA also triggered postsynaptic glutamatergic potentiation in LHb neurons of control rats during this time period. Our data highlights that ELS-induced glutamatergic plasticity in LHb may dampen the positive reinforcing properties of natural rewards and opioids, and contribute to the development of anhedonic and dysphoric states associated with opioids.

scholarly journals Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats

2020 ◽  
Vol 55 (4) ◽  
pp. 367-373
Author(s):  
Paola Maccioni ◽  
Irene Lorrai ◽  
Federica Fara ◽  
Mauro A M Carai ◽  
Gian Luigi Gessa ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
Fixed Ratio ◽  
Male Rats ◽  
Schedules Of Reinforcement ◽  
Self Administration ◽  
Structural Differences ◽  
Addictive Potential ◽  
Bupleurum Falcatum ◽  
Saikosaponin A

Abstract Aims Treatment with saikosaponin A (SSA)—an ingredient of the medicinal herb, Bupleurum falcatum—has been reported to suppress several addictive-like behaviors, including morphine, cocaine, alcohol and chocolate self-administration in male rats. The aim of this investigation was to investigate whether saikosaponins of B. falcatum other than SSA affect alcohol and chocolate self-administration in rats. Methods Ovariectomized female Sardinian alcohol-preferring (sP) and Wistar rats were trained to self-administer alcohol (15%, v/v) and a chocolate solution [5% (w/v) Nesquik® in water], respectively, under fixed ratio schedules of reinforcement. The following saikosaponins were compared to SSA: saikosaponin D (SSD; epimer of SSA), saikosaponin C (SSC), saikosaponin B2 (SSB2) and saikosaponin B4 (SSB4). All saikosaponins were tested acutely at the doses of 0, 0.25, 0.5 and 1 mg/kg (i.p.). Results Treatment with SSA and SSD resulted in highly similar, marked reductions in alcohol self-administration; SSC failed to alter lever-responding for alcohol, while SSB2 and SSB4 produced intermediate reductions. Only SSA and SSD reduced chocolate self-administration, with SSC, SSB2 and SSB4 being ineffective. Conclusions The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential.

Effects of saikosaponin A on cocaine self-administration in rats

2013 ◽  
Vol 555 ◽  
pp. 198-202 ◽  
Author(s):  
Seong Shoon Yoon ◽  
Joung-Wook Seo ◽  
Song Hee Ann ◽  
Hee Young Kim ◽  
Hey Soo Kim ◽  
...  
Keyword(s):  
Self Administration ◽  
Saikosaponin A

Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats

1977 ◽  
Vol 54 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Gilbert Carnathan ◽  
Roger E. Meyer ◽  
Joseph Cochin
Keyword(s):  
Self Administration ◽  
Intravenous Morphine ◽  
Narcotic Blockade

Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

1988 ◽  
Vol 30 (4) ◽  
pp. 1051-1057 ◽  
Author(s):  
Steven I. Dworkin ◽  
Glenn F. Guerin ◽  
Conchita Co ◽  
Nick E. Goeders ◽  
James E. Smith
Keyword(s):  
Nucleus Accumbens ◽  
Self Administration ◽  
Intravenous Morphine ◽  
6 Hydroxydopamine
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