Narcotic blockade, length of addiction, and persistence of intravenous morphine self-administration in rats

1977 ◽  
Vol 54 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Gilbert Carnathan ◽  
Roger E. Meyer ◽  
Joseph Cochin
Keyword(s):  
Self Administration ◽  
Intravenous Morphine ◽  
Narcotic Blockade

Intravenous morphine self-administration by rats with low versus high saccharin preferences

1995 ◽  
Vol 117 (2) ◽  
pp. 248-252 ◽  
Author(s):  
B. A. Gosnell ◽  
K. E. Lane ◽  
S. M. Bell ◽  
D. D. Krahn
Keyword(s):  
Self Administration ◽  
Intravenous Morphine

scholarly journals Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats

2020 ◽  
Author(s):  
Ludovic D. Langlois ◽  
Rina Y. Berman ◽  
Ryan D. Shepard ◽  
Sarah C. Simmons ◽  
Mumeko C. Tsuda ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Sucrose Preference ◽  
Male Rats ◽  
Self Administration ◽  
Lateral Habenula ◽  
Glutamatergic Synaptic Transmission ◽  
Intravenous Morphine

AbstractEarly life stress (ELS) presents an important risk factor for drug addiction and comorbid depression and anxiety through persistent effects on the mesolimbic dopamine (DA) pathways1. Using an ELS model for child neglect (a single 24 h episode of maternal deprivation, MD) in rats, recent published works from our lab show that MD induces dysfunction in ventral tegmental area (VTA) DA neurons 2–4 and its negative controller, the lateral habenula (LHb) 5–7. In regard to LHb, MD-induced potentiation of glutamatergic synaptic transmission onto LHb neurons shifts the coordination of excitation/inhibition (E/I) balance towards excitation, resulting in an increase in the overall spontaneous neuronal activity with elevation in bursting and tonic firing, and intrinsic excitability of LHb neurons in early adolescent male rats 5–7. Here, we explored how MD affects intravenous morphine self-administration (MSA) acquisition and sucrose preference as well as glutamatergic synaptic function in LHb neurons of adult male rats self-administering morphine. We found that MD-induced increases in LHb neuronal and glutamatergic synaptic activity and E/I ratio persisted into adulthood. Moreover, MD significantly reduced morphine intake, triggered anhedonia-like behavior in the sucrose preference test (SPT), and was associated with persistent glutamatergic potentiation 24h after the last MSA session. MSA also triggered postsynaptic glutamatergic potentiation in LHb neurons of control rats during this time period. Our data highlights that ELS-induced glutamatergic plasticity in LHb may dampen the positive reinforcing properties of natural rewards and opioids, and contribute to the development of anhedonic and dysphoric states associated with opioids.

Effect of saikosaponin A on maintenance of intravenous morphine self-administration

2012 ◽  
Vol 529 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Seong Shoon Yoon ◽  
Hey Soo Kim ◽  
Hea-Young Cho ◽  
Jaesuk Yun ◽  
Eun Yong Chung ◽  
...  
Keyword(s):  
Self Administration ◽  
Intravenous Morphine ◽  
Saikosaponin A

Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

1988 ◽  
Vol 30 (4) ◽  
pp. 1051-1057 ◽  
Author(s):  
Steven I. Dworkin ◽  
Glenn F. Guerin ◽  
Conchita Co ◽  
Nick E. Goeders ◽  
James E. Smith
Keyword(s):  
Nucleus Accumbens ◽  
Self Administration ◽  
Intravenous Morphine ◽  
6 Hydroxydopamine

Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats

2009 ◽  
Vol 92 (4) ◽  
pp. 676-682 ◽  
Author(s):  
Rui-Bin Su ◽  
Wei-Ping Wang ◽  
Xin-Qiang Lu ◽  
Ning Wu ◽  
Zhi-min Liu ◽  
...  
Keyword(s):  
Self Administration ◽  
Intravenous Morphine

scholarly journals Effects of tolerance on intravenous morphine self-administration behavior

1976 ◽  
Vol 4 (1) ◽  
pp. 97-98 ◽  
Author(s):  
Stanley G. Smith ◽  
Toreen E. Werner ◽  
W. Marvin Davis
Keyword(s):  
Self Administration ◽  
Intravenous Morphine

scholarly journals Increased intravenous morphine self-administration following Roux-en-Y gastric bypass in dietary obese rats

2016 ◽  
Vol 123 ◽  
pp. 47-52 ◽  
Author(s):  
Jessica M. Biegler ◽  
Christopher S. Freet ◽  
Nelli Horvath ◽  
Ann M. Rogers ◽  
Andras Hajnal
Keyword(s):  
Gastric Bypass ◽  
Self Administration ◽  
Obese Rats ◽  
Intravenous Morphine
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