Thiol redox state (TRS) and oxidative stress in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure

2004 ◽  
Vol 357 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
George Zervoudakis ◽  
Nikolaos T Panagopoulos ◽  
Christos D Georgiou ◽  
Fevronia Angelatou ◽  
...  
2005 ◽  
Vol 376 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Ioannis Papapostolou ◽  
George Zervoudakis ◽  
Christos D. Georgiou ◽  
Nikolaos A. Matsokis ◽  
...  

2008 ◽  
Vol 54 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Christos D. Georgiou

Sclerotial differentiation in Sclerotinia minor is associated with oxidative stress and thiol redox state. The significance of oxidative stress to sclerotial differentiation was revealed by the higher oxidative stress of S. minor compared with a nonsclerotiogenic counterpart. The effect of thiol redox state on sclerotial differentiation was shown by the antioxidant action of the thiol (-SH) group of N-acetylcysteine and cysteine and by an unknown (not antioxidant) role of glutathione (GSH) on S. minor. The nonantioxidant role of GSH was indicated by the differentiation-inhibiting and differentiation-noninhibiting actions of the GSH biosynthesis inhibitor l-buthionine-S,R-sulfoximine and the GSH biosynthesis inducer l-2-oxo-thiazolidine-4-carboxylate, respectively, and by the increase of oxidative stress they caused during the transition from the undifferentiated to differentiated state of S. minor. Moreover, N-acetylcysteine can be used as a potent nontoxic fungicide against this phytopathogenic fungus by acting as a growth-inhibiting cytotoxic oxidant and by sustaining the fungus in the undifferentiated hyphal stage, which is vulnerable to degradation by soil microorganisms.


2004 ◽  
Vol 62 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
George Zervoudakis ◽  
Christos D. Georgiou ◽  
Fevronia Angelatou ◽  
Nikolaos A. Matsokis ◽  
...  

Epilepsia ◽  
2005 ◽  
Vol 46 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
George Zervoudakis ◽  
Christos D. Georgiou ◽  
Fevronia Angelatou ◽  
Nikolaos A. Matsokis ◽  
...  

2008 ◽  
Vol 38 (9) ◽  
pp. 2419-2425 ◽  
Author(s):  
Patrizia Castellani ◽  
Giovanna Angelini ◽  
Laura Delfino ◽  
Andrea Matucci ◽  
Anna Rubartelli

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