scholarly journals The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

2017 ◽  
Vol 102 ◽  
pp. 105-113 ◽  
Author(s):  
Anne Cathrine Nøhr ◽  
Mohamed A. Shehata ◽  
Alexander S. Hauser ◽  
Vignir Isberg ◽  
Jacek Mokrosinski ◽  
...  
Keyword(s):  
G Protein ◽  
Adrenocorticotropic Hormone ◽  
G Protein Coupled Receptor ◽  
Core Motif ◽  
Melanocyte Stimulating Hormone ◽  
Conserved Core ◽  
G Protein Coupled ◽  
Stimulating Hormone

scholarly journals Binding of α-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway

1998 ◽  
Vol 331 (1) ◽  
pp. 211-216 ◽  
Author(s):  
Joseph J. BUGGY
Keyword(s):  
G Protein ◽  
Protein Tyrosine Kinase ◽  
Cellular Proliferation ◽  
B Lymphocyte ◽  
Janus Kinase ◽  
Lymphocyte Function ◽  
Amino Acid Peptide ◽  
Melanocyte Stimulating Hormone ◽  
G Protein Coupled ◽  
Stimulating Hormone

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino-acid peptide with a variety of physiological effects, including the stimulation of melanocyte proliferation and melanogenesis, temperature control, control of prolactin release and the modulation of cytokine action in the immune system. There are five known subtypes of G-protein-coupled receptors, which bind with different affinities to α-MSH. This paper provides evidence that Ba/F3 pro-B-lymphocyte cells express the gene for the melanocortin 5 (MC5) receptor and specifically bind α-MSH. Western-blot analysis reveals that α-MSH binding stimulates Janus kinase 2 (JAK2) and signal transducers and activators of transcription (STAT1) tyrosine phosphorylation in both Ba/F3 cells and human cultured IM-9 lymphocytes. α-MSH is further revealed to activate JAK2 in mouse L-cells stably expressing the human MC5 receptor. Finally, α-MSH binding is shown to result in an enhancement of cellular proliferation. These findings identify a new protein tyrosine kinase pathway in the action of α-MSH, and suggest that α-MSH plays an important role in B-lymphocyte function via the activation of the same intracellular phosphorylation pathway used by cytokines and growth factors.

Kinase-Inactive G-Protein-Coupled Receptor Kinases Are Able to Attenuate Follicle-Stimulating Hormone-Induced Signaling

2001 ◽  
Vol 282 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Eric Reiter ◽  
Sébastien Marion ◽  
Fabienne Robert ◽  
Carine Troispoux ◽  
François Boulay ◽  
...  
Keyword(s):  
G Protein ◽  
Follicle Stimulating Hormone ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled ◽  
Stimulating Hormone

scholarly journals Involvement of G Protein-Coupled Receptor Kinases and Arrestins in Desensitization to Follicle-Stimulating Hormone Action

1999 ◽  
Vol 13 (9) ◽  
pp. 1599-1614 ◽  
Author(s):  
Carine Troispoux ◽  
Florian Guillou ◽  
Jean-Marc Elalouf ◽  
Dmitri Firsov ◽  
Luisa Iacovelli ◽  
...  
Keyword(s):  
G Protein ◽  
Follicle Stimulating Hormone ◽  
Hormone Action ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled ◽  
Stimulating Hormone

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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