Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase

2016 ◽  
Vol 101 ◽  
pp. 144-155 ◽  
Author(s):  
Fang Fang Zhang ◽  
Norimitsu Morioka ◽  
Hiromi Abe ◽  
Shiori Fujii ◽  
Kazuki Miyauchi ◽  
...  
Keyword(s):  
Map Kinase ◽  
Dorsal Horn ◽  
Adrenergic Receptor ◽  
Spinal Dorsal Horn ◽  
P38 Map Kinase ◽  
Mechanical Hypersensitivity ◽  
Spinal Dorsal ◽  
Β2 Adrenergic Receptor ◽  
Stimulation Of

Electrical stimulation of the primary somatosensory cortex inhibits spinal dorsal horn neuron activity

2005 ◽  
Vol 1057 (1-2) ◽  
pp. 134-140 ◽  
Author(s):  
Arun K. Senapati ◽  
Paula J. Huntington ◽  
Stacey C. LaGraize ◽  
Hilary D. Wilson ◽  
Perry N. Fuchs ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Somatosensory Cortex ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Neuron Activity ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neuron ◽  
Horn Neuron ◽  
Stimulation Of

Interactions of opiate and adrenergic receptor subtypes in the spinal dorsal horn

Pain ◽  
1990 ◽  
Vol 41 ◽  
pp. S195
Author(s):  
K. Omote ◽  
L.M. Kitahata ◽  
J.G. Collins ◽  
K. Nakatani
Keyword(s):  
Dorsal Horn ◽  
Adrenergic Receptor ◽  
Spinal Dorsal Horn ◽  
Receptor Subtypes ◽  
Spinal Dorsal

Increased Nociceptive Input Rapidly Modulates Spinal GABAergic Transmission Through Endogenously Released Glutamate

2007 ◽  
Vol 97 (1) ◽  
pp. 871-882 ◽  
Author(s):  
Hong-Yi Zhou ◽  
Hong-Mei Zhang ◽  
Shao-Rui Chen ◽  
Hui-Lin Pan
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Primary Afferents ◽  
Group Iii ◽  
Metabotropic Glutamate ◽  
Spinal Dorsal ◽  
Glutamate Receptor Antagonists ◽  
Nociceptive Input ◽  
Stimulation Of

Stimulation of nociceptive primary afferents elicits pain by promoting glutamatergic transmission in the spinal cord. Little is known about how increased nociceptive input controls GABAergic tone in the spinal dorsal horn. In this study, we determined how increased nociceptive inflow affects GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) of lamina II neurons by using whole cell recordings in rat spinal cord slices. Bath application of capsaicin for 3 min induced a long-lasting inhibition of sIPSCs in 50% of the neurons tested. In the other half of the neurons, capsaicin either increased the frequency of sIPSCs (34.6%) or had no effect on sIPSCs (15.4%). The GABAA current elicited by puff application of GABA was not altered by capsaicin. Capsaicin did not inhibit sIPSCs in rats treated with intrathecal pertussis toxin. Also, capsaicin failed to inhibit sIPSCs in the presence of ionotropic glutamate receptor antagonists or in the presence of both LY341495 and CPPG (group II and group III metabotropic glutamate receptor antagonists, respectively). However, when LY341495 or CPPG was used alone, capsaicin still decreased the frequency of sIPSCs in some neurons. Additionally, bradykinin significantly inhibited sIPSCs in a population of lamina II neurons and this inhibitory effect was also abolished by LY341495 and CPPG. Our study provides novel information that stimulation of nociceptive primary afferents rapidly suppresses GABAergic input to many dorsal horn neurons through endogenous glutamate and activation of presynaptic group II and group III metabotropic glutamate receptors. These findings extend our understanding of the microcircuitry of the spinal dorsal horn involved in nociception.

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