Effect of electrical stimulation of sciatic nerve on synaptic plasticity of spinal dorsal horn and spinal c-fos expression in neonatal, juvenile and adult rats

2012 ◽  
Vol 1448 ◽  
pp. 11-19 ◽  
Author(s):  
Jiang Wu ◽  
Qisheng Hu ◽  
Deying Huang ◽  
Xueling Chen ◽  
Jie Chen
Keyword(s):  
Electrical Stimulation ◽  
Synaptic Plasticity ◽  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Adult Rats ◽  
Spinal Dorsal ◽  
Fos Expression ◽  
Stimulation Of

Electrical stimulation of the primary somatosensory cortex inhibits spinal dorsal horn neuron activity

2005 ◽  
Vol 1057 (1-2) ◽  
pp. 134-140 ◽  
Author(s):  
Arun K. Senapati ◽  
Paula J. Huntington ◽  
Stacey C. LaGraize ◽  
Hilary D. Wilson ◽  
Perry N. Fuchs ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Somatosensory Cortex ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Neuron Activity ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neuron ◽  
Horn Neuron ◽  
Stimulation Of

Inhibition of spinal cord dorsal horn neuronal activity by electrical stimulation of the cerebellar cortex

2011 ◽  
Vol 106 (5) ◽  
pp. 2515-2522 ◽  
Author(s):  
Christopher E. Hagains ◽  
Arun K. Senapati ◽  
Paula J. Huntington ◽  
Ji-Wei He ◽  
Yuan B. Peng
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Dorsal Horn ◽  
Cerebellar Cortex ◽  
Spinal Dorsal Horn ◽  
Dynamic Range ◽  
Spinal Cord Dorsal Horn ◽  
Spinal Dorsal ◽  
Spinal Cord Dorsal ◽  
Stimulation Of

The cerebellum plays a major role in not only modulating motor activity, but also contributing to other functions, including nociception. The intermediate hemisphere of the cerebellum receives sensory input from the limbs. With the extensive connection between the cerebellum to brain-stem structures and cerebral cortex, it is possible that the cerebellum may facilitate the descending system to modulate spinal dorsal horn activity. This study provided the first evidence to support this hypothesis. Thirty-one wide-dynamic-range neurons from the left lumbar and 27 from the right lumbar spinal dorsal horn were recorded in response to graded mechanical stimulation (brush, pressure, and pinch) at the hind paws. Electrical stimulation of the cerebellar cortex of the left intermediate hemisphere significantly reduced spinal cord dorsal horn neuron-evoked responses bilaterally in response to peripheral high-intensity mechanical stimuli. It is concluded that the cerebellum may play a potential antinociceptive role, probably through activating descending inhibitory pathways indirectly.

Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons

Pain ◽  
2019 ◽  
Vol 160 (5) ◽  
pp. 1082-1092 ◽  
Author(s):  
Zongqin Zhang ◽  
Xiaobao Ding ◽  
Zhiwei Zhou ◽  
Zhuang Qiu ◽  
Naihao Shi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Synaptic Plasticity ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Sirtuin 1 ◽  
Diabetic Neuropathic Pain ◽  
Dorsal Horn Neurons ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neurons

scholarly journals Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Cell Reports ◽  
2019 ◽  
Vol 27 (13) ◽  
pp. 3844-3859.e6 ◽  
Author(s):  
Li-Jun Zhou ◽  
Jiyun Peng ◽  
Ya-Nan Xu ◽  
Wei-Jie Zeng ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Synaptic Plasticity ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal
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