Effect of early decrease in the lesion size on late brain tissue loss, synaptophysin expression and functionality after a focal brain lesion in rats

2007 ◽  
Vol 50 (2) ◽  
pp. 328-335 ◽  
Author(s):  
E. Millerot-Serrurot ◽  
A. Chausset ◽  
C. Mossiat ◽  
A. Prigent-Tessier ◽  
N. Bertrand ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Brain Lesion ◽  
Lesion Size ◽  
Tissue Loss ◽  
Focal Brain Lesion

Reorganisation of the sensorimotor cortex after early focal brain lesion: a functional MRI study in monozygotic twins

Neuroreport ◽  
2001 ◽  
Vol 12 (7) ◽  
pp. 1335-1340 ◽  
Author(s):  
Giovanni Cioni ◽  
Domenico Montanaro ◽  
Michela Tosetti ◽  
Raffaello Canapicchi ◽  
Brunello Ghelarducci
Keyword(s):  
Functional Mri ◽  
Sensorimotor Cortex ◽  
Brain Lesion ◽  
Monozygotic Twins ◽  
Focal Brain Lesion ◽  
Mri Study

Progressive brain tissue loss in schizophrenia

2016 ◽  
Vol 173 (3) ◽  
pp. 121-123 ◽  
Author(s):  
Neeltje E.M. van Haren ◽  
René S. Kahn
Keyword(s):  
Brain Tissue ◽  
Tissue Loss

Abstract T P234: Multiparametric Assessment of Longitudinal Changes in Tissue Microstructure in Normal and Abnormal Brain Tissue in Patients with Small Vessel Disease

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Maria D Valdes-Hernandez ◽  
Paul A Armitage ◽  
Eleni Sakka ◽  
Susana Munoz Maniega ◽  
Natalie A Royle ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Tissue ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Mean Diffusivity ◽  
Tissue Loss ◽  
Minor Stroke ◽  
Normal Brain ◽  
Limited Information ◽  
Time Points

Background: Volume measures of normal brain tissue and white matter hyperintensities (WMH) between two time points gives limited information about the complex dynamics of tissue change. We evaluated two quantitative parameters that characterise the microstructure of normal-appearing white matter (NAWM), deep grey matter (DGM) and WMH on brain images obtained at presentation with minor stroke and at 1 year to investigate the microstructural changes. Methods: From 182 brain MRI datasets of patients with minor stroke obtained at baseline and 1 year, we extracted the WMH, DGM and NAWM, and separated WMH into less-intense and intense WMH, using validated semi-automatic methods and validated criteria. We registered the binary structural masks to diffusion space and performed a voxel-wise subtraction of the combined masks at both time points. Then we measured fractional anisotropy (FA) and mean diffusivity (MD)(valuex10 -9 m 2 /s) in each tissue mask at baseline and 1 year. Results: WMH volume median increase was 1.4ml (IQR 6.98) mainly due to changes in less-intense WMH: 0.94ml (7.13). WMH that were visible at both time points, ie damage that remained after a year, had the lowest FA= 0.21(0.06) and highest MD=1.05(0.12) at baseline, and were mainly intense WMH at baseline (FA=0.12(0.03), MD=1.55(0.27)). WMH seen only at follow-up, ie that were NAWM at baseline, had the highest FA=0.30(0.06) and lowest MD=0.85 (0.06) at baseline. WMH that were observed only at baseline had intermediate FA=0.26(0.08) and MD=0.90(0.10). NAWM FA=0.26(0.03), MD=0.78(0.04) and DGM FA=0.23(0.03), MD=0.79(0.06) did not change between time points. Conclusions: WMH at baseline can partially evolve to normal-appearing tissues, remain or precede tissue loss. Differentiation between severe and subtle damage and spatial analysis are necessary to characterise the dynamic of WMH evolution.

scholarly journals Complex treatment at AIDS-associated focal brain lesion

2011 ◽  
Vol 0 (1) ◽  
pp. 15-22
Author(s):  
Lyudmila Dzyak ◽  
Mykola Zorin ◽  
Andriy Sirko ◽  
Ihor Kirpa ◽  
N. Okunevych ◽  
...  
Keyword(s):  
Brain Lesion ◽  
Complex Treatment ◽  
Focal Brain Lesion

scholarly journals Neuroanatomic correlates of visual hallucinations in poststroke hemianopic patients

Neurology ◽  
2020 ◽  
Vol 94 (18) ◽  
pp. e1885-e1891
Author(s):  
Fiora Martinelli ◽  
Céline Perez ◽  
Florent Caetta ◽  
Michaël Obadia ◽  
Julien Savatovsky ◽  
...  
Keyword(s):  
Visual Recognition ◽  
Striate Cortex ◽  
Clinical Care ◽  
Brain Lesion ◽  
Inverse Correlation ◽  
Occipital Lobe ◽  
Lesion Size ◽  
Homonymous Hemianopia ◽  
Small Lesion ◽  
Visual Hallucinations

ObjectivesHomonymous hemianopia (HH) is the most frequent visual-field defect after a stroke. Some of these patients also have visual hallucinations, the origin and frequency of which remain largely unknown. The aims of this work were to determine the occurrence of visual hallucinations among poststroke hemianopic patients in function of the location (Brodmann areas) of the brain lesion, as determined by MRI, and to study the neuroanatomic correlates of these hallucinations by nature, frequency, and type.MethodsOne hundred sixteen patients with HH who had had a stroke in the posterior region, including the occipital lobe, participated in the study. We evaluated the frequency and nature of visual hallucinations with the Questionnaire for Hallucinations in Homonymous Hemianopia. The volume of each patient's brain lesion was modeled in 3 dimensions.ResultsOf 116 patients with an HH from a cortical infarction, 85 were excluded due to confounding factors associated with hallucinations. In the final cohort of 31 patients matched for lesion location and etiology, 58% had experienced hallucinations. A significant inverse correlation between lesion size and the frequency of visual hallucinations emerged. The presence of visual hallucinations in poststroke hemianopic patients requires a relatively small lesion that includes, at the very least, loss of the striate cortex but that spares Brodmann area 19, 20, and 37.ConclusionOur results suggest that visual hallucinations might be due to complex interactions between damaged areas and intact areas of the visual cortex. We discuss these findings regarding models of perception and of visual recognition. Our results also have implications for the clinical care of patients with HH who have had a stroke.

scholarly journals The relationship of brain-tissue loss volume and lesion location to cognitive deficit

1986 ◽  
Vol 6 (2) ◽  
pp. 301-307 ◽  
Author(s):  
J Grafman ◽  
A Salazar ◽  
H Weingartner ◽  
S Vance ◽  
D Amin
Keyword(s):  
Brain Tissue ◽  
Cognitive Deficit ◽  
Tissue Loss ◽  
Lesion Location ◽  
Relationship Of ◽  
The Relationship

Pattern of brain tissue loss associated with freezing of gait in Parkinson disease

Neurology ◽  
2012 ◽  
Vol 78 (6) ◽  
pp. 409-416 ◽  
Author(s):  
V. S. Kostic ◽  
F. Agosta ◽  
M. Pievani ◽  
E. Stefanova ◽  
M. Jecmenica-Lukic ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Brain Tissue ◽  
Freezing Of Gait ◽  
Tissue Loss

Effects of brain-lesion size and location on temporal-order judgment

Neuroreport ◽  
2004 ◽  
Vol 15 (15) ◽  
pp. 2401-2405 ◽  
Author(s):  
Marc Wittmann ◽  
Ariane Burtscher ◽  
Wolfgang Fries ◽  
Nicole von Steinbüchel
Keyword(s):  
Temporal Order ◽  
Temporal Order Judgment ◽  
Brain Lesion ◽  
Lesion Size
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