Impact of portal branch ligation on tissue regeneration, microcirculatory response and microarchitecture in portal blood-deprived and undeprived liver tissue

2011 ◽  
Vol 81 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Michael Gock ◽  
Christian Eipel ◽  
Michael Linnebacher ◽  
Ernst Klar ◽  
Brigitte Vollmar
Keyword(s):  
Tissue Regeneration ◽  
Liver Tissue ◽  
Portal Blood ◽  
Portal Branch ◽  
Portal Branch Ligation

Sustained function in atrophying liver tissue after portal branch ligation in the rat

2003 ◽  
Vol 114 (2) ◽  
pp. 146-155 ◽  
Author(s):  
Lars Mueller ◽  
Rainer Grotelueschen ◽  
Jannine Meyer ◽  
Yogesh K Vashist ◽  
Awad Abdulgawad ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Portal Branch ◽  
Portal Branch Ligation

scholarly journals Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 756-760 ◽  
Author(s):  
Toshimi Kaido ◽  
Akira Yoshikawa ◽  
Shin-ichi Seto ◽  
Shoji Yamaoka ◽  
Maki Sato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Portal Branch ◽  
Extensive Hepatectomy ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

Portal branch ligation induces efficient retrovirus-mediated gene delivery in rat liver

2004 ◽  
Vol 6 (5) ◽  
pp. 507-513 ◽  
Author(s):  
Isabelle Lorand ◽  
Corinne Vons ◽  
Tuan Nguyen ◽  
Virginie Di Rico ◽  
Aurore Coulomb ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Rat Liver ◽  
Portal Branch ◽  
Portal Branch Ligation

scholarly journals Molecular mechanisms of apoptosis in the liver of rats after portal branch ligation with and without retrorsine

2004 ◽  
Vol 84 (5) ◽  
pp. 618-628 ◽  
Author(s):  
Christian Picard ◽  
Peter Starkel ◽  
Christine Sempoux ◽  
Alain Saliez ◽  
Valérie Lebrun ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Portal Branch ◽  
Portal Branch Ligation

Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipotent hepatic progenitor cells

2010 ◽  
Vol 403 (3-4) ◽  
pp. 298-304 ◽  
Author(s):  
Hiroshi Sakai ◽  
Yoh-ichi Tagawa ◽  
Miho Tamai ◽  
Hiroaki Motoyama ◽  
Shinichiro Ogawa ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Hepatic Progenitor Cells ◽  
Portal Branch ◽  
Isolation And Characterization ◽  
Portal Branch Ligation

Hepatic Blood Flow in Rats with Portal Branch Ligation

1985 ◽  
Vol 17 (3) ◽  
pp. 150-154 ◽  
Author(s):  
Nicole More ◽  
B. Basse-Cathalinat ◽  
Paulette Bioulac-Sage ◽  
Christiane Bedin ◽  
C. Balabaud
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Portal Branch ◽  
Portal Branch Ligation

Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue

2007 ◽  
Vol 292 (6) ◽  
pp. G1534-G1542 ◽  
Author(s):  
Otto Kollmar ◽  
Marcus Corsten ◽  
Claudia Scheuer ◽  
Brigitte Vollmar ◽  
Martin K. Schilling ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Blood Flow ◽  
Tissue Oxygenation ◽  
Portal Branch ◽  
Hepatic Microcirculation ◽  
Doppler Flowmetry ◽  
Liver Atrophy ◽  
Microvascular Remodeling ◽  
Perfusion Failure ◽  
Portal Branch Ligation

Portal branch ligation (PBL) may prevent liver failure after extended hepatic resection. However, clinical studies indicate that tumors within the ligated lobe develop accelerated growth. Although it is well known that tumor growth depends on the host's microvascularization, there is no information about how PBL affects the hepatic microcirculation. Our aims were to determine hepatic artery response, liver microcirculation, tissue oxygenation, and cell proliferation after PBL. Therefore, we used intravital multifluorescence microscopy, laser-Doppler flowmetry, immunohistochemistry, and biochemical techniques to examine microcirculatory responses, microvascular remodeling, and cellular consequences after left lateral PBL in BALB/c mice. During the first 7 days, PBL induced a reduction of left hilar blood flow by ∼50%. This resulted in 80% sinusoidal perfusion failure, significant parenchymal hypoxia, and liver atrophy. After 14 days, however, left hilar blood flow was found to be restored. However, remodeling of the microvasculature included a rarefaction of the sinusoidal network, however, without substantial perfusion failure, compensated by a hepatic arterial buffer response and significant sinusoidal dilatation. This resulted in normalization of tissue oxygenation, indicating arterialization of the ligated lobe. Interestingly, late microvascular remodeling was associated with increased endothelial nitric oxide synthase expression, significant hepatocellular proliferation, and weight gain of the ligated lobe. Thus PBL induces only an initial microcirculatory failure with liver atrophy, followed by a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and hepatocellular proliferation. This may explain the accelerated tumor progression occasionally observed in patients after PBL.

Sign in / Sign up

Export Citation Format

Share Document