Hepatic Blood Flow in Rats with Portal Branch Ligation

1985 ◽  
Vol 17 (3) ◽  
pp. 150-154 ◽  
Author(s):  
Nicole More ◽  
B. Basse-Cathalinat ◽  
Paulette Bioulac-Sage ◽  
Christiane Bedin ◽  
C. Balabaud
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Portal Branch ◽  
Portal Branch Ligation

Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue

2007 ◽  
Vol 292 (6) ◽  
pp. G1534-G1542 ◽  
Author(s):  
Otto Kollmar ◽  
Marcus Corsten ◽  
Claudia Scheuer ◽  
Brigitte Vollmar ◽  
Martin K. Schilling ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Blood Flow ◽  
Tissue Oxygenation ◽  
Portal Branch ◽  
Hepatic Microcirculation ◽  
Doppler Flowmetry ◽  
Liver Atrophy ◽  
Microvascular Remodeling ◽  
Perfusion Failure ◽  
Portal Branch Ligation

Portal branch ligation (PBL) may prevent liver failure after extended hepatic resection. However, clinical studies indicate that tumors within the ligated lobe develop accelerated growth. Although it is well known that tumor growth depends on the host's microvascularization, there is no information about how PBL affects the hepatic microcirculation. Our aims were to determine hepatic artery response, liver microcirculation, tissue oxygenation, and cell proliferation after PBL. Therefore, we used intravital multifluorescence microscopy, laser-Doppler flowmetry, immunohistochemistry, and biochemical techniques to examine microcirculatory responses, microvascular remodeling, and cellular consequences after left lateral PBL in BALB/c mice. During the first 7 days, PBL induced a reduction of left hilar blood flow by ∼50%. This resulted in 80% sinusoidal perfusion failure, significant parenchymal hypoxia, and liver atrophy. After 14 days, however, left hilar blood flow was found to be restored. However, remodeling of the microvasculature included a rarefaction of the sinusoidal network, however, without substantial perfusion failure, compensated by a hepatic arterial buffer response and significant sinusoidal dilatation. This resulted in normalization of tissue oxygenation, indicating arterialization of the ligated lobe. Interestingly, late microvascular remodeling was associated with increased endothelial nitric oxide synthase expression, significant hepatocellular proliferation, and weight gain of the ligated lobe. Thus PBL induces only an initial microcirculatory failure with liver atrophy, followed by a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and hepatocellular proliferation. This may explain the accelerated tumor progression occasionally observed in patients after PBL.

Hepatic Blood Flow in Patients with Tumors of the Liver

1963 ◽  
Vol 44 (6) ◽  
pp. 733-739 ◽  
Author(s):  
Kathleen M. Wartnaby ◽  
I.A.D. Bouchier ◽  
C.E. Pope ◽  
Sheila Sherlock
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Tumors Of The Liver

External Recording Method for Estimating Hepatic Blood Flow With the Use of Radiogold

1959 ◽  
Vol 36 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Joseph S. Burkle ◽  
Marvin L. Gliedman
Keyword(s):  
Blood Flow ◽  
Hepatic Blood Flow ◽  
Recording Method

The Clearance of 133Xenon from the Liver Intraportal Injection in Man

1965 ◽  
Vol 05 (03) ◽  
pp. 241-245 ◽  
Author(s):  
K.-F. Aronsen ◽  
B. Ericsson ◽  
A. Fajgelj ◽  
S.-E. Lindell
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Hepatic Blood Flow ◽  
Scintillation Detectors ◽  
Disappearance Rate ◽  
Simultaneous Measurements

Summary 133Xe dissolved in saline was injected into the portal vein in man. Hepatic blood flow was calculated from the disappearance rate of 133Xe recorded with scintillation detectors placed over the liver. The results are discussed and related to simultaneous measurements of the pressure in the portal vein.

Hepatic Blood Flow with Colloidal 198Au in the Diagnosis of Chronic Hepatitis in Children

1975 ◽  
Vol 14 (02) ◽  
pp. 158-162
Author(s):  
Viorica Szantay ◽  
Lidia Marian
Keyword(s):  
Blood Flow ◽  
Chronic Hepatitis ◽  
Hepatic Blood Flow ◽  
Hepatitis A ◽  
Clinical Findings ◽  
Active Chronic Hepatitis ◽  
Normal Children ◽  
Function Tests ◽  
Biochemical Function ◽  
Diagnostic Criterion

SummaryTracer quantities of colloidal 198Au were used to estimate the hepatic blood flow in normal children and in children with active or progressive chronic hepatitis and also to obtain scintigrams of the liver.In active chronic hepatitis a significant decrease in HBF values was observed, suggesting that the method may be used as a diagnostic criterion which is superior to hepatic scintigraphy.In progressive chronic hepatitis HBF values even lower than those in active hepatitis were observed. Together with more characteristic clinical findings and abnormal results of biochemical function tests, they underline the value of the method in estimating the severity and the evolution of the disease.

Clinical Application of Radiofrequency Ablation for Malignant Liver Tumor during Interruption of Hepatic Blood Flow

2000 ◽  
Vol 18 ◽  
pp. 121-125
Author(s):  
Takashi Shibata ◽  
Takahiro Niinobu ◽  
Masashi Kitada ◽  
Takashi Shimano ◽  
Motohisa Takami ◽  
...  
Keyword(s):  
Blood Flow ◽  
Radiofrequency Ablation ◽  
Clinical Application ◽  
Hepatic Blood Flow ◽  
Liver Tumor ◽  
Malignant Liver Tumor ◽  
Malignant Liver

scholarly journals Changes in Hepatic Hemodynamics due to Primary Liver Tumours

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 245-248 ◽  
Author(s):  
F. Jakab ◽  
Z. Ráth ◽  
F. Schmal ◽  
P. Nagy ◽  
J. Faller
Keyword(s):  
Hepatocellular Carcinoma ◽  
Blood Flow ◽  
Hepatic Artery ◽  
Hepatic Blood Flow ◽  
Primary Hepatocellular Carcinoma ◽  
Portal Venous Flow ◽  
Venous Flow ◽  
Control Value ◽  
Early Results ◽  
Total Hepatic Blood Flow

Data regarding the afferent circulation of the liver in patients with primary hepatocellular carcinoma are controversial, we have carried out measurement of hepatic arterial and portal venous flow intraoperatively by transit time ultrasonic volume flowmetry. In patients with primary hepatocellular carcinoma the hepatic artery flow increased to 0.55±0.211 compared with the control value of 0.37±0.102 1/min. (p<0.01). The portal venous flow decreased from 0.61±0.212 l/min, to 0.47±l/min. p<0.01). Due to the opposite changes in the afferent circulation the total hepatic blood flow did not change significantly, compared with controls.The ratio of hepatic arterial flow to portal vein flow increased to 1.239±0.246 in patients with hepatocellular carcinoma, which is double of the control value (0.66±0.259 l/min). After resection this ratio did not change.The resection did not alter hepatic artery or portal venous flow significantly, although the total hepatic blood flow decreased significantly (p<0.01).On the basis of our early results it is possible that the ratio of the two circulations may be to deel measured with doppler ultrasound and provide diagnostic information.

scholarly journals Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 756-760 ◽  
Author(s):  
Toshimi Kaido ◽  
Akira Yoshikawa ◽  
Shin-ichi Seto ◽  
Shoji Yamaoka ◽  
Maki Sato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Portal Branch ◽  
Extensive Hepatectomy ◽  
Portal Branch Ligation ◽  
Hepatocyte Growth

Increase in hepatic blood flow and cardiac output during dopamine infusion in man

1981 ◽  
Vol 9 (1) ◽  
pp. 14-16 ◽  
Author(s):  
P. MAESTRACCI ◽  
D. GRIMAUD ◽  
N. LIVRELLI ◽  
F. PHILIP ◽  
C. DOLISI
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Hepatic Blood Flow ◽  
Dopamine Infusion
Sign in / Sign up

Export Citation Format

Share Document