In situ synthesized lactobionic acid conjugated NMOFs, a smart material for imaging and targeted drug delivery in hepatocellular carcinoma

2019 ◽  
Vol 98 ◽  
pp. 772-781 ◽  
Author(s):  
Arpita Samui ◽  
Kunal Pal ◽  
Parimal Karmakar ◽  
Sumanta Kumar Sahu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Smart Material ◽  
Lactobionic Acid ◽  
Targeted Drug

scholarly journals Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for Hepatocellular Carcinoma-Targeted Drug Delivery

2020 ◽  
Vol Volume 15 ◽  
pp. 821-837 ◽  
Author(s):  
Amr Hefnawy ◽  
Islam H Khalil ◽  
Kholoud Arafa ◽  
Marwan Emara ◽  
Ibrahim M El-Sherbiny
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Core Shell ◽  
Targeted Drug

Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

2020 ◽  
Vol 8 (21) ◽  
pp. 4648-4659 ◽  
Author(s):  
Long Wu ◽  
Wei Xie ◽  
Hui-Ming Zan ◽  
Zhongzhong Liu ◽  
Ganggang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Platelet Membrane ◽  
Coated Nanoparticles ◽  
Controllable Release ◽  
Targeted Drug

Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.

In situ crosslinked smart polypeptide nanoparticles for multistage responsive tumor-targeted drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 5985-5995 ◽  
Author(s):  
Huqiang Yi ◽  
Peng Liu ◽  
Nan Sheng ◽  
Ping Gong ◽  
Yifan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug

Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma

2020 ◽  
Vol 8 (1) ◽  
pp. 189-200 ◽  
Author(s):  
Jianghua Li ◽  
Yang Zhang ◽  
Chao Cai ◽  
Xiaozhi Rong ◽  
Meng Shao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Severe Pain ◽  
Chemotherapeutic Drugs ◽  
Collaborative Assembly ◽  
Systemic Side Effects ◽  
Targeted Drug ◽  
Low Efficiency ◽  
Novel Drug

Hepatocellular carcinoma (HCC) patients suffer from severe pain due to the serious systemic side effects and low efficiency of chemotherapeutic drugs, and it is important to develop novel drug delivery systems to circumvent these issues.

scholarly journals Targeted drug delivery of Methotrexate in situ gels for the treatment of Rheumatoid Arthritis

2020 ◽  
Vol 28 (12) ◽  
pp. 1548-1557 ◽  
Author(s):  
Madhugiri Prakash Venkatesh ◽  
Tegginmat Pramod Kumar ◽  
Deeksha Ramananda Pai
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug

Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH Responsive Hepatocellular Carcinoma-Targeted Drug Delivery

2020 ◽  
Vol 27 ◽  
Author(s):  
Yu-Lan Li ◽  
Xiao-Min Zhu ◽  
Hong Liang ◽  
Chris Orvig ◽  
Zhen-Feng Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Asialoglycoprotein Receptor ◽  
Glycyrrhetinic Acid ◽  
Ph Responsive ◽  
Acid Receptor ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Acid Labile

Background: Hepatocellular carcinoma (HCC) seriously affects human health, especially, it easily develop multi-drug resistance (MDR) result in treatment failure. There is an urgent need to develop highly effective and low-toxicity therapeutic agents to treat HCC and overcome its MDR. Targeted drug delivery systems (DDS) for cancer therapy, including nanoparticles, lipids, micelles and liposomes, have been studied for decades. Recently, more and more attentions have been paid to multifunctional DDS containing various ligands such as polymer moieties, targeting moieties, and acid-labile linkages. The polymer moieties such as poly(ethylene glycol) (PEG), chitosan, hyaluronic acid, pullulan, poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO) protect DDS from degradation. Asialoglycoprotein receptor (ASGPR) and glycyrrhetinic acid receptor (GAR) are the most often used as the targeting moieties, which are overexpressed on hepatocytes. Acid-labile linkage, catering for the pH difference between tumor cells and normal tissue, has been utilized to release drugs at tumor tissue. Objectives: This review provides a summary on the recent progresses in ASGPR and GAR-mediated and/or pH responsive HCC-targeted drug delivery. Conclusion: The multifunctional DDS may prolong systemic circulation, continuously release drugs, increase drugs tumor accumulation at targeted site,enhance anticancer effect, and reduce side effects both in vitro or vivo. But it is rarely used to investigate MDR of HCC, it is need to further study before in clinical.

scholarly journals Supramolecular nanomotors with “pH taxis” for active drug delivery in the tumor microenvironment

Nanoscale ◽  
2020 ◽  
Vol 12 (44) ◽  
pp. 22495-22501
Author(s):  
Motilal Mathesh ◽  
Jiawei Sun ◽  
Frans van der Sandt ◽  
Daniela A. Wilson
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Active Drug ◽  
Ph Gradient ◽  
Supramolecular Architecture ◽  
Targeted Drug ◽  
Drug Delivery Applications

Supramolecular architecture-based truly “pH taxis” exhibiting nanomotors are fabricated by in-situ grown CaCO3 particles, which can sense the endogenously present pH gradient in HeLa cells making them suitable for targeted drug delivery applications.

In situ dose amplification by apoptosis-targeted drug delivery

2011 ◽  
Vol 154 (3) ◽  
pp. 214-217 ◽  
Author(s):  
Kai Wang ◽  
Moon-Hee Na ◽  
Allan S. Hoffman ◽  
Gayong Shim ◽  
Su-Eun Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug
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