Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma

2020 ◽  
Vol 8 (1) ◽  
pp. 189-200 ◽  
Author(s):  
Jianghua Li ◽  
Yang Zhang ◽  
Chao Cai ◽  
Xiaozhi Rong ◽  
Meng Shao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Severe Pain ◽  
Chemotherapeutic Drugs ◽  
Collaborative Assembly ◽  
Systemic Side Effects ◽  
Targeted Drug ◽  
Low Efficiency ◽  
Novel Drug

Hepatocellular carcinoma (HCC) patients suffer from severe pain due to the serious systemic side effects and low efficiency of chemotherapeutic drugs, and it is important to develop novel drug delivery systems to circumvent these issues.

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

scholarly journals Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for Hepatocellular Carcinoma-Targeted Drug Delivery

2020 ◽  
Vol Volume 15 ◽  
pp. 821-837 ◽  
Author(s):  
Amr Hefnawy ◽  
Islam H Khalil ◽  
Kholoud Arafa ◽  
Marwan Emara ◽  
Ibrahim M El-Sherbiny
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Core Shell ◽  
Targeted Drug

Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

2020 ◽  
Vol 8 (21) ◽  
pp. 4648-4659 ◽  
Author(s):  
Long Wu ◽  
Wei Xie ◽  
Hui-Ming Zan ◽  
Zhongzhong Liu ◽  
Ganggang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Platelet Membrane ◽  
Coated Nanoparticles ◽  
Controllable Release ◽  
Targeted Drug

Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.

Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH Responsive Hepatocellular Carcinoma-Targeted Drug Delivery

2020 ◽  
Vol 27 ◽  
Author(s):  
Yu-Lan Li ◽  
Xiao-Min Zhu ◽  
Hong Liang ◽  
Chris Orvig ◽  
Zhen-Feng Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Asialoglycoprotein Receptor ◽  
Glycyrrhetinic Acid ◽  
Ph Responsive ◽  
Acid Receptor ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Acid Labile

Background: Hepatocellular carcinoma (HCC) seriously affects human health, especially, it easily develop multi-drug resistance (MDR) result in treatment failure. There is an urgent need to develop highly effective and low-toxicity therapeutic agents to treat HCC and overcome its MDR. Targeted drug delivery systems (DDS) for cancer therapy, including nanoparticles, lipids, micelles and liposomes, have been studied for decades. Recently, more and more attentions have been paid to multifunctional DDS containing various ligands such as polymer moieties, targeting moieties, and acid-labile linkages. The polymer moieties such as poly(ethylene glycol) (PEG), chitosan, hyaluronic acid, pullulan, poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO) protect DDS from degradation. Asialoglycoprotein receptor (ASGPR) and glycyrrhetinic acid receptor (GAR) are the most often used as the targeting moieties, which are overexpressed on hepatocytes. Acid-labile linkage, catering for the pH difference between tumor cells and normal tissue, has been utilized to release drugs at tumor tissue. Objectives: This review provides a summary on the recent progresses in ASGPR and GAR-mediated and/or pH responsive HCC-targeted drug delivery. Conclusion: The multifunctional DDS may prolong systemic circulation, continuously release drugs, increase drugs tumor accumulation at targeted site,enhance anticancer effect, and reduce side effects both in vitro or vivo. But it is rarely used to investigate MDR of HCC, it is need to further study before in clinical.

scholarly journals NANOSUSPENSION: AN OVERVIEW

2017 ◽  
Vol 9 (3) ◽  
pp. 19
Author(s):  
Smita S. Aher ◽  
Sagar T. Malsane ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
High Pressure Homogenization ◽  
Specific Drug ◽  
Site Specific ◽  
Promising Strategy ◽  
Media Milling ◽  
Efficient Delivery ◽  
Targeted Drug ◽  
Novel Drug

Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in theOcular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

scholarly journals MAGNETIC MICROSPHERE AN EMERGING DRUG DELIVERY SYSTEM

2017 ◽  
Vol 10 (6) ◽  
pp. 54 ◽  
Author(s):  
Diksha Sharma ◽  
Abhishek Sharma
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
The Body ◽  
Magnetic Microspheres ◽  
Magnetic Microsphere ◽  
Targeted Drug ◽  
Novel Drug

  The drug delivery system has been advanced to release the drug according to the body requirement during the entire period of treatment and also for the delivery at the targeted site. Several novel drug delivery systems have emerged encompassing different route of administration to achieve controlled and targeted drug delivery, magnetic microsphere carrier being one of them. Magnetic microsphere is an alternative to traditional radiation methods. As the traditional radiation methods use highly penetrating radiation that is absorbed throughout the body and cause side effects hence its use is limited. Therefore, a safe and effective alternate is needed like magnetic microsphere. The excessive circulating drug particles are minimized by this delivery system. Moreover, the aim of specific targeting is to enhance the effectiveness of drug delivery and at the same time to lessen the toxicity and side effects. Magnetic carriers receive magnetic responses to a magnetic field from incorporated materials that are used for magnetic microsphere are chitosan, dextran, etc. One of the most utilized magnetic microspheres is serum albumine whether from human or other suitable animals. Drug release from the albumin microsphere can be controlled by various stabilization procedures. Overall, the targeted magnetic microsphere is much valuable novel drug delivery system for what more work have to be done. By knowing the importance of all this, the present paper reviews the mechanism, preparation, and applications of magnetic microspheres. As the targeted drug delivery system implies selective and effective localization of drug into the target at therapeutic concentrations with limited access to non-target sites. Magnetic microspheres hold great promises for reaching the goal of controlled and site-specific drug delivery.

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