In vitro cytotoxicity and phototoxicity of surface-modified gold nanoparticles associated with neutral red as a potential drug delivery system in phototherapy

2016 ◽  
Vol 65 ◽  
pp. 199-204 ◽  
Author(s):  
Tanira V. Verissimo ◽  
Naiara T. Santos ◽  
Jaqueline R. Silva ◽  
Ricardo B. Azevedo ◽  
Anderson J. Gomes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Neutral Red ◽  
In Vitro Cytotoxicity ◽  
Potential Drug ◽  
Surface Modified

Excipient effects on in vitro cytotoxicity of a novel paclitaxel self‐emulsifying drug delivery system

2003 ◽  
Vol 92 (12) ◽  
pp. 2411-2418 ◽  
Author(s):  
Neslihan Gursoy ◽  
Jean‐Sebastien Garrigue ◽  
Alain Razafindratsita ◽  
Gregory Lambert ◽  
Simon Benita ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Cytotoxicity

scholarly journals A New NT4 Peptide-Based Drug Delivery System for Cancer Treatment

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1088 ◽  
Author(s):  
Jlenia Brunetti ◽  
Sara Piantini ◽  
Marco Fragai ◽  
Silvia Scali ◽  
Giulia Cipriani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
In Vitro Cytotoxicity ◽  
Cancer Tissue ◽  
Chemotherapy Drugs

The development of selective tumor targeting agents to deliver multiple units of chemotherapy drugs to cancer tissue would improve treatment efficacy and greatly advance progress in cancer therapy. Here we report a new drug delivery system based on a tetrabranched peptide known as NT4, which is a promising cancer theranostic by virtue of its high cancer selectivity. We developed NT4 directly conjugated with one, two, or three units of paclitaxel and an NT4-based nanosystem, using NIR-emitting quantum dots, loaded with the NT4 tumor-targeting agent and conjugated with paclitaxel, to obtain a NT4-QD-PTX nanodevice designed to simultaneously detect and kill tumor cells. The selective binding and in vitro cytotoxicity of NT4-QD-PTX were higher than for unlabeled QD-PTX when tested on the human colon adenocarcinoma cell line HT-29. NT4-QD-PTX tumor-targeted nanoparticles can be considered promising for early tumor detection and for the development of effective treatments combining simultaneous therapy and diagnosis.

Shikonin-loaded liposomes as a new drug delivery system: Physicochemical characterization and in vitro cytotoxicity

2011 ◽  
Vol 113 (9) ◽  
pp. 1113-1123 ◽  
Author(s):  
Konstantinos N. Kontogiannopoulos ◽  
Andreana N. Assimopoulou ◽  
Konstantinos Dimas ◽  
Vassilios P. Papageorgiou
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Physicochemical Characterization ◽  
In Vitro Cytotoxicity ◽  
New Drug

Development and in vitro cytotoxicity of microparticle drug delivery system for proteins using l-tyrosine polyphosphate

2009 ◽  
Vol 287 (10) ◽  
pp. 1195-1205 ◽  
Author(s):  
Parth N. Shah ◽  
Anthony A. Puntel ◽  
Stephanie T. Lopina ◽  
Yang H. Yun
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Cytotoxicity

scholarly journals A Smart Core-Crosslinked Supramolecular Drug Delivery System (SDDS) Enabled by Pendant Cyclodextrins Encapsulation of Drug Dimers via Host-Guest Interaction

Biosensors ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 306
Author(s):  
Xin Xing ◽  
Zhijun Guo ◽  
Yue Su ◽  
Zhen Yang ◽  
Jiwen Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Micelles ◽  
Dynamic Equilibrium ◽  
Drug Loading ◽  
In Vitro Cytotoxicity ◽  
Stimuli Responsive ◽  
Anti Cancer

Owing to poor aqueous solubility and low delivery efficiency, most of anti-cancer chemodrugs depend on various smart drug delivery platforms to enhance the treatment efficacy. Herein, a stimuli-responsive supramolecular drug delivery system (SDDS) is developed based on polymeric cyclodextrins (PCD) which crosslinked by stimuli-cleavable drug dimers via host-guest interaction. PEGylated PCD was precisely controlled synthesized by ring-opening polymerization and azide-alkyne click chemistry, and two doxorubicins (DOX) were linked with a disulfide bond to form a drug dimer (ss-DOX). They then co-assembled into supramolecular micelles. Drug dimers were utilized as cross-linkers to stabilize the micelles. The drug loading efficiency was very high that could be up to 98%. The size and morphology were measured by DLS and TEM. Owing to the disulfide bonds of drug dimers, these supramolecular micelles were dissociated by treating with dithiothreitol (DTT). In the meanwhile, the free DOXs were recovered and released from cavities of cyclodextrins because of dynamic equilibrium and hydrophilicity changes. The release profile was studied under mimic physiological conditions. Furthermore, in vitro cytotoxicity study showed excellent anti-cancer efficacy of reduced-responsive supramolecular polymeric micelles. Therefore, it can be served as a safe and stimuli-responsive SDDS for cancer therapy.

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