Developing multi-cellular tumor spheroid model (MCTS) in the chitosan/collagen/alginate (CCA) fibrous scaffold for anticancer drug screening

2016 ◽  
Vol 62 ◽  
pp. 215-225 ◽  
Author(s):  
Jian-Zheng Wang ◽  
Yu-Xia Zhu ◽  
Hui-Chao Ma ◽  
Si-Nan Chen ◽  
Ji-Ye Chao ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Tumor Spheroid ◽  
Fibrous Scaffold

Development of an in Vitro Multicellular Tumor Spheroid Model Using Microencapsulation and Its Application in Anticancer Drug Screening and Testing

2008 ◽  
Vol 21 (4) ◽  
pp. 1289-1296 ◽  
Author(s):  
Xulang Zhang ◽  
Wei Wang ◽  
Weiting Yu ◽  
Yubing Xie ◽  
Xiaohui Zhang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Tumor Spheroid ◽  
Multicellular Tumor Spheroid

On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

2019 ◽  
Vol 137 ◽  
pp. 236-254 ◽  
Author(s):  
Nandini Dhiman ◽  
Peter Kingshott ◽  
Huseyin Sumer ◽  
Chandra S. Sharma ◽  
Subha Narayan Rath
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Recent Progress ◽  
Microfluidic Platforms ◽  
On Chip

scholarly journals Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

2020 ◽  
Vol 8 ◽  
Author(s):  
Kristina V. Kitaeva ◽  
Catrin S. Rutland ◽  
Albert A. Rizvanov ◽  
Valeriya V. Solovyeva
Keyword(s):  
Cell Culture ◽  
Anticancer Drug ◽  
Drug Screening ◽  
In Vitro Test ◽  
Test Systems ◽  
Vitro Test

A novel design of microfluidic platform for metronomic combinatorial chemotherapy drug screening based on 3D tumor spheroid model

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Sharanya Sankar ◽  
Viraj Mehta ◽  
Subhashini Ravi ◽  
Chandra Shekhar Sharma ◽  
Subha Narayan Rath
Keyword(s):  
Drug Screening ◽  
Tumor Spheroid ◽  
Microfluidic Platform ◽  
Chemotherapy Drug ◽  
Novel Design

Potential of zebrafish for anticancer drug screening

2008 ◽  
Vol 3 (12) ◽  
pp. 1451-1460 ◽  
Author(s):  
Leonard I Zon ◽  
Xiuning Le
Keyword(s):  
Anticancer Drug ◽  
Drug Screening

scholarly journals PROSPECTIVE AND RETROSPECTIVE ANIMAL MODEL USED IN THE PHARMACOLOGICAL SCREENING OF ANTI-CANCER DRUG

2018 ◽  
Vol 10 (4) ◽  
pp. 13
Author(s):  
Shamima Nasreen Ahmed ◽  
Biswajit Das ◽  
Jashabir Chakraborty
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Rapid Development ◽  
The Body ◽  
Cytotoxic Agents ◽  
Cancer Drug ◽  
Tumor Models ◽  
Preclinical Screening ◽  
Anticancer Drug Development

Cancer is a disease characterized by uncontrolled proliferation of cells that have transformed from the normal cells of the body. The widely used cancer drugs suffers from the drawback of high toxicity not within the reach of a common man. This urgently necessitating the screening of these compounds. This review focuses on the major contributions of preclinical screening models to anticancer drug development over the years till recent times, from the empirical drug screening of cytotoxic agents against uncharacterized tumor models to the target-orientated drug screening of agents with defined mechanisms of action,, a general transition has been observed. The newer approaches to anticancer drug development involve the molecular characterization of models along with an appreciation of the pharmacodynamics and pharmacokinetic properties of compounds [e. g., the US National Cancer Institute (NCI) in vitro 60-cell line panel, hollow fibre assay, and s. c. xenograft]. In vivo tumor models including orthotopic, metastatic, and genetically engineered mouse models are also reviewed. The preclinical screening efforts of the European are also included. In 2015 with the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer drug since 1970 the European Organisation for Research and Treatment of Cancer and Cancer Research UK, have been collaborating with the NCI in the acquisition and screening of compounds.

Anticancer drug discovery using multicellular tumor spheroid models

2019 ◽  
Vol 14 (3) ◽  
pp. 289-301 ◽  
Author(s):  
Michele Zanoni ◽  
Sara Pignatta ◽  
Chiara Arienti ◽  
Massimiliano Bonafè ◽  
Anna Tesei
Keyword(s):  
Drug Discovery ◽  
Anticancer Drug ◽  
Tumor Spheroid ◽  
Multicellular Tumor Spheroid ◽  
Anticancer Drug Discovery

Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments

Lab on a Chip ◽  
2011 ◽  
Vol 11 (14) ◽  
pp. 2333 ◽  
Author(s):  
Lo-Chang Hsiung ◽  
Chi-Ling Chiang ◽  
Chen-Ho Wang ◽  
Yu-Hsu Huang ◽  
Ching-Te Kuo ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Microarray Chip
Sign in / Sign up

Export Citation Format

Share Document