Dielectrophoresis-based cellular microarray chip for anticancer drug screening in perfusion microenvironments

Lab on a Chip ◽  
2011 ◽  
Vol 11 (14) ◽  
pp. 2333 ◽  
Author(s):  
Lo-Chang Hsiung ◽  
Chi-Ling Chiang ◽  
Chen-Ho Wang ◽  
Yu-Hsu Huang ◽  
Ching-Te Kuo ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Microarray Chip

On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

2019 ◽  
Vol 137 ◽  
pp. 236-254 ◽  
Author(s):  
Nandini Dhiman ◽  
Peter Kingshott ◽  
Huseyin Sumer ◽  
Chandra S. Sharma ◽  
Subha Narayan Rath
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Recent Progress ◽  
Microfluidic Platforms ◽  
On Chip

scholarly journals Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

2020 ◽  
Vol 8 ◽  
Author(s):  
Kristina V. Kitaeva ◽  
Catrin S. Rutland ◽  
Albert A. Rizvanov ◽  
Valeriya V. Solovyeva
Keyword(s):  
Cell Culture ◽  
Anticancer Drug ◽  
Drug Screening ◽  
In Vitro Test ◽  
Test Systems ◽  
Vitro Test

Potential of zebrafish for anticancer drug screening

2008 ◽  
Vol 3 (12) ◽  
pp. 1451-1460 ◽  
Author(s):  
Leonard I Zon ◽  
Xiuning Le
Keyword(s):  
Anticancer Drug ◽  
Drug Screening

scholarly journals PROSPECTIVE AND RETROSPECTIVE ANIMAL MODEL USED IN THE PHARMACOLOGICAL SCREENING OF ANTI-CANCER DRUG

2018 ◽  
Vol 10 (4) ◽  
pp. 13
Author(s):  
Shamima Nasreen Ahmed ◽  
Biswajit Das ◽  
Jashabir Chakraborty
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Rapid Development ◽  
The Body ◽  
Cytotoxic Agents ◽  
Cancer Drug ◽  
Tumor Models ◽  
Preclinical Screening ◽  
Anticancer Drug Development

Cancer is a disease characterized by uncontrolled proliferation of cells that have transformed from the normal cells of the body. The widely used cancer drugs suffers from the drawback of high toxicity not within the reach of a common man. This urgently necessitating the screening of these compounds. This review focuses on the major contributions of preclinical screening models to anticancer drug development over the years till recent times, from the empirical drug screening of cytotoxic agents against uncharacterized tumor models to the target-orientated drug screening of agents with defined mechanisms of action,, a general transition has been observed. The newer approaches to anticancer drug development involve the molecular characterization of models along with an appreciation of the pharmacodynamics and pharmacokinetic properties of compounds [e. g., the US National Cancer Institute (NCI) in vitro 60-cell line panel, hollow fibre assay, and s. c. xenograft]. In vivo tumor models including orthotopic, metastatic, and genetically engineered mouse models are also reviewed. The preclinical screening efforts of the European are also included. In 2015 with the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer drug since 1970 the European Organisation for Research and Treatment of Cancer and Cancer Research UK, have been collaborating with the NCI in the acquisition and screening of compounds.

Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening

Biomaterials ◽  
2013 ◽  
Vol 34 (29) ◽  
pp. 7117-7126 ◽  
Author(s):  
Limin Zhang ◽  
Liming Wang ◽  
Yili Hu ◽  
Zhigang Liu ◽  
Yuan Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Gold Nanorods ◽  
Drug Screening ◽  
Metabolic Effects

Development of an in Vitro Multicellular Tumor Spheroid Model Using Microencapsulation and Its Application in Anticancer Drug Screening and Testing

2008 ◽  
Vol 21 (4) ◽  
pp. 1289-1296 ◽  
Author(s):  
Xulang Zhang ◽  
Wei Wang ◽  
Weiting Yu ◽  
Yubing Xie ◽  
Xiaohui Zhang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Tumor Spheroid ◽  
Multicellular Tumor Spheroid

CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening

2008 ◽  
Vol 18 (9) ◽  
pp. 771-776 ◽  
Author(s):  
Ching-Fong Liao ◽  
Shue-Fen Luo ◽  
Chin-Shaw Tsai ◽  
Tang-Yi Tsao ◽  
Shun-Liang Chen ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
High Sensitivity ◽  
Chemotherapeutic Drug ◽  
Drug Induced

scholarly journals Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

Oncotarget ◽  
2015 ◽  
Vol 6 (25) ◽  
pp. 21255-21267 ◽  
Author(s):  
Maria A. Theodoraki ◽  
Celso O. Rezende ◽  
Oraphin Chantarasriwong ◽  
Adriana D. Corben ◽  
Emmanuel A. Theodorakis ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Cell Model
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