Hybrid nanostructured drug carrier with tunable and controlled drug release

2012 ◽  
Vol 32 (6) ◽  
pp. 1704-1709 ◽  
Author(s):  
D. Depan ◽  
R.D.K. Misra
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release

scholarly journals Preparation and Drug-Release Kinetics of Porous Poly(L-lactic acid)/Rifampicin Blend Particles

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takashi Sasaki ◽  
Hiroaki Matsuura ◽  
Kazuki Tanaka
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Solution Concentration ◽  
Porous Polymer ◽  
High Porosity ◽  
Original Solution ◽  
Kinetics Of

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 54 (25) ◽  
pp. 7376-7380 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 127 (25) ◽  
pp. 7484-7488 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

Controlled Drug Release from Biodegradable Bone Fillers

2012 ◽  
Vol 430-432 ◽  
pp. 677-680
Author(s):  
Yong Li Zhang ◽  
Chen Xu ◽  
Zhi Ming Sun ◽  
Mao Cong Yi ◽  
Yu Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Drug Release Rate ◽  
Rapid Degradation ◽  
Bone Filler ◽  
Structure Of Coatings

Plaster of Pairs is a common used implanting material. However, its rapid degradation or drug releasing rate as a bone filler or drug carrier does not meet the requirement of clinic application. In this paper, plaster of Pairs bone fillers loaded with drug was prepared and their degradation and the drug release period were adjusted by coating their surface with polymers. The results show that the structure of coatings can effectively control the degradation period of the bone fillers, and consequently the drug release rate.

scholarly journals Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

2019 ◽  
Vol 4 (4) ◽  
pp. 155-162
Author(s):  
Fatemeh Dalayi ◽  
Leila Hajiaghababaei ◽  
Alireza Badiei ◽  
Elham Boorboor Azimi ◽  
Mohammad Reza Ganjali ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Ph Value ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Nanoporous Silica ◽  
Release Process ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 80896-80904 ◽  
Author(s):  
Hongliang Cao ◽  
Huajie Song ◽  
Debiao Xie ◽  
Chao Chen ◽  
Xin Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ene Reaction

A glutathione (GSH) responsive drug carrier is prepared that relies on the thio–ene reaction of olefinic bonds and GSH.

pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

2014 ◽  
Vol 2 (33) ◽  
pp. 5409-5418 ◽  
Author(s):  
Bo Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
Yum-Shing Wong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cell Organelles ◽  
Shape Transformation ◽  
Anticancer Efficacy

A cancer-targeted and structure-transformable drug delivery system has been constructed, which displays enhanced anticancer efficacy and exhibits the characteristics of shape transformation and pH-controlled drug release under acidifying cell organelles.

Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion

2015 ◽  
Vol 51 (29) ◽  
pp. 6422-6425 ◽  
Author(s):  
Seiichi Ohta ◽  
Kentaro Yamura ◽  
Susumu Inasawa ◽  
Yukio Yamaguchi
Keyword(s):  
Quantum Dots ◽  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Silicon Quantum Dots ◽  
Release System ◽  
Drug Release System

A novel, controlled drug-release system was developed based on aggregation/dispersion of silicon quantum dots (Si-QDs) in response to a change in the pH environment.

scholarly journals Plasmon-Enhanced Controlled Drug Release from Ag-PMA Capsules

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2267 ◽  
Author(s):  
Giulia Neri ◽  
Carmelo Corsaro ◽  
Enza Fazio
Keyword(s):  
Drug Release ◽  
Laser Irradiation ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Experimental Conditions ◽  
Power Intensity ◽  
Acid Sodium Salt ◽  
Demand Control ◽  
Smart Drug

Silver (Ag)-grafted PMA (poly-methacrylic acid, sodium salt) nanocomposite loaded with sorafenib tosylate (SFT), an anticancer drug, showed good capability as a drug carrier allowing on-demand control of the dose, timing and duration of the drug release by laser irradiation stimuli. In this study, the preparation of Ag-PMA capsules loaded with SFT by using sacrificial silica microparticles as templates was reported. A high drug loading (DL%) of ∼13% and encapsulation efficiency (EE%) of about 76% were obtained. The photo-release profiles were regulated via the adjustment of light wavelength and power intensity. A significant improvement of SFT release (14% vs. 21%) by comparing SFT-Ag-PMA capsules with Ag-PMA colloids under the same experimental conditions was observed. Moreover, an increase of drug release by up to 35% was reached by tuning the laser irradiation wavelength near to Ag nanoparticles’ surface plasmon resonance (SPR). These experimental results together with more economical use of the active component suggest the potentiality of SFT-Ag-PMA capsules as a smart drug delivery system.

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