Controlled drug release from a novel drug carrier of calcium polyphosphate/chitosan/aldehyde alginate scaffolds containing chitosan microspheres

RSC Advances ◽  
2014 ◽  
Vol 4 (47) ◽  
pp. 24810 ◽  
Author(s):  
Yaping Wang ◽  
Xu Wang ◽  
Li Li ◽  
Zhipeng Gu ◽  
Xixun Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Chitosan Microspheres ◽  
Calcium Polyphosphate ◽  
Novel Drug

scholarly journals Preparation and Drug-Release Kinetics of Porous Poly(L-lactic acid)/Rifampicin Blend Particles

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Takashi Sasaki ◽  
Hiroaki Matsuura ◽  
Kazuki Tanaka
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Solution Concentration ◽  
Porous Polymer ◽  
High Porosity ◽  
Original Solution ◽  
Kinetics Of

Porous polymer spheres are promising materials as carriers for controlled drug release. As a new drug-carrier material, blend particles composed of poly(L-lactic acid) (PLLA) and rifampicin were developed using the freeze-drying technique. The blend particles exhibit high porosity with a specific surface area of 10–40 m2 g−1. Both the size and porosity of the particles depend on the concentration of the original solution and on the method of freezing. With respect to the latter, we used the drop method (pouring the original solution dropwise into liquid nitrogen) and the spray method (freezing a mist of the original solution). The release kinetics of rifampicin from the blend particles into water depends significantly on the morphology of the blend particles. The results show that the release rate can be controlled to a great extent by tuning the size and porosity of the blend particles, both of which are varied by parameters such as the solution concentration and the method of freezing.

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 54 (25) ◽  
pp. 7376-7380 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release

2015 ◽  
Vol 127 (25) ◽  
pp. 7484-7488 ◽  
Author(s):  
Chongbo Ma ◽  
Ye Shi ◽  
Danilo A. Pena ◽  
Lele Peng ◽  
Guihua Yu
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Carrier Model ◽  
Thermally Responsive ◽  
General Drug

Formulation and Evaluation of Gastroretentive Nanoparticles of Repaglinide

2014 ◽  
Vol 7 (1) ◽  
pp. 2363-2370
Author(s):  
P M Jamkar ◽  
K N Gujar ◽  
S B Nemmaniwar ◽  
N B Kulkarni
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Sodium Alginate ◽  
Encapsulation Efficiency ◽  
Research Work ◽  
Crosslinking Agent ◽  
Controlled Drug Release ◽  
Dsc Studies ◽  
Ft Ir ◽  
Novel Drug

Controlled drug release system is one of the most favourable technique of novel drug delivery system owing to its reproducibility and ease of formulation. Nanotechnology is very useful for controlling the drug release and thus improving the pharmacokinetic and pharmacodynamic properties of the drug. The technique improves patient compliance by reducing both dose and the frequency of administration and thus minimizing the local as well as systemic toxic effects. The aim of the present research work was to formulate and evaluate gastroretentive nanoparticles of Repaglinide, an anti-diabetic drug by using the ionotropic gelation method. Repaglinide has a very short half-life of 1 hour with bioavailability 56%. Sustained release mucoadhesive nanoparticles of Repaglinide were prepared to increase the drug residence time in gastrointestinal tract and thus improving the bioavailability of drug. The mucoadhesive nanoparticles were prepared by using chitosan and sodium alginate as polymers; calcium chloride as the crosslinking agent. Different formulations were prepared with varying concentrations of chitosan and sodium alginate in order to achieve the optimum particle size and maximum encapsulation efficiency. The particle size of nanoparticles was found to be in the range of 300 nm to 756 nm. Drug encapsulation efficiency ranged between 56% to 80% with controlled drug release upto 88% in phosphate buffer pH 7.4 and 75% drug release in 0.1N HCl in 12 hrs. FT-IR and DSC studies showed that the drug and polymers were compatible. The results of swelling study and bioadhesive strength indicated that optimized formulation exhibited excellent mucoadhesive properties

Controlled Drug Release from Biodegradable Bone Fillers

2012 ◽  
Vol 430-432 ◽  
pp. 677-680
Author(s):  
Yong Li Zhang ◽  
Chen Xu ◽  
Zhi Ming Sun ◽  
Mao Cong Yi ◽  
Yu Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Drug Release Rate ◽  
Rapid Degradation ◽  
Bone Filler ◽  
Structure Of Coatings

Plaster of Pairs is a common used implanting material. However, its rapid degradation or drug releasing rate as a bone filler or drug carrier does not meet the requirement of clinic application. In this paper, plaster of Pairs bone fillers loaded with drug was prepared and their degradation and the drug release period were adjusted by coating their surface with polymers. The results show that the structure of coatings can effectively control the degradation period of the bone fillers, and consequently the drug release rate.

scholarly journals Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

2019 ◽  
Vol 4 (4) ◽  
pp. 155-162
Author(s):  
Fatemeh Dalayi ◽  
Leila Hajiaghababaei ◽  
Alireza Badiei ◽  
Elham Boorboor Azimi ◽  
Mohammad Reza Ganjali ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Ph Value ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Nanoporous Silica ◽  
Release Process ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 80896-80904 ◽  
Author(s):  
Hongliang Cao ◽  
Huajie Song ◽  
Debiao Xie ◽  
Chao Chen ◽  
Xin Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ene Reaction

A glutathione (GSH) responsive drug carrier is prepared that relies on the thio–ene reaction of olefinic bonds and GSH.

A cross-linking graphene oxide–polyethyleneimine hybrid film containing ciprofloxacin: one-step preparation, controlled drug release and antibacterial performance

2015 ◽  
Vol 3 (8) ◽  
pp. 1605-1611 ◽  
Author(s):  
Tiefan Huang ◽  
Lin Zhang ◽  
Huanlin Chen ◽  
Congjie Gao
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Release ◽  
Hybrid Film ◽  
Controlled Drug Release ◽  
Cross Linking ◽  
Antibacterial Performance ◽  
One Step ◽  
Novel Drug Delivery System ◽  
Novel Drug

A graphene oxide film was cross-linked by polyethyleneimine as a novel drug delivery system which showed excellent antibacterial performance.

Chitosan-based magnetic/fluorescent nanocomposites for cell labelling and controlled drug release

2017 ◽  
Vol 41 (4) ◽  
pp. 1736-1743 ◽  
Author(s):  
Yongling Ding ◽  
Hong Yin ◽  
Shirley Shen ◽  
Kangning Sun ◽  
Futian Liu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Cell Labelling ◽  
Chitosan Matrix ◽  
Novel Drug Delivery System ◽  
Novel Drug

A novel drug delivery system, containing functional Fe3O4, CdTe@ZnS QDs, doxorubicin and a chitosan matrix, was designed via a polymer crosslinking method.

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