Nanoscale characterization of bone–implant interface and biomechanical modulation of bone ingrowth

2007 ◽  
Vol 27 (3) ◽  
pp. 382-393 ◽  
Author(s):  
Paul A. Clark ◽  
Andrew M. Clark ◽  
Anthony Rodriguez ◽  
Mohammad A. Hussain ◽  
Jeremy J. Mao
Keyword(s):  
Bone Ingrowth ◽  
Bone Implant ◽  
Nanoscale Characterization

Osteoclast and osteoblast response to strontium-doped struvite coatings on titanium for improved bone integration

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Claus Moseke ◽  
Katharina Wimmer ◽  
Markus Meininger ◽  
Julia Zerweck ◽  
Cornelia Wolf-Brandstetter ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Osteoclast Differentiation ◽  
Inhibitory Effect ◽  
Osteoclast Formation ◽  
Strontium Nitrate ◽  
Bone Implant ◽  
Electrochemically Deposited ◽  
Bone Integration ◽  
Titanium Substrates

AbstractTo develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4·6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. It was expected and observed that osteoclast activity surrounding the implant was inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr2+ had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.

Nanoscale characterization of powder materials by atom probe tomography

2011 ◽  
Vol 208 (2) ◽  
pp. 260-265 ◽  
Author(s):  
R. Larde ◽  
J. Bran ◽  
M. Jean ◽  
J.M. Le Breton
Keyword(s):  
Atom Probe Tomography ◽  
Atom Probe ◽  
Powder Materials ◽  
Nanoscale Characterization

scholarly journals Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/borax /CaCO3 and Demineralized Bone Matrix

2021 ◽  
Author(s):  
Daniela Medrano-David ◽  
Aura Maria Lopera ◽  
Martha Elena Londoño ◽  
Pedronel Araque-Marín
Keyword(s):  
Bone Substitute ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Particulate Material ◽  
Bone Tissue Regeneration ◽  
Bone Implant ◽  
Injectable Scaffold ◽  
The World ◽  
Demineralized Bone

The occurrence of bone-related disorders and diseases has increased dramatically in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision, in addition, these particles are susceptible to migrate to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill the bone defect. The aim of this research is to develop a DBM carrier with such viscoelastic properties to obtain an injectable bone substitute (IBS). The DBM carrier developed consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by the injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results show that the developed material has great potential to be used in bone tissue regeneration

scholarly journals Micro- and nanoscale characterization of different natural biomaterials for ocular surface regeneration

2020 ◽  
Author(s):  
Gamze DERELİ CAN ◽  
Atakan TEVLEK ◽  
Mehmet Erol CAN ◽  
Elif ÖNCÜ ◽  
Halil Murat AYDIN ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Nanoscale Characterization ◽  
Surface Regeneration

Nanoscale characterization of silica soots and aluminium solution doping in optical fibre fabrication

2006 ◽  
Vol 352 (36-37) ◽  
pp. 3799-3807 ◽  
Author(s):  
F.Z. Tang ◽  
P. McNamara ◽  
G.W. Barton ◽  
S.P. Ringer
Keyword(s):  
Optical Fibre ◽  
Nanoscale Characterization ◽  
Solution Doping

Advances in nanoscale characterization of refined nanoporous gold

2018 ◽  
Vol 283 ◽  
pp. 611-618 ◽  
Author(s):  
Ayman A. El-Zoka ◽  
Brian Langelier ◽  
Andreas Korinek ◽  
Gianluigi A. Botton ◽  
Roger C. Newman
Keyword(s):  
Nanoporous Gold ◽  
Nanoscale Characterization
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