A next-generation, flow-diverting implant used to treat brain aneurysms: in vitro evaluation of magnetic field interactions, heating and artifacts at 3-T

2013 ◽  
Vol 31 (1) ◽  
pp. 145-149 ◽  
Author(s):  
Alexandra M. Karacozoff ◽  
Frank G. Shellock ◽  
Ajay K. Wakhloo
Keyword(s):  
Magnetic Field ◽  
Next Generation ◽  
In Vitro Evaluation ◽  
Brain Aneurysms

scholarly journals In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction

2022 ◽  
Vol 23 (2) ◽  
pp. 582
Author(s):  
Alice Sosic ◽  
Giulia Olivato ◽  
Caterina Carraro ◽  
Richard Göttlich ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Chaperone Activity ◽  
Next Generation ◽  
In Vitro Evaluation ◽  
Loop Domain ◽  
Activation Response ◽  
Analytical Approaches ◽  
Bulge Loop ◽  
Hiv 1

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its deserved role in the next generation of pharmaceutical R&D. We have recently probed the trans-activation response (TAR) element, an RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabilizing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analytical approaches for the study of multicomponent RNA-based interactions.

scholarly journals In vitro Evaluation of Bis-3-chloropiperidines as RNA Modulators Targeting TAR and TAR-protein Interaction

2021 ◽  
Author(s):  
Alice Sosic ◽  
Giulia Olivato ◽  
Caterina Carraro ◽  
Richard Göttlich ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Chaperone Activity ◽  
Next Generation ◽  
Response Element ◽  
In Vitro Evaluation ◽  
Loop Domain ◽  
Activation Response ◽  
Hiv 1

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its de-served role in the next-generation area of pharmaceutical R&D. We have recently probed the Trans-Activation Response element (TAR), a RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabiliz-ing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analyti-cal approaches for the study of multicomponent RNA-based interactions.

Next generation coronary CT angiography: in vitro evaluation of 27 coronary stents

2014 ◽  
Vol 24 (11) ◽  
pp. 2953-2961 ◽  
Author(s):  
Tobias Gassenmaier ◽  
Nils Petri ◽  
Thomas Allmendinger ◽  
Thomas Flohr ◽  
David Maintz ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Coronary Ct Angiography ◽  
Coronary Stents ◽  
Next Generation ◽  
In Vitro Evaluation ◽  
Coronary Ct

Next generation macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation

2015 ◽  
Vol 23 (19) ◽  
pp. 6364-6378 ◽  
Author(s):  
Emile Jubeli ◽  
Amanda B. Maginty ◽  
Nada Abdul Khalique ◽  
Liji Raju ◽  
Mohamad Abdulhai ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Lipids ◽  
Next Generation ◽  
In Vitro Evaluation

In vitro evaluation of IL-18 effects in Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A316-A317
Author(s):  
P MAERTEN ◽  
S COLPAERT ◽  
Z LIU ◽  
K GEBOES ◽  
J CEUPPENS ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
In Vitro Evaluation

52: In Vitro Evaluation of Ureteral Stent Compression

2006 ◽  
Vol 175 (4S) ◽  
pp. 18-18
Author(s):  
Kari Hendlin ◽  
Krishna Vedula ◽  
Christina Horn ◽  
Manoj Monga
Keyword(s):  
Ureteral Stent ◽  
In Vitro Evaluation

Purification hemisynthesis of xanthatin derivates and in vitro evaluation of their activity towards farnesyltransferase (PFTase)

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Pinel ◽  
A Landreau ◽  
J Dubois ◽  
G Au do ◽  
F De la Poype ◽  
...  
Keyword(s):  
In Vitro Evaluation
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