Next generation macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation

2015 ◽  
Vol 23 (19) ◽  
pp. 6364-6378 ◽  
Author(s):  
Emile Jubeli ◽  
Amanda B. Maginty ◽  
Nada Abdul Khalique ◽  
Liji Raju ◽  
Mohamad Abdulhai ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Lipids ◽  
Next Generation ◽  
In Vitro Evaluation

Novel macrocyclic and acyclic cationic lipids for gene transfer: Synthesis and in vitro evaluation

2012 ◽  
Vol 22 (14) ◽  
pp. 4686-4692 ◽  
Author(s):  
William P.D. Goldring ◽  
Emile Jubeli ◽  
Rachael A. Downs ◽  
Adam J.S. Johnston ◽  
Nada Abdul Khalique ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Lipids ◽  
In Vitro Evaluation

scholarly journals In Vitro Evaluation of Bis-3-Chloropiperidines as RNA Modulators Targeting TAR and TAR-Protein Interaction

2022 ◽  
Vol 23 (2) ◽  
pp. 582
Author(s):  
Alice Sosic ◽  
Giulia Olivato ◽  
Caterina Carraro ◽  
Richard Göttlich ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Chaperone Activity ◽  
Next Generation ◽  
In Vitro Evaluation ◽  
Loop Domain ◽  
Activation Response ◽  
Analytical Approaches ◽  
Bulge Loop ◽  
Hiv 1

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its deserved role in the next generation of pharmaceutical R&D. We have recently probed the trans-activation response (TAR) element, an RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabilizing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analytical approaches for the study of multicomponent RNA-based interactions.

Synthesis and in Vitro Evaluation of Glutamide-Containing Cationic Lipids for Gene Delivery

2006 ◽  
Vol 17 (6) ◽  
pp. 1530-1536 ◽  
Author(s):  
Vijaya Gopal ◽  
Tekkatte K. Prasad ◽  
Nalam M. Rao ◽  
Makoto Takafuji ◽  
Mohammed M. Rahman ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
In Vitro Evaluation

Cationic lipids bearing succinic-based, acyclic and macrocyclic hydrophobic domains: Synthetic studies and in vitro gene transfer

2017 ◽  
Vol 125 ◽  
pp. 225-232 ◽  
Author(s):  
Emile Jubeli ◽  
Amanda B. Maginty ◽  
Nada Abdul Khalique ◽  
Liji Raju ◽  
David G. Nicholson ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Lipids ◽  
Synthetic Studies

scholarly journals In vitro Evaluation of Bis-3-chloropiperidines as RNA Modulators Targeting TAR and TAR-protein Interaction

2021 ◽  
Author(s):  
Alice Sosic ◽  
Giulia Olivato ◽  
Caterina Carraro ◽  
Richard Göttlich ◽  
Dan Fabris ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Chaperone Activity ◽  
Next Generation ◽  
Response Element ◽  
In Vitro Evaluation ◽  
Loop Domain ◽  
Activation Response ◽  
Hiv 1

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its de-served role in the next-generation area of pharmaceutical R&D. We have recently probed the Trans-Activation Response element (TAR), a RNA stem–bulge–loop domain of the HIV-1 genome with bis-3-chloropiperidines (B-CePs), and revealed the compounds unique behavior in stabiliz-ing TAR structure, thus impairing in vitro the chaperone activity of the HIV-1 nucleocapsid (NC) protein. Seeking to elucidate the determinants of B-CePs inhibition, we have further characterized here their effects on the target TAR and its NC recognition, while developing quantitative analyti-cal approaches for the study of multicomponent RNA-based interactions.

Next generation coronary CT angiography: in vitro evaluation of 27 coronary stents

2014 ◽  
Vol 24 (11) ◽  
pp. 2953-2961 ◽  
Author(s):  
Tobias Gassenmaier ◽  
Nils Petri ◽  
Thomas Allmendinger ◽  
Thomas Flohr ◽  
David Maintz ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Coronary Ct Angiography ◽  
Coronary Stents ◽  
Next Generation ◽  
In Vitro Evaluation ◽  
Coronary Ct

scholarly journals Synthesis of AZT-based cationic lipids and in vitro evaluation of siRNA delivery

2010 ◽  
Vol 46 (9) ◽  
pp. 1523 ◽  
Author(s):  
Sun Min Park ◽  
Jungeun Woo ◽  
Eunmi Jeon ◽  
Byeang Hyean Kim
Keyword(s):  
Sirna Delivery ◽  
Cationic Lipids ◽  
In Vitro Evaluation

scholarly journals Gene transfer by guanidinium-cholesterol cationic lipids into airway epithelial cells in vitro and in vivo

1997 ◽  
Vol 94 (5) ◽  
pp. 1651-1656 ◽  
Author(s):  
N. Oudrhiri ◽  
J.-P. Vigneron ◽  
M. Peuchmaur ◽  
T. Leclerc ◽  
J.-M. Lehn ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Cationic Lipids ◽  
Airway Epithelial

In vitro evaluation of IL-18 effects in Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A316-A317
Author(s):  
P MAERTEN ◽  
S COLPAERT ◽  
Z LIU ◽  
K GEBOES ◽  
J CEUPPENS ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
In Vitro Evaluation
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