Low molecular weight dextran sulfate as complement inhibitor and cytoprotectant in solid organ and islet transplantation

2008 ◽  
Vol 45 (16) ◽  
pp. 4084-4094 ◽  
Author(s):  
Rolf Spirig ◽  
Thusitha Gajanayake ◽  
Olle Korsgren ◽  
Bo Nilsson ◽  
Robert Rieben
Keyword(s):  
Molecular Weight ◽  
Islet Transplantation ◽  
Dextran Sulfate ◽  
Low Molecular Weight ◽  
Solid Organ ◽  
Complement Inhibitor

scholarly journals Low-Molecular-Weight Dextran Sulfate Nanocapsules Inhibit the Adhesion of Helicobacter pylori to Gastric Cells

2019 ◽  
Vol 2 (11) ◽  
pp. 4777-4789 ◽  
Author(s):  
Bianca Menchicchi ◽  
Eleni Savvaidou ◽  
Christian Thöle ◽  
Andreas Hensel ◽  
Francisco M. Goycoolea
Keyword(s):  
Molecular Weight ◽  
Helicobacter Pylori ◽  
Dextran Sulfate ◽  
Low Molecular Weight ◽  
Gastric Cells

scholarly journals Control of IBMIR Induced by Fresh and Cryopreserved Hepatocytes by Low Molecular Weight Dextran Sulfate versus Heparin

2017 ◽  
Vol 26 (1) ◽  
pp. 71-81 ◽  
Author(s):  
Elisabet Gustafson ◽  
Sana Asif ◽  
Huda Kozarcanin ◽  
Graciela Elgue ◽  
Staffan Meurling ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Dextran Sulfate ◽  
Cell Loss ◽  
Hepatocyte Transplantation ◽  
Low Molecular Weight ◽  
Cascade Systems ◽  
Cell Counts ◽  
Compatible Blood

Rapid destruction of hepatocytes after hepatocyte transplantation has hampered the application of this procedure clinically. The instant blood-mediated inflammatory reaction (IBMIR) is a plausible underlying cause for this cell loss. The present study was designed to evaluate the capacity of low molecular weight dextran sulfate (LMW-DS) to control these initial reactions from the innate immune system. Fresh and cryopreserved hepatocytes were tested in an in vitro whole-blood model using ABO-compatible blood. The ability to elicit IBMIR and the capacity of LMW-DS (100 μg/ml) to attenuate the degree of activation of the cascade systems were monitored. The effect was also compared to conventional anticoagulant therapy using unfractionated heparin (1 IU/ml). Both fresh and freeze–thawed hepatocytes elicited IBMIR to the same extent. LMW-DS reduced the platelet loss and maintained the cell counts at the same degree as unfractionated heparin, but controlled the coagulation and complement systems significantly more efficiently than heparin. LMW-DS also attenuated the IBMIR elicited by freeze–thawed cells. Therefore, LMW-DS inhibits the cascade systems and maintains the cell counts in blood triggered by both fresh and cryopreserved hepatocytes in direct contact with ABO-matched blood. LMW-DS at a previously used and clinically applicable concentration (100 μg/ml) inhibits IBMIR in vitro and is therefore a potential IBMIR inhibitor in hepatocyte transplantation.

Low molecular weight dextran sulfate prevents complement activation and delays hyperacute rejection in pig-to-human xenotransplantation models

2001 ◽  
Vol 8 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Patrizia Fiorante ◽  
Yara Banz ◽  
Paul J. Mohacsi ◽  
Andreas Kappeler ◽  
Walter A. Wuillemin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Complement Activation ◽  
Dextran Sulfate ◽  
Hyperacute Rejection ◽  
Low Molecular Weight ◽  
Human Xenotransplantation
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