CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis

2007 ◽  
Vol 44 (8) ◽  
pp. 1935-1943 ◽  
Author(s):  
Michael Mølhøj ◽  
Sandrine Crommer ◽  
Klaus Brischwein ◽  
Doris Rau ◽  
Mirnaalini Sriskandarajah ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Bispecific Antibody ◽  
Cell Lysis ◽  
Tumor Cell Lysis

A new format of bispecific antibody: highly efficient heterodimerization, expression and tumor cell lysis

2005 ◽  
Vol 296 (1-2) ◽  
pp. 95-101 ◽  
Author(s):  
Zhigang Xie ◽  
Ning Guo ◽  
Ming Yu ◽  
Meiru Hu ◽  
Beifen Shen
Keyword(s):  
Tumor Cell ◽  
Bispecific Antibody ◽  
Cell Lysis ◽  
Highly Efficient ◽  
Tumor Cell Lysis

Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody

2003 ◽  
Vol 105 (2) ◽  
pp. 241-248 ◽  
Author(s):  
Pauline Wimberger ◽  
Wei Xiang ◽  
Doris Mayr ◽  
Joachim Diebold ◽  
Torsten Dreier ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Lymphocytes ◽  
Tumor Cell ◽  
Bispecific Antibody ◽  
Cell Lysis ◽  
Autologous Tumor ◽  
Primary Ovarian Cancer ◽  
Tumor Cell Lysis

Trifunctional bispecific antibody-induced tumor cell lysis of squamous cell carcinomas of the upper aerodigestive tract

Head & Neck ◽  
2005 ◽  
Vol 27 (5) ◽  
pp. 376-382 ◽  
Author(s):  
Silke S. Gronau ◽  
Michael Schmitt ◽  
Bernard Thess ◽  
Peter Reinhardt ◽  
Markus Wiesneth ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Squamous Cell ◽  
Bispecific Antibody ◽  
Cell Lysis ◽  
Squamous Cell Carcinomas ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Tumor Cell Lysis

A CR2-Fc fusion protein enhances antibody-dependent mechanisms of tumor cell lysis

2007 ◽  
Vol 44 (1-3) ◽  
pp. 187
Author(s):  
Masaki Imai ◽  
Rieko Ohta ◽  
Juan C. Varela ◽  
Hongbin Song ◽  
Stephen Tomlinson
Keyword(s):  
Fusion Protein ◽  
Tumor Cell ◽  
Cell Lysis ◽  
Fc Fusion Protein ◽  
Tumor Cell Lysis

scholarly journals A survivin specific T-cell clone from a breast cancer patient displays universal tumor cell lysis

2008 ◽  
Vol 7 (12) ◽  
pp. 1885-1887 ◽  
Author(s):  
Rikke Bæk Sørensen ◽  
Inge Marie Svane ◽  
Per thor Straten ◽  
Mads Hald Andersen
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cancer Patient ◽  
Tumor Cell ◽  
Breast Cancer Patient ◽  
Cell Clone ◽  
Cell Lysis ◽  
T Cell Clone ◽  
Tumor Cell Lysis

scholarly journals NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily

1999 ◽  
Vol 189 (5) ◽  
pp. 787-796 ◽  
Author(s):  
Claudia Cantoni ◽  
Cristina Bottino ◽  
Massimo Vitale ◽  
Anna Pessino ◽  
Raffaella Augugliaro ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Cell Lysis ◽  
Surface Expression ◽  
Immunoglobulin Superfamily ◽  
Surface Receptors ◽  
A Minor ◽  
Tumor Cell Lysis

Surface receptors involved in natural killer (NK) cell triggering during the process of tumor cell lysis have recently been identified. Of these receptors, NKp44 is selectively expressed by IL-2– activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Here we describe the molecular cloning of NKp44. Analysis of the cloned cDNA indicated that NKp44 is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor–associated polypeptide (KARAP)/DAP12. These molecules were found to be crucial for the surface expression of NKp44. In agreement with data of NKp44 surface expression, the NKp44 transcripts were strictly confined to activated NK cells and to a minor subset of TCR-γ/δ+ T lymphocytes. Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6.

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