Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells

2007 ◽  
Vol 44 (8) ◽  
pp. 2107-2114 ◽  
Author(s):  
Markus Schwab ◽  
Veerle Reynders ◽  
Yogesh Shastri ◽  
Stefan Loitsch ◽  
Jürgen Stein ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors

scholarly journals Involvement of Histone Methylation and Phosphorylation in Regulation of Transcription by Thyroid Hormone Receptor

2002 ◽  
Vol 22 (16) ◽  
pp. 5688-5697 ◽  
Author(s):  
Jiwen Li ◽  
Qiushi Lin ◽  
Ho-Geun Yoon ◽  
Zhi-Qing Huang ◽  
Brian D. Strahl ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Histone Acetylation ◽  
Histone Methylation ◽  
Hormone Receptor ◽  
Transcriptional Control ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Nuclear Hormone Receptors ◽  
Regulation Of Transcription

ABSTRACT Previous studies have established an important role of histone acetylation in transcriptional control by nuclear hormone receptors. With chromatin immunoprecipitation assays, we have now investigated whether histone methylation and phosphorylation are also involved in transcriptional regulation by thyroid hormone receptor (TR). We found that repression by unliganded TR is associated with a substantial increase in methylation of H3 lysine 9 (H3-K9) and a decrease in methylation of H3 lysine 4 (H3-K4), methylation of H3 arginine 17 (H3-R17), and a dual modification of phosphorylation of H3 serine 10 and acetylation of lysine 14 (pS10/acK14). On the other hand, transcriptional activation by liganded TR is coupled with a substantial decrease in both H3-K4 and H3-K9 methylation and a robust increase in H3-R17 methylation and the dual modification of pS10/acK14. Trichostatin A treatment results in not only histone hyperacetylation but also an increase in methylation of H3-K4, increase in dual modification of pS10/acK14, and reduction in methylation of H3-K9, revealing an extensive interplay between histone acetylation, methylation, and phosphorylation. In an effort to understand the underlying mechanism for an increase in H3-K9 methylation during repression by unliganded TR, we demonstrated that TR interacts in vitro with an H3-K9-specific histone methyltransferase (HMT), SUV39H1. Functional analysis indicates that SUV39H1 can facilitate repression by unliganded TR and in so doing requires its HMT activity. Together, our data uncover a novel role of H3-K9 methylation in repression by unliganded TR and provide strong evidence for the involvement of multiple distinct histone covalent modifications (acetylation, methylation, and phosphorylation) in transcriptional control by nuclear hormone receptors.

scholarly journals The role of nuclear hormone receptors in cutaneous wound repair

2014 ◽  
Vol 33 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Sandra Rieger ◽  
Hengguang Zhao ◽  
Paige Martin ◽  
Koichiro Abe ◽  
Thomas S. Lisse
Keyword(s):  
Wound Repair ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors ◽  
Cutaneous Wound

Gene repression by nuclear hormone receptors

2004 ◽  
Vol 40 ◽  
pp. 89-104 ◽  
Author(s):  
Udo Moehren ◽  
Maren Eckey ◽  
Aria Baniahmad
Keyword(s):  
Hormone Receptors ◽  
Chromatin Modification ◽  
Chromatin Accessibility ◽  
Nuclear Hormone Receptors ◽  
Comprehensive Overview ◽  
Cancer Proliferation ◽  
Response Elements ◽  
Breast And Prostate Cancer ◽  
Basal Transcription Factors

Repression by nuclear hormone receptors (NHRs) plays an important role in development, immune response and cellular function. We review mechanisms of how NHRs act as repressors of gene transcription either by direct contact with basal transcription factors or through recruitment of cofactors and enzymic activities that modulate chromatin accessibility. We describe also the role and biochemical mechanism of the cognate hormone that switches a NHR from a transcriptional silencer into an activator. This includes data from crystal structure, functional receptor domain analyses and the role of co-repressors in chromatin modification and remodelling. Furthermore, the comparison of negative response elements with classical response elements unravels the role of co-repressors in this context. We also describe the inhibition of the nuclear factor kappaB and Jun/Fos pathway by NHRs, as well as the molecular mechanism of anti-hormone therapies. Anti-hormones are commonly used in breast and prostate cancer therapy to inhibit cancer proliferation through repression of the oestrogen or androgen receptor, respectively. Here we provide a comprehensive overview of the various mechanism of NHR repression.

Nuclear Hormone Receptors and Adipogenesis

1998 ◽  
Vol 8 (2) ◽  
pp. 141-168 ◽  
Author(s):  
Jeffrey M. Gimble ◽  
Claudius E. Robinson ◽  
Stephen L. Clarke ◽  
Molly R. Hill
Keyword(s):  
Hormone Receptors ◽  
Nuclear Hormone Receptors

scholarly journals Towards designing globular antimicrobial peptide mimics: role of polar functional groups in biomimetic ternary antimicrobial polymers

Soft Matter ◽  
2021 ◽  
Author(s):  
Garima Rani ◽  
Kenichi Kuroda ◽  
Satyavani Vemparala
Keyword(s):  
Molecular Dynamics ◽  
Antimicrobial Peptide ◽  
Bacterial Membrane ◽  
Simulation Data ◽  
Antimicrobial Polymers ◽  
Polar Groups ◽  
Methacrylate Polymers ◽  
Dynamics Simulations ◽  
Polar Functional Groups

Using atomistic molecular dynamics simulations, we study the interaction of ternary methacrylate polymers, composed of charged cationic, hydrophobic and neutral polar groups, with model bacterial membrane. Our simulation data shows...

scholarly journals The Roles of DNA Demethylases in Triple-Negative Breast Cancer

2021 ◽  
Vol 14 (7) ◽  
pp. 628
Author(s):  
Shoghag Panjarian ◽  
Jean-Pierre J. Issa
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Tumor Suppressor Genes ◽  
Hormone Receptors ◽  
Triple Negative ◽  
Breast Cancers ◽  
Therapeutic Implications ◽  
High Propensity ◽  
Dna Methylation Profile

Triple-negative breast cancers (TNBCs) are very heterogenous, molecularly diverse, and are characterized by a high propensity to relapse or metastasize. Clinically, TNBC remains a diagnosis of exclusion by the lack of hormone receptors (Estrogen Receptor (ER) and Progesterone Receptor (PR)) as well as the absence of overexpression and/or amplification of HER2. DNA methylation plays an important role in breast cancer carcinogenesis and TNBCs have a distinct DNA methylation profile characterized by marked hypomethylation and lower gains of methylations compared to all other subtypes. DNA methylation is regulated by the balance of DNA methylases (DNMTs) and DNA demethylases (TETs). Here, we review the roles of TETs as context-dependent tumor-suppressor genes and/or oncogenes in solid tumors, and we discuss the current understandings of the oncogenic role of TET1 and its therapeutic implications in TNBCs.

877 ROLE OF STEROID HORMONE RECEPTORS ON FORMATION AND PROGRESSION OF BLADDER CARCINOMA

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Gholamreza Pourmand ◽  
Sepehr Salem ◽  
Abdolrasoul Mehrsai ◽  
Farid Kosari
Keyword(s):  
Bladder Carcinoma ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors
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