scholarly journals Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

2012 ◽  
Vol 48 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Anja Hoffmann ◽  
Annemarie H. Becker ◽  
Beate Zachmann-Brand ◽  
Elke Deuerling ◽  
Bernd Bukau ◽  
...  
Keyword(s):  
Trigger Factor ◽  
Concerted Action ◽  
Nascent Polypeptide ◽  
Polypeptide Folding

scholarly journals Alternate Recruitment of Signal Recognition Particle and Trigger Factor to the Signal Sequence of a Growing Nascent Polypeptide

2006 ◽  
Vol 281 (11) ◽  
pp. 7172-7179 ◽  
Author(s):  
Gottfried Eisner ◽  
Michael Moser ◽  
Ute Schäfer ◽  
Konstanze Beck ◽  
Matthias Müller
Keyword(s):  
Signal Sequence ◽  
Signal Recognition Particle ◽  
Trigger Factor ◽  
Signal Recognition ◽  
Nascent Polypeptide

scholarly journals The Crimes of the Powerful: Between Force and Consensus

2021 ◽  
Vol 10 (2) ◽  
pp. 51
Author(s):  
Vincenzo Ruggiero
Keyword(s):  
Concerted Action ◽  
Ability To Act ◽  
Legal Responses

Power entails the ability to act and overcome the obstacles erected by those who are subject to it. It also entails the capacity to make one’s crimes acceptable, while formulating criminal imputations against others. The crimes of the powerful, in this contribution, are examined through the lenses of a number of intertwined variables: coercion, legitimacy, violence, secrecy, consensus, and hegemony. Ostentation, imitation, and admiration are also considered as components of these types of crimes and the feelings they elicit. While the controversies surrounding legal responses to the crimes of the powerful are discussed, the efficacy of concerted action against them is optimistically invoked.

scholarly journals Guillain-Barré syndrome triggered by surgery in a Chinese population: a multicenter retrospective study

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qiaoyu Gong ◽  
Shuping Liu ◽  
Yin Liu ◽  
Jiajia Yao ◽  
Xiujuan Fu ◽  
...  
Keyword(s):  
Clinical Features ◽  
Orthopedic Surgery ◽  
Southern China ◽  
Axonal Neuropathy ◽  
Trigger Factor ◽  
Guillain Barre Syndrome ◽  
Initial Symptoms ◽  
Guillain Barré Syndrome ◽  
Potential Trigger ◽  
Guillain Barré

Abstract Background Surgery is a potential trigger of Guillain-Barré syndrome (GBS), a disorder which leads to an autoimmune-mediated attack of peripheral nerves. The present study was designed to explore clinical features of post-surgical GBS compared with those of general GBS in order to provide better clinical advice to patients undergoing surgery. Methods The medical records of GBS patients who were seen at 31 tertiary hospitals in southern China between January 1, 2013 and September 30, 2016 were retrospectively analyzed. Post-surgical GBS was defined as symptoms of GBS within 6 weeks after surgery. Clinical features of post-surgical GBS are described and are compared with general GBS. Results Among the 1001 GBS patient cases examined in this study, 45 (4.5%) patient cases exhibited symptoms of GBS within 6 weeks of undergoing surgery. Within this group, 36 (80.0%) patients developed initial symptoms of limb weakness. The average interval between surgery and symptom onset was 13.31 days. The most common type of surgery which triggered GBS was orthopedic surgery, followed by neurological surgery. Compared to general GBS, post-surgical GBS was characterized by a higher proportion of severe patients (Hughes functional grading scale (HFGS) score ≥ 3) upon admission and at nadir, higher HFGS scores at discharge, and longer hospital stays. Post-surgical GBS patients also had a significantly higher frequency of the acute motor axonal neuropathy subtype (37.9 vs. 14.2, respectively; P = 0.001). Conclusion Surgery is probably a potential trigger factor for GBS, especially orthopedic surgery. Infections secondary to surgery may play a role. The possibility of preceding (post-operative) infections was not excluded in this study. Clinical presentation of post-surgical GBS is characterized by a more severe course and poorer prognosis, and should be closely monitored. Trial registration chicTR-RRc-17,014,152.

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