scholarly journals The Crimes of the Powerful: Between Force and Consensus

2021 ◽  
Vol 10 (2) ◽  
pp. 51
Author(s):  
Vincenzo Ruggiero
Keyword(s):  
Concerted Action ◽  
Ability To Act ◽  
Legal Responses

Power entails the ability to act and overcome the obstacles erected by those who are subject to it. It also entails the capacity to make one’s crimes acceptable, while formulating criminal imputations against others. The crimes of the powerful, in this contribution, are examined through the lenses of a number of intertwined variables: coercion, legitimacy, violence, secrecy, consensus, and hegemony. Ostentation, imitation, and admiration are also considered as components of these types of crimes and the feelings they elicit. While the controversies surrounding legal responses to the crimes of the powerful are discussed, the efficacy of concerted action against them is optimistically invoked.

Characteristics Of The Structure Formation Of Gypsum Binder Modified With Zinc Hydrosilicates

2020 ◽  
pp. 40-46
Keyword(s):  
Synergistic Effect ◽  
Physicochemical Properties ◽  
Structure Formation ◽  
Silicic Acid ◽  
Chemical Properties ◽  
Crystal Formation ◽  
Ability To Act ◽  
Chemical Factors ◽  
Sorption Characteristics

The authors' methodic for assessing the role of chemical and physic-chemical factors during the structure formation of gypsum stone is presented in the article. The methodic is also makes it possible to reveal the synergistic effect and to determine the ranges of variation of controls factors that ensure maximum values of such effect. The effect of a micro-sized modifier based on zinc hydro-silicates on the structure formation of building gypsum is analyzed and corresponding dependencies are found. It is shown that effects of influence of modifier on the properties of gypsum compositions are determined by chemical properties of modifier. Among the mentioned properties are sorption characteristics (which depend on the amount of silicic acid and its state) and physicochemical properties - the ability to act as a substrate during crystal formation. The proposed method can also be extended to other binding substances and materials. This article contributes to the understanding of the processes that occur during the structure formation of composites, which will make it possible to control the structure formation in the future, obtaining materials with a given set of properties.

Shakespeare's Representation of Weather, Climate and Environment

2019 ◽  
Author(s):  
Sophie Chiari
Keyword(s):  
Early Modern ◽  
Free Will ◽  
Religious Beliefs ◽  
Early Modern England ◽  
Literary Texts ◽  
Romeo And Juliet ◽  
Midsummer Night's Dream ◽  
The Tempest ◽  
As You Like It ◽  
Ability To Act

While ecocritical approaches to literary texts receive more and more attention, climate-related issues remain fairly neglected, particularly in the field of Shakespeare studies. This monograph explores the importance of weather and changing skies in early modern England while acknowledging the fact that traditional representations and religious beliefs still fashioned people’s relations to meteorological phenomena. At the same time, a growing number of literati stood against determinism and defended free will, thereby insisting on man’s ability to act upon celestial forces. Yet, in doing so, they began to give precedence to a counter-intuitive approach to Nature. Sophie Chiari argues that Shakespeare reconciles the scholarly views of his time with more popular ideas rooted in superstition and that he promotes a sensitive, pragmatic understanding of climatic events. She pays particular attention to A Midsummer Night’s Dream, Romeo and Juliet, As You Like It, Othello, King Lear, Anthony and Cleopatra, and The Tempest. Taking into account the influence of classical thought, each of the book’s seven chapters emphasises specific issues (e.g. cataclysmic disorders, the dog days’ influence, freezing temperatures, threatening storms) and considers the way climatic events were presented on stage and how they came to shape the production and reception of Shakespeare’s drama.

Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment

2020 ◽  
Vol 20 (6) ◽  
pp. 444-465 ◽  
Author(s):  
Jessica Ceramella ◽  
Domenico Iacopetta ◽  
Alexia Barbarossa ◽  
Anna Caruso ◽  
Fedora Grande ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Drug Targets ◽  
Mechanisms Of Action ◽  
Biological Pathways ◽  
G Protein Coupled Receptors ◽  
Ability To Act ◽  
Different Types ◽  
Activity Of Enzymes ◽  
Intercalating Agents ◽  
G Protein Coupled

Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human tumorigenesis and cancer progression, PKs are ideal targets for the design and development of effective and low toxic chemotherapeutics and represent the second group of drug targets after G-protein-coupled receptors. Nowadays, several compounds have been claimed to be PKs inhibitors, and some of them, such as imatinib, erlotinib and gefitinib, have already been approved for clinical use, whereas more than 30 others are in various phases of clinical trials. Among them, some natural or synthetic carbazole-based molecules represent promising PKs inhibitors due to their capability to interfere with PK activity by different mechanisms of action including the ability to act as DNA intercalating agents, interfere with the activity of enzymes involved in DNA duplication, such as topoisomerases and telomerases, and inhibit other proteins such as cyclindependent kinases or antagonize estrogen receptors. Thus, carbazoles can be considered a promising this class of compounds to be adopted in targeted therapy of different types of cancer.

Pathogenesis of Age-related Cataract: a systematic review of proteomic studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Christina Karakosta ◽  
Argyrios Tzamalis ◽  
Michalis Aivaliotis ◽  
Ioannis Tsinopoulos
Keyword(s):  
Systematic Review ◽  
Oxidant Stress ◽  
Critical Role ◽  
Human Lens ◽  
Nuclear Cataract ◽  
Cataract Formation ◽  
Post Translational Modification ◽  
Ability To Act ◽  
Age Related

Background/Objective:: The aim of this systematic review is to identify all the available data on human lens proteomics with a critical role to age-related cataract formation in order to elucidate the physiopathology of the aging lens. Materials and Methods:: We searched on Medline and Cochrane databases. The search generated 328 manuscripts. We included nine original proteomic studies that investigated human cataractous lenses. Results:: Deamidation was the major age-related post-translational modification. There was a significant increase in the amount of αA-crystallin D-isoAsp58 present at all ages, while an increase in the extent of Trp oxidation was apparent in cataract lenses when compared to aged normal lenses. During aging, enzymes with oxidized cysteine at critical sites included GAPDH, glutathione synthase, aldehyde dehydrogenase, sorbitol dehydrogenase, and PARK7. Conclusion:: D-isoAsp in αA crystallin could be associated with the development of age-related cataract in human, by contributing to the denaturation of a crystallin, and decreasing its ability to act as a chaperone. Oxidation of Trp may be associated with nuclear cataract formation in human, while the role of oxidant stress in age-related cataract formation is dominant.

Kronisk sygdom som biografisk hændelse - et studie af bypassopererede kronisk hjertesyge menneskers biografiske arbejde

1970 ◽  
Vol 12 (3) ◽  
pp. 85-98
Author(s):  
Rasmus Antoft
Keyword(s):  
Heart Disease ◽  
Everyday Life ◽  
Social Relations ◽  
Social Action ◽  
Chronically Ill ◽  
Role Playing ◽  
Self Presentation ◽  
Self Identity ◽  
Chronic Heart Disease ◽  
Ability To Act

Chronic illness as biographical occurrence – a study on bypass operated individuals and their biographical work. The primary focus of this article is on bypass operated chronically ill peoples attempt to re-establish their biographical work, their everyday life. The everyday life experiences based on routines and obviousness are subjugated by the chronicle illness influence on the life narrative, its future character and the way in which it affects the shaping of identity, the biographical work. Two different themes are central in individual’s narratives about their everyday life with a chronic heart disease. These themes concern their self-presentation in inter-action with others and their anxiety directed at the future life with the illness, with the anxiety of death. This study shows that every bypass operated and chronically ill participant have experienced difficulties in reshaping their normal biographical work. Their ability to regain social action as part of the biographical work and their shaping of self-identity, has been altered significantly. In various situations this leads to potential stigmatisation, but also to a lack of acceptance in the role-playing of a chronic ill, be that in interaction with strangers or intimate social relations. This causes identity dilemmas, paradoxes in self-presentation and, as a consequence, self-deception in everyday life. The existential problem of anxiety and its subjugating character in the lifeplaning and biographical work is to be explained by the risk of reoccurrence of the heart disease, and by the latency of the possible terminal nature of the disease. The nature of the illness ruptures routines and the predictability of everyday life, thus manifesting itself in key situations of everyday life. In addition to this, the anxiety generates a lack of ability to act actively, that is, the individuals ability actively shape its lifeplaning and its biographical work.

Cerium oxide nanomaterial with dual antioxidative scavenging potential: Synthesis and characterization

2021 ◽  
pp. 088532822110134
Author(s):  
Sushant Singh ◽  
Udit Kumar ◽  
David Gittess ◽  
Tamil S Sakthivel ◽  
Balaashwin Babu ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Biological Systems ◽  
Mixed Valence ◽  
Stable Solution ◽  
Ability To Act ◽  
Valence States ◽  
Transmission Electron ◽  
Efficient Reduction ◽  
Rich Media

Many studies have linked reactive oxygen species (ROS) to various diseases. Biomedical research has therefore sought a way to control and regulate ROS produced in biological systems. In recent years, cerium oxide nanoparticles (nanoceria, CNPs) have been pursued due to their ability to act as regenerative ROS scavengers. In particular, they are shown to have either superoxide dismutase (SOD) or catalase mimetic (CAT) potential depending on the ratio of Ce3+/Ce4+ valence states. Moreover, it has been demonstrated that SOD mimetic activity can be diminished by the presence of phosphate, which can be a problem given that many biological systems operate in a phosphate-rich environment. Herein, we report a CNP formulation with both SOD and catalase mimetic activity that is preserved in a phosphate-rich media. Characterization demonstrated a highly dispersed, stable solution of uniform-sized, spherical-elliptical shaped CNP of 12 ± 2 nm, as determined through dynamic light scattering, zeta potential, and transmission electron microscopy. Mixed valence states of Ce ions were observed via UV/Visible spectroscopy and XPS (Ce3+/Ce4+ > 1) (Ce3+∼ 62%). X-ray diffraction and XPS confirmed the presence of oxygen-deficient cerium oxide (CeO2-x) particles. Finally, the CNP demonstrated very good biocompatibility and efficient reduction of hydrogen peroxide under in-vitro conditions.

scholarly journals Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1478
Author(s):  
Marcelo D. Catarino ◽  
Sónia J. Amarante ◽  
Nuno Mateus ◽  
Artur M. S. Silva ◽  
Susana M. Cardoso
Keyword(s):  
Oxidative Stress ◽  
Physical Inactivity ◽  
Dietary Habits ◽  
Vegetable Intake ◽  
Fruit And Vegetable Intake ◽  
Bioactive Properties ◽  
Ability To Act ◽  
Pharmaceutical Industries ◽  
Biochemical Mechanisms ◽  
Cancer Network

According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress–inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.

scholarly journals Polaritonic XY-Ising machine

Nanophotonics ◽  
2020 ◽  
Vol 9 (13) ◽  
pp. 4127-4138 ◽  
Author(s):  
Kirill P. Kalinin ◽  
Alberto Amo ◽  
Jacqueline Bloch ◽  
Natalia G. Berloff
Keyword(s):  
Dissipative Systems ◽  
Phase Information ◽  
Physical Origin ◽  
Continuous Spin ◽  
Network Nodes ◽  
Computing Platform ◽  
Ability To Act ◽  
Spin Hamiltonians ◽  
Long Range Interactions ◽  
Accuracy And Stability

AbstractGain-dissipative systems of various physical origin have recently shown the ability to act as analogue minimisers of hard combinatorial optimisation problems. Whether or not these proposals will lead to any advantage in performance over the classical computations depends on the ability to establish controllable couplings for sufficiently dense short- and long-range interactions between the spins. Here, we propose a polaritonic XY-Ising machine based on a network of geometrically isolated polariton condensates capable of minimising discrete and continuous spin Hamiltonians. We elucidate the performance of the proposed computing platform for two types of couplings: relative and absolute. The interactions between the network nodes might be controlled by redirecting the emission between the condensates or by sending the phase information between nodes using resonant excitation. We discuss the conditions under which the proposed machine leads to a pure polariton simulator with pre-programmed couplings or results in a hybrid classical polariton simulator. We argue that the proposed architecture for the remote coupling control offers an improvement over geometrically coupled condensates in both accuracy and stability as well as increases versatility, range, and connectivity of spin Hamiltonians that can be simulated with polariton networks.

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