scholarly journals The RanBP2/RanGAP1∗SUMO1/Ubc9 Complex Is a Multisubunit SUMO E3 Ligase

2012 ◽  
Vol 46 (3) ◽  
pp. 287-298 ◽  
Author(s):  
Andreas Werner ◽  
Annette Flotho ◽  
Frauke Melchior
Keyword(s):  
E3 Ligase ◽  
Sumo E3 Ligase

scholarly journals Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

Cancer Cell ◽  
2014 ◽  
Vol 25 (4) ◽  
pp. 547-548
Author(s):  
Jie Li ◽  
Ying Xu ◽  
Xi-Dai Long ◽  
Wei Wang ◽  
Hui-Ke Jiao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
E3 Ligase ◽  
Sumo E3 Ligase

scholarly journals The SUMO E3 Ligase MdSIZ1 Targets MdbHLH104 to Regulate Plasma Membrane H+-ATPase Activity and Iron Homeostasis

2018 ◽  
Vol 179 (1) ◽  
pp. 88-106 ◽  
Author(s):  
Li-Jie Zhou ◽  
Chun-Ling Zhang ◽  
Rui-Fen Zhang ◽  
Gui-Luan Wang ◽  
Yuan-Yuan Li ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Atpase Activity ◽  
Iron Homeostasis ◽  
E3 Ligase ◽  
Sumo E3 Ligase

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

2004 ◽  
Vol 11 (10) ◽  
pp. 984-991 ◽  
Author(s):  
Andrea Pichler ◽  
Puck Knipscheer ◽  
Hisato Saitoh ◽  
Titia K Sixma ◽  
Frauke Melchior
Keyword(s):  
E3 Ligase ◽  
Ring Type ◽  
Sumo E3 Ligase

scholarly journals TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1

2014 ◽  
Vol 289 (36) ◽  
pp. 25067-25078 ◽  
Author(s):  
Yoshiho Ikeuchi ◽  
Shorafidinkhuja Dadakhujaev ◽  
Amrita S. Chandhoke ◽  
Mai Anh Huynh ◽  
Anna Oldenborg ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
E3 Ligase ◽  
Transcriptional Regulator ◽  
Mesenchymal Transition ◽  
Sumo E3 Ligase

scholarly journals The Function of LPR1 is Controlled by an Element in the Promoter and is Independent of SUMO E3 Ligase SIZ1 in Response to Low Pi Stress in Arabidopsis thaliana

2010 ◽  
Vol 51 (3) ◽  
pp. 380-394 ◽  
Author(s):  
Xuemin Wang ◽  
Guankui Du ◽  
Xuming Wang ◽  
Yijun Meng ◽  
Yiyi Li ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
E3 Ligase ◽  
Low Pi Stress ◽  
Sumo E3 Ligase ◽  
Pi Stress

scholarly journals TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification

2015 ◽  
Vol 35 (16) ◽  
pp. 2851-2863 ◽  
Author(s):  
Shu Hui Neo ◽  
Yoko Itahana ◽  
Jennifer Alagu ◽  
Mayumi Kitagawa ◽  
Alvin Kunyao Guo ◽  
...  
Keyword(s):  
Tumor Suppressors ◽  
Physiological Function ◽  
E3 Ligase ◽  
Genomic Stability ◽  
Centrosome Amplification ◽  
Genome Integrity ◽  
Centrosome Duplication ◽  
Oncogenic Ras ◽  
Sumo Ligase ◽  
Sumo E3 Ligase

The tumor suppressor ARF enhances the SUMOylation of target proteins; however, the physiological function of ARF-mediated SUMOylation has been unclear due to the lack of a known, associated E3 SUMO ligase. Here we uncover TRIM28/KAP1 as a novel ARF-binding protein and SUMO E3 ligase for NPM1/B23. ARF and TRIM28 cooperate to SUMOylate NPM1, a nucleolar protein that regulates centrosome duplication and genomic stability. ARF-mediated SUMOylation of NPM1 was attenuated by TRIM28 depletion and enhanced by TRIM28 overexpression. Coexpression of ARF and TRIM28 promoted NPM1 centrosomal localization by enhancing its SUMOylation and suppressed centrosome amplification; these functions required the E3 ligase activity of TRIM28. Conversely, depletion of ARF or TRIM28 increased centrosome amplification. ARF also counteracted oncogenic Ras-induced centrosome amplification. Centrosome amplification is often induced by oncogenic insults, leading to genomic instability. However, the mechanisms employed by tumor suppressors to protect the genome are poorly understood. Our findings suggest a novel role for ARF in maintaining genome integrity by facilitating TRIM28-mediated SUMOylation of NPM1, thus preventing centrosome amplification.

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