Expression of Drosophila rhodopsins during photoreceptor cell differentiation: Insights into R7 and R8 cell subtype commitment

2006 ◽  
Vol 6 (7) ◽  
pp. 687-694 ◽  
Author(s):  
James B. Earl ◽  
Steven G. Britt
Keyword(s):  
Cell Differentiation ◽  
Photoreceptor Cell ◽  
Cell Subtype

scholarly journals The Differences in the Expressions of Visual Pigments and Transducin in Photoreceptor Cell Differentiation.

1996 ◽  
Vol 178 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Hiroshi Ohguro ◽  
Kouichi Kitamura ◽  
Kenji Konari ◽  
Hitoshi Sohma ◽  
Yoshitaka Fukada ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Photoreceptor Cell ◽  
Visual Pigments

scholarly journals Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation

2016 ◽  
Vol 45 (3) ◽  
pp. 1233-1254 ◽  
Author(s):  
Nicole Vo ◽  
Dang Ngoc Anh Suong ◽  
Natsuki Yoshino ◽  
Hideki Yoshida ◽  
Sue Cotterill ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Dna Replication ◽  
Photoreceptor Cell ◽  
Genome Maintenance

scholarly journals Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack

Cell ◽  
1997 ◽  
Vol 90 (3) ◽  
pp. 469-478 ◽  
Author(s):  
Songhui Li ◽  
Ying Li ◽  
Richard W Carthew ◽  
Zhi-Chun Lai
Keyword(s):  
Cell Differentiation ◽  
Photoreceptor Cell ◽  
Transcriptional Repressor

scholarly journals Drosophila R8 photoreceptor cell subtype specification requires hibris

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240451
Author(s):  
Hong Tan ◽  
Ruth E. Fulton ◽  
Wen-Hai Chou ◽  
Denise A. Birkholz ◽  
Meridee P. Mannino ◽  
...  
Keyword(s):  
Photoreceptor Cell ◽  
Cell Subtype

scholarly journals Drosophila R8 photoreceptor cell subtype specification requires Notch and hibris

2018 ◽  
Author(s):  
Hong Tan ◽  
Ruth E. Fulton ◽  
Wen-Hai Chou ◽  
Denise A. Birkholz ◽  
Meridee P. Mannino ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Cell Differentiation ◽  
Photoreceptor Cell ◽  
Compound Eye ◽  
Visual Pigments ◽  
Exact Nature ◽  
Diverse Range ◽  
Developmental Program ◽  
Color Sensitivity ◽  
Different Types

AbstractCell differentiation and cell fate determination in sensory systems are essential for stimulus discrimination and coding of environmental stimuli. Color vision is based on the differential color sensitivity of retinal photoreceptors, however the developmental programs that control photoreceptor cell differentiation and specify color sensitivity are poorly understood. In Drosophila melanogaster, there is evidence that the color sensitivity of different photoreceptors in the compound eye is regulated by inductive signals between cells, but the exact nature of these signals and how they are propagated remains unknown. We conducted a genetic screen to identify additional regulators of this process and identified a novel mutation in the hibris gene. hibris encodes an irre cell recognition module protein (IRM). These immunoglobulin super family cell adhesion molecules include human neph and nephrin (NPHS1). hibris is expressed dynamically in the developing Drosophila melanogaster eye and loss-of-function mutations give rise to a diverse range of mutant phenotypes including disruption of the specification of R8 photoreceptors cell diversity. The specification of blue or green sensitivity in R8 cells is also dependent upon Notch signaling. We demonstrate that hibris is required within the retina, non-cell autonomously for these effects, suggesting an additional layer of complexity in the signaling process that produces paired expression of opsin genes in adjacent R7 and R8 photoreceptor cells.Author SummaryAs humans, our ability to distinguish different colors is dependent upon the presence of three different types of cone cell neurons in the retina of the eye. The cone cells express blue, green or red absorbing visual pigments that detect and discriminate between these colors. The principle of color discrimination by neurons “tuned” to different colors is an evolutionarily conserved specialization that occurs in many different animals. This specialization requires 1) visual pigments that detect different colors and 2) a developmental program that regulates the expression of these pigments in different types of cells. In this study we discovered that the fruit fly (Drosophila melanogaster) gene hibris is required for the developmental program that produces blue sensitive neurons in the fly retina. When we over-expressed hibris throughout the developing retina, extra blue sensitive cells were produced. These results demonstrate that if there is not enough hibris, too few blue sensitive cells form, but if there is too much hibris, too many blue sensitive cells form. Finally, we discovered that the hibris gene does not act in color sensitive neurons of the retina themselves. This surprising discovery suggests that hibris may influence development of the retina in a completely new and different way.

scholarly journals Common Transcriptional Mechanisms for Visual Photoreceptor Cell Differentiation among Pancrustaceans

PLoS Genetics ◽  
2014 ◽  
Vol 10 (7) ◽  
pp. e1004484 ◽  
Author(s):  
Simpla Mahato ◽  
Shinichi Morita ◽  
Abraham E. Tucker ◽  
Xulong Liang ◽  
Magdalena Jackowska ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Photoreceptor Cell

scholarly journals SOCS3 is required to temporally fine-tune photoreceptor cell differentiation

2007 ◽  
Vol 303 (2) ◽  
pp. 591-600 ◽  
Author(s):  
Yoko Ozawa ◽  
Keiko Nakao ◽  
Takuya Shimazaki ◽  
Shigeto Shimmura ◽  
Toshihide Kurihara ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Photoreceptor Cell ◽  
Fine Tune
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