scholarly journals Development of iPSC-induced Neural Crest Cells and Enteric Neural Crest Stem Cells in the Gut Following Transplantation

2017 ◽  
Vol 145 ◽  
pp. S168
Author(s):  
Allan Jo Weng Lui ◽  
Lihua Bao ◽  
Yuzhe Niu ◽  
Wood Yee Chan
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Neural Crest Stem Cells

Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling

Development ◽  
2001 ◽  
Vol 128 (20) ◽  
pp. 3949-3961 ◽  
Author(s):  
Christian Paratore ◽  
Derk E. Goerich ◽  
Ueli Suter ◽  
Michael Wegner ◽  
Lukas Sommer
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Neural Crest ◽  
Hirschsprung Disease ◽  
Neural Crest Cells ◽  
Fine Tuning ◽  
Enteric Neurons ◽  
Dependent Manner ◽  
Neural Crest Stem Cells ◽  
Glial Fate

The transcription factor Sox10 is required for proper development of various neural crest-derived cell types. Several lineages including melanocytes, autonomic and enteric neurons, and all subtypes of peripheral glia are missing in mice homozygous for Sox10 mutations. Moreover, haploinsufficiency of Sox10 results in neural crest defects that cause Waardenburg/Hirschsprung disease in humans. We provide evidence that the cellular basis to these phenotypes is likely to be a requirement for Sox10 by neural crest stem cells before lineage segregation. Cell death is increased in undifferentiated, postmigratory neural crest cells that lack Sox10, suggesting a role of Sox10 in the survival of neural crest cells. This function is mediated by neuregulin, which acts as a survival signal for postmigratory neural crest cells in a Sox10-dependent manner. Furthermore, Sox10 is required for glial fate acquisition, as the surviving mutant neural crest cells are unable to adopt a glial fate when challenged with different gliogenic conditions. In Sox10 heterozygous mutant neural crest cells, survival appears to be normal, while fate specifications are drastically affected. Thereby, the fate chosen by a mutant neural crest cell is context dependent. Our data indicate that combinatorial signaling by Sox10, extracellular factors such as neuregulin 1, and local cell-cell interactions is involved in fine-tuning lineage decisions by neural crest stem cells. Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease.

scholarly journals Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness

Neuron ◽  
2002 ◽  
Vol 35 (4) ◽  
pp. 657-669 ◽  
Author(s):  
Genevieve M. Kruger ◽  
Jack T. Mosher ◽  
Suzanne Bixby ◽  
Nancy Joseph ◽  
Toshihide Iwashita ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Self Renewal ◽  
Neural Crest Stem Cells ◽  
Neuronal Subtype

scholarly journals Human iPSC-derived Neural Crest Stem Cells can produce EPO and induce erythropoiesis in anemic mice

2021 ◽  
pp. 102476
Author(s):  
Valerio Brizi ◽  
Sara Buttò ◽  
Domenico Cerullo ◽  
Angelo Michele Lavecchia ◽  
Raquel Rodrigues-Diez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Human Ipsc

Chicken dapper genes are versatile markers for mesodermal tissues, embryonic muscle stem cells, neural crest cells, and neurogenic placodes

2009 ◽  
Vol 238 (5) ◽  
pp. 1166-1178 ◽  
Author(s):  
Lúcia Elvira Alvares ◽  
Farrah Leigh Winterbottom ◽  
Débora Rodrigues Sobreira ◽  
José Xavier-Neto ◽  
Frank Richard Schubert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Muscle Stem Cells ◽  
Embryonic Muscle

scholarly journals Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

2015 ◽  
Vol 2 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Atsushi Tomokiyo ◽  
Kim Hynes ◽  
Stan Gronthos ◽  
Naohisa Wada ◽  
P. Mark Bartold
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Periodontal Regeneration ◽  
Neural Crest Stem Cells
Sign in / Sign up

Export Citation Format

Share Document