scholarly journals Asymmetric localization of Dlc1 defines trunk neural crest polarity for directional delamination and migration

2017 ◽  
Vol 145 ◽  
pp. S65
Author(s):  
Martin Cheung ◽  
Jessica Aijia Liu ◽  
Yanxia Rao ◽  
May Pui Lai Cheung ◽  
Man-Ning Hui ◽  
...  
Keyword(s):  
Neural Crest ◽  
Trunk Neural Crest ◽  
And Migration

Draxin inhibits chick trunk neural crest delamination and migration by increasing cell adhesion

2021 ◽  
Author(s):  
Juan Du ◽  
Sanbing Zhang ◽  
Jiqian Zhao ◽  
Sha Li ◽  
Wenyong Chen ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Neural Crest ◽  
Trunk Neural Crest ◽  
And Migration

scholarly journals Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jessica Aijia Liu ◽  
Yanxia Rao ◽  
May Pui Lai Cheung ◽  
Man-Ning Hui ◽  
Ming-Hoi Wu ◽  
...  
Keyword(s):  
Neural Crest ◽  
Trunk Neural Crest ◽  
And Migration

scholarly journals Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation

2016 ◽  
Vol 215 (5) ◽  
pp. 735-747 ◽  
Author(s):  
Andrew T. Schiffmacher ◽  
Vivien Xie ◽  
Lisa A. Taneyhill
Keyword(s):  
Neural Crest ◽  
Epithelial To Mesenchymal Transition ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Mesenchymal Transition ◽  
Effector Genes ◽  
A Disintegrin And Metalloproteinase ◽  
And Migration ◽  
Cranial Neural Crest Cells

During epithelial-to-mesenchymal transitions (EMTs), cells disassemble cadherin-based junctions to segregate from the epithelia. Chick premigratory cranial neural crest cells reduce Cadherin-6B (Cad6B) levels through several mechanisms, including proteolysis, to permit their EMT and migration. Serial processing of Cad6B by a disintegrin and metalloproteinase (ADAM) proteins and γ-secretase generates intracellular C-terminal fragments (CTF2s) that could acquire additional functions. Here we report that Cad6B CTF2 possesses a novel pro-EMT role by up-regulating EMT effector genes in vivo. After proteolysis, CTF2 remains associated with β-catenin, which stabilizes and redistributes both proteins to the cytosol and nucleus, leading to up-regulation of β-catenin, CyclinD1, Snail2, and Snail2 promoter-based GFP expression in vivo. A CTF2 β-catenin–binding mutant, however, fails to alter gene expression, indicating that CTF2 modulates β-catenin–responsive EMT effector genes. Notably, CTF2 association with the endogenous Snail2 promoter in the neural crest is β-catenin dependent. Collectively, our data reveal how Cad6B proteolysis orchestrates multiple pro-EMT regulatory inputs, including CTF2-mediated up-regulation of the Cad6B repressor Snail2, to ensure proper cranial neural crest EMT.

scholarly journals Molecular and Cellular Features of Murine Craniofacial and Trunk Neural Crest Cells as Stem Cell-Like Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84072 ◽  
Author(s):  
Kunie Hagiwara ◽  
Takeshi Obayashi ◽  
Nobuyuki Sakayori ◽  
Emiko Yamanishi ◽  
Ryuhei Hayashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Trunk Neural Crest

scholarly journals Characterization of late emerging trunk neural crest cells in the turtle Trachemys scripta

2010 ◽  
Vol 344 (1) ◽  
pp. 531
Author(s):  
Judith A. Cebra-Thomas ◽  
James Robinson ◽  
Melinda Yin ◽  
James McCarthy ◽  
Sonal Shah ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Trachemys Scripta ◽  
Trunk Neural Crest

scholarly journals 03-P132 Xenopus HMGA2 is required for neural crest cell survival and migration

2009 ◽  
Vol 126 ◽  
pp. S106
Author(s):  
Simone Macrí ◽  
Marco Onorati ◽  
Guidalberto Manfioletti ◽  
Robert Vignali
Keyword(s):  
Neural Crest ◽  
Cell Survival ◽  
Neural Crest Cell ◽  
And Migration ◽  
Crest Cell

The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling

2021 ◽  
Vol 480 ◽  
pp. 78-90
Author(s):  
Jennifer C. Kasemeier-Kulesa ◽  
Jennifer A. Spengler ◽  
Connor E. Muolo ◽  
Jason A. Morrison ◽  
Thomas E. Woolley ◽  
...  
Keyword(s):  
Neural Crest ◽  
Human Neuroblastoma ◽  
Trunk Neural Crest
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