scholarly journals 09-P048 Tbr2 promotes the growth of the cerebral cortex specifying Intermediate (Basal) Progenitor Cells

2009 ◽  
Vol 126 ◽  
pp. S164
Author(s):  
Alessandro Sessa ◽  
Chai-An Mao ◽  
Anna-Katerina Hadjantonakis ◽  
William H. Klein ◽  
Vania Broccoli
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Basal Progenitor

Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain

2018 ◽  
Vol 78 (7) ◽  
pp. 660-670 ◽  
Author(s):  
Alice Grison ◽  
Carine Gaiser ◽  
Andrea Bieder ◽  
Constanze Baranek ◽  
Suzana Atanasoski
Keyword(s):  
Progenitor Cells ◽  
Basal Progenitor

scholarly journals HIV induces airway basal progenitor cells to adopt an inflammatory phenotype

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nancy P. Y. Chung ◽  
K. M. Faisal Khan ◽  
Robert J. Kaner ◽  
Sarah L. O’Beirne ◽  
Ronald G. Crystal
Keyword(s):  
Progenitor Cells ◽  
Inflammatory Mediators ◽  
Lung Inflammation ◽  
Mapk Signaling ◽  
Gm Csf ◽  
Basal Progenitor ◽  
Inflammatory Phenotype ◽  
Mapk Signaling Pathways ◽  
Chronic Hiv Infection

AbstractDespite the introduction of anti-retroviral therapy, chronic HIV infection is associated with an increased incidence of other comorbidities such as COPD. Based on the knowledge that binding of HIV to human airway basal stem/progenitor cells (BC) induces a destructive phenotype by increased MMP-9 expression through MAPK signaling pathways, we hypothesized that HIV induces the BC to express inflammatory mediators that contribute to the pathogenesis of emphysema. Our data demonstrate that airway BC isolated from HAART-treated HIV+ nonsmokers spontaneously release inflammatory mediators IL-8, IL-1β, ICAM-1 and GM-CSF. Similarly, exposure of normal BC to HIV in vitro up-regulates expression of the same inflammatory mediators. These HIV-BC derived mediators induce migration of alveolar macrophages (AM) and neutrophils and stimulate AM proliferation. This HIV-induced inflammatory phenotype likely contributes to lung inflammation in HIV+ individuals and provides explanation for the increased incidence of COPD in HIV+ individuals.

Basal progenitor cells bridge the development, malignant cancers, and multiple diseases of esophagus

2017 ◽  
Vol 233 (5) ◽  
pp. 3855-3866
Author(s):  
Baoshun Lin ◽  
Fuan Xie ◽  
Zhangwu Xiao ◽  
Xiaoqian Hong ◽  
Liming Tian ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Basal Progenitor

Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling

2021 ◽  
Author(s):  
Baotong Zhang ◽  
Siyuan Xia ◽  
Mingcheng Liu ◽  
Xiawei Li ◽  
Shimin Shuai ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Progenitor Cells ◽  
Basal Progenitor

Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer

Development ◽  
1988 ◽  
Vol 104 (3) ◽  
pp. 473-482 ◽  
Author(s):  
J. Price ◽  
L. Thurlow
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Grey Matter ◽  
Cell Lineage ◽  
Cell Types ◽  
Retroviral Vector ◽  
Rat Cerebral Cortex ◽  
Rat Embryos ◽  
Bacterial Enzyme ◽  
Beta Galactosidase

We have used a retroviral vector that codes for the bacterial enzyme beta-galactosidase to study cell lineage in the rat cerebral cortex. This vector has been used to label progenitor cells in the cerebral cortices of rat embryos during the period of neurogenesis. When these embryos are allowed to develop to adulthood, the clones of cells derived from the marked progenitor cells can be identified histochemically. In this way, we can ask what are the lineage relationships between different neural cell types. From these studies, we conclude that there are two distinct types of progenitor cells in the developing cortex. One generates only grey matter astrocytes, whereas the second gives rise to neurones - both pyramidal and nonpyramidal - and to another class of cells that we have tentatively identified as glial cells of the white matter. We have also been able to address the question of how neurones are dispersed in the cortex during histogenesis. It had been previously hypothesized that clonally related neurones migrated radially to form columns in the mature cortex. However, we find that clones of neurones do not form radial columns; rather, they tend to occupy the same or neighbouring cortical laminae and to be spread over several hundreds of micrometers of cortex in the horizontal dimension. This spread occurs in both mediolateral and rostrocaudal directions.

scholarly journals Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

2009 ◽  
Vol 185 (6) ◽  
pp. 959-967 ◽  
Author(s):  
Takashi Ishiuchi ◽  
Kazuyo Misaki ◽  
Shigenobu Yonemura ◽  
Masatoshi Takeichi ◽  
Takuji Tanoue
Keyword(s):  
Cerebral Cortex ◽  
Plasma Membrane ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Apical Membrane ◽  
Neural Progenitor ◽  
Apical Plasma Membrane ◽  
Cell Contact ◽  
Membrane Organization ◽  
A Cell

Compartmentalization of the plasma membrane in a cell is fundamental for its proper functions. In this study, we present evidence that mammalian Fat4 and Dachsous1 cadherins regulate the apical plasma membrane organization in the embryonic cerebral cortex. In neural progenitor cells of the cortex, Fat4 and Dachsous1 were concentrated together in a cell–cell contact area positioned more apically than the adherens junction (AJ). These molecules interacted in a heterophilic fashion, affecting their respective protein levels. We further found that Fat4 associated and colocalized with the Pals1 complex. Ultrastructurally, the apical junctions of the progenitor cells comprised the AJ and a stretch of plasma membrane apposition extending apically from the AJ, which positionally corresponded to the Fat4–Dachsous1-positive zone. Depletion of Fat4 or Pals1 abolished this membrane apposition. These results highlight the importance of the Fat4–Dachsous1–Pals1 complex in organizing the apical membrane architecture of neural progenitor cells.

scholarly journals ADAM17 Is Critical for Multipolar Exit and Radial Migration of Neuronal Intermediate Progenitor Cells in Mice Cerebral Cortex

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65703 ◽  
Author(s):  
Qingyu Li ◽  
Zhengyu Zhang ◽  
Zengmin Li ◽  
Mei Zhou ◽  
Bin Liu ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Radial Migration
Sign in / Sign up

Export Citation Format

Share Document