Basal progenitor cells bridge the development, malignant cancers, and multiple diseases of esophagus

2017 ◽  
Vol 233 (5) ◽  
pp. 3855-3866
Author(s):  
Baoshun Lin ◽  
Fuan Xie ◽  
Zhangwu Xiao ◽  
Xiaoqian Hong ◽  
Liming Tian ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Basal Progenitor

Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain

2018 ◽  
Vol 78 (7) ◽  
pp. 660-670 ◽  
Author(s):  
Alice Grison ◽  
Carine Gaiser ◽  
Andrea Bieder ◽  
Constanze Baranek ◽  
Suzana Atanasoski
Keyword(s):  
Progenitor Cells ◽  
Basal Progenitor

scholarly journals HIV induces airway basal progenitor cells to adopt an inflammatory phenotype

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nancy P. Y. Chung ◽  
K. M. Faisal Khan ◽  
Robert J. Kaner ◽  
Sarah L. O’Beirne ◽  
Ronald G. Crystal
Keyword(s):  
Progenitor Cells ◽  
Inflammatory Mediators ◽  
Lung Inflammation ◽  
Mapk Signaling ◽  
Gm Csf ◽  
Basal Progenitor ◽  
Inflammatory Phenotype ◽  
Mapk Signaling Pathways ◽  
Chronic Hiv Infection

AbstractDespite the introduction of anti-retroviral therapy, chronic HIV infection is associated with an increased incidence of other comorbidities such as COPD. Based on the knowledge that binding of HIV to human airway basal stem/progenitor cells (BC) induces a destructive phenotype by increased MMP-9 expression through MAPK signaling pathways, we hypothesized that HIV induces the BC to express inflammatory mediators that contribute to the pathogenesis of emphysema. Our data demonstrate that airway BC isolated from HAART-treated HIV+ nonsmokers spontaneously release inflammatory mediators IL-8, IL-1β, ICAM-1 and GM-CSF. Similarly, exposure of normal BC to HIV in vitro up-regulates expression of the same inflammatory mediators. These HIV-BC derived mediators induce migration of alveolar macrophages (AM) and neutrophils and stimulate AM proliferation. This HIV-induced inflammatory phenotype likely contributes to lung inflammation in HIV+ individuals and provides explanation for the increased incidence of COPD in HIV+ individuals.

Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling

2021 ◽  
Author(s):  
Baotong Zhang ◽  
Siyuan Xia ◽  
Mingcheng Liu ◽  
Xiawei Li ◽  
Shimin Shuai ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Progenitor Cells ◽  
Basal Progenitor

538 OMEPRAZOLE TREATMENT RE-ESTABLIHES CD73+ BASAL PROGENITOR CELLS IN EOSINOPHILIC ESOPHAGITIS

2021 ◽  
Vol 160 (6) ◽  
pp. S-111
Author(s):  
Takeo Hara ◽  
Bailey Aaron ◽  
Adam Karami ◽  
Yuta Kasagi ◽  
Joshua Wang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Eosinophilic Esophagitis ◽  
Basal Progenitor

scholarly journals ROCK Inhibitor Increases Proacinar Cells in Adult Salivary Gland Organoids

2019 ◽  
Author(s):  
Matthew Koslow ◽  
Kevin J. O’Keefe ◽  
Deirdre A. Nelson ◽  
Melinda Larsen
Keyword(s):  
Progenitor Cells ◽  
Rho Kinase ◽  
List Type ◽  
Aquaporin 5 ◽  
Rock Inhibitor ◽  
Differentiation Potential ◽  
Basal Progenitor ◽  
Epithelial Progenitor Cells ◽  
Saliva Production

AbstractSalisphere-derived adult epithelial cells enriched for progenitor cells have been used to improve saliva production of irradiated mouse salivary glands. Importantly, optimization of the cellular composition of salispheres could improve their regenerative capabilities. The Rho Kinase (ROCK)1 inhibitor, Y27632, has been used to increase the proliferation and reduce apoptosis of progenitor cells grown in vitro. In this study, we investigated whether Y27632 in different cell media contexts could be used to improve expansion of adult epithelial progenitor cells or to affect their differentiation potential. Application of Y27632 in medium used previously to grow salispheres promoted expansion of Kit+ cells, while in simple serum-containing medium Y27632 increased the number of cells that expressed the K5 basal progenitor marker. When tested in a 3D organoid assay, Y27632 enhanced the contribution of adult salispheres to salivary organoids expressing the secretory proacinar marker Aquaporin 5 (AQP5) in response to FGF2 dependent mesenchymal signals. Optimization of epithelial-mesenchymal interactions organoids can be used to improve application of adult salivary progenitor cells in regenerative medicine strategies.HighlightsY27632 promotes Kit+ salisphere cell proliferation in salisphere media.Y27632 promotes K5 expression in salispheres cultured in serum containing media.Y27632 treated Kit+ salispheres form salivary organoids expressing AQP5.

scholarly journals Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells

2013 ◽  
Vol 12 (3) ◽  
pp. 304-315 ◽  
Author(s):  
Kuancan Liu ◽  
Ming Jiang ◽  
Yun Lu ◽  
Hao Chen ◽  
Jun Sun ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Malignant Transformation ◽  
Basal Progenitor

scholarly journals 09-P048 Tbr2 promotes the growth of the cerebral cortex specifying Intermediate (Basal) Progenitor Cells

2009 ◽  
Vol 126 ◽  
pp. S164
Author(s):  
Alessandro Sessa ◽  
Chai-An Mao ◽  
Anna-Katerina Hadjantonakis ◽  
William H. Klein ◽  
Vania Broccoli
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Basal Progenitor
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