scholarly journals Redundant ecdysis regulatory functions of three nuclear receptor HR3 isoforms in the direct-developing insect Blattella germanica

2007 ◽  
Vol 124 (3) ◽  
pp. 180-189 ◽  
Author(s):  
Josefa Cruz ◽  
David Martín ◽  
Xavier Bellés
Keyword(s):  
Nuclear Receptor ◽  
Blattella Germanica ◽  
Regulatory Functions

scholarly journals Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway

2017 ◽  
Vol 114 (33) ◽  
pp. 8841-8846 ◽  
Author(s):  
Shiwei Li ◽  
Qi Li ◽  
Yuanyuan Kong ◽  
Shuang Wu ◽  
Qingpo Cui ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Lipid Droplets ◽  
Nuclear Hormone Receptor ◽  
Dependent Manner ◽  
Hormone Synthesis ◽  
C Elegans ◽  
Human Cytochrome ◽  
Specific Regulation ◽  
Regulatory Functions

Nuclear receptors play important roles in regulating fat metabolism and energy production in humans. The regulatory functions and endogenous ligands of many nuclear receptors are still unidentified, however. Here, we report that CYP-37A1 (ortholog of human cytochrome P450 CYP4V2), EMB-8 (ortholog of human P450 oxidoreductase POR), and DAF-12 (homolog of human nuclear receptors VDR/LXR) constitute a hormone synthesis and nuclear receptor pathway in Caenorhabditis elegans. This pathway specifically regulates the thermosensitive fusion of fat-storing lipid droplets. CYP-37A1, together with EMB-8, synthesizes a lipophilic hormone not identical to Δ7-dafachronic acid, which represses the fusion-promoting function of DAF-12. CYP-37A1 also negatively regulates thermotolerance and lifespan at high temperature in a DAF-12–dependent manner. Human CYP4V2 can substitute for CYP-37A1 in C. elegans. This finding suggests the existence of a conserved CYP4V2-POR–nuclear receptor pathway that functions in converting multilocular lipid droplets to unilocular ones in human cells; misregulation of this pathway may lead to pathogenic fat storage.

The Versatility of Adhesion Receptor Ligands in Haemostasis: Morpho-Regulatory Functions of Vitronectin

1995 ◽  
Vol 74 (01) ◽  
pp. 258-265 ◽  
Author(s):  
Sibylle Hess ◽  
Sandip M Kanse ◽  
Christine Kost ◽  
Klaus T Preissner
Keyword(s):  
Receptor Ligands ◽  
Adhesion Receptor ◽  
Regulatory Functions
Sign in / Sign up

Export Citation Format

Share Document