Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica

2012 ◽  
Vol 348 (1) ◽  
pp. 322-330 ◽  
Author(s):  
Daniel Mané-Padrós ◽  
Ferran Borràs-Castells ◽  
Xavier Belles ◽  
David Martín
Keyword(s):  
Nuclear Receptor ◽  
Essential Role ◽  
Blattella Germanica ◽  
Hemimetabolous Insect

scholarly journals An Essential Role of Domain D in the Hormone-Binding Activity of Human β1 Thyroid Hormone Nuclear Receptor

1991 ◽  
Vol 5 (4) ◽  
pp. 485-492 ◽  
Author(s):  
Kwang-Huei Lin ◽  
Clifford Parkison ◽  
Peter McPhie ◽  
Sheue-yann Cheng
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Essential Role ◽  
Binding Activity ◽  
Hormone Binding

Su1108 THE THYROID HORMONE NUCLEAR RECEPTOR TRa1 PLAYS AN ESSENTIAL ROLE IN INTESTINAL EPITHELIUM STEM CELL PHYSIOPATHOLOGY

2020 ◽  
Vol 158 (6) ◽  
pp. S-510-S-511
Author(s):  
Maria Virginia Giolito ◽  
Leo Claret ◽  
Frau Carla ◽  
Michelina Plateroti
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Intestinal Epithelium ◽  
Essential Role

scholarly journals Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

2005 ◽  
Vol 25 (9) ◽  
pp. 3492-3505 ◽  
Author(s):  
Peili Gu ◽  
Bryan Goodwin ◽  
Arthur C.-K. Chung ◽  
Xueping Xu ◽  
David A. Wheeler ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Nuclear Receptor ◽  
Essential Role ◽  
Inner Cell Mass ◽  
Es Cells ◽  
Cell Mass ◽  
Embryonic Stem ◽  
Cell Lineage ◽  
Proximal Promoter ◽  
Orphan Nuclear Receptor

ABSTRACT Oct4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES) cells. The expression of Oct4 is regulated by the proximal enhancer and promoter in the epiblast and by the distal enhancer and promoter at all other stages in the pluripotent cell lineage. Here we report that the orphan nuclear receptor LRH-1, which is expressed in undifferentiated ES cells, can bind to SF-1 response elements in the proximal promoter and proximal enhancer of the Oct4 gene and activate Oct4 reporter gene expression. LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early developmental stages. Disruption of the LRH-1 gene results in loss of Oct4 expression at the epiblast stage and early embryonic death. Using LRH-1 −/− ES cells, we also show that LRH-1 is required to maintain Oct4 expression at early differentiation time points. In vitro and in vivo results show that LRH-1 plays an essential role in the maintenance of Oct4 expression in ES cells at the epiblast stage of embryonic development, thereby maintaining pluripotence at this crucial developmental stage prior to segregation of the primordial germ cell lineage at gastrulation.

scholarly journals The Role of the Orphan Nuclear Receptor, Liver Receptor Homologue-1, in the Regulation of Human Corpus Luteum 3β-Hydroxysteroid Dehydrogenase Type II

2003 ◽  
Vol 88 (12) ◽  
pp. 6020-6028 ◽  
Author(s):  
Noel Peng ◽  
Joung W. Kim ◽  
William E. Rainey ◽  
Bruce R. Carr ◽  
George R. Attia
Keyword(s):  
Corpus Luteum ◽  
Nuclear Receptor ◽  
Essential Role ◽  
Fold Increase ◽  
Hydroxysteroid Dehydrogenase ◽  
Orphan Nuclear Receptor ◽  
Type Ii ◽  
Genes Encoding ◽  
Human Corpus Luteum

Abstract After ovulation, ovarian 3β-hydroxysteroid dehydrogenase type II (HSD3B2) expression increases to enhance the shift of steroidogenesis toward progesterone biosynthesis. Steroidogenic factor-1 (SF-1) is a transcription factor for several genes encoding steroidogenic enzymes. However, the level of SF-1 expression decreases in the human corpus luteum (CL) after ovulation. Liver receptor homolog-1 (LRH-1) is another member of the orphan nuclear receptor family. We hypothesize that LRH-1, rather than SF-1, plays an essential role in the regulation of corpus luteum steroidogenesis. Semiquantitative RT-PCR and real-time PCR were performed to quantify the level of LRH-1 expression and correlate with HSD3B2 level. Cell transfection, mutation analysis, and EMSA were performed to examine the role of LRH-1 in the regulation of HSD3B2. LRH-1 expression was higher in CL, compared with mature ovarian follicles. Cotransfection of granulosa cells with HSD3B2 and LRH-1 resulted in a 10-fold increase of transcription. DAX-1 inhibited LRH-1-stimulated HSD3B2, which was maintained in the presence of dibutyryl cAMP. Mutation of the either of the two putative LRH-1 binding sites, which were confirmed by EMSA, in the HSD3B2 promoter decreased LRH-1 stimulation. Our findings suggest that LRH-1 is highly expressed in CL, and it plays an essential role in the regulation of HSD3B2.

scholarly journals DTL, theDrosophilaHomolog of PIMT/Tgs1 Nuclear Receptor Coactivator-interacting Protein/RNA Methyltransferase, Has an Essential Role in Development

2005 ◽  
Vol 280 (13) ◽  
pp. 12397-12404 ◽  
Author(s):  
Orbán Komonyi ◽  
Gábor Pápai ◽  
Izzet Enunlu ◽  
Selen Muratoglu ◽  
Tibor Pankotai ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Essential Role ◽  
Nuclear Receptor Coactivator ◽  
Interacting Protein
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