Oxygen consumption by cultured human cells is impaired by a nucleoside analogue cocktail that inhibits mitochondrial DNA synthesis

Mitochondrion ◽  
2005 ◽  
Vol 5 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Caroline Petit ◽  
France Piétri-Rouxel ◽  
Annick Lesne ◽  
Thierry Leste-Lasserre ◽  
Dominique Mathez ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxygen Consumption ◽  
Dna Synthesis ◽  
Nucleoside Analogue ◽  
Human Cells ◽  
Cultured Human Cells ◽  
Mitochondrial Dna Synthesis

scholarly journals Influence of hydroxyurea on the course of germination and growth of rape (Brasica napus L.) seedlings

2015 ◽  
Vol 47 (1–2) ◽  
pp. 131-141 ◽  
Author(s):  
M. Kuraś ◽  
H. Teleżyński
Keyword(s):  
Mitochondrial Dna ◽  
Root Growth ◽  
Dna Synthesis ◽  
Elongation Growth ◽  
Complete Inhibition ◽  
Hypocotyl Growth ◽  
Prolonged Incubation ◽  
Inhibition Of Growth ◽  
Germination And Growth ◽  
Mitochondrial Dna Synthesis

The effects of continuous incubation in hydroxyurea (HU) solutions (0.2, 0.4, 0.8 mg/ml) on germination of rape seeds and growth of young seedling axes were studied during 132 hours from initial soaking. Germination turned out to be unaffected by the treatment. Root growth was first increasingly inhibited by the HU concentration tested, but after prolonged incubation a complete arrest of the root growth was noted at all HU concentrations. The elongation growth of hypocotyls was found to be stimulated by a HU 0.2 mg/ml concentration while it was markedly suppressed by 0.4 mg/ml, and completely arrested by 0.8 mg/ml Inhibition of growth of the upright hypocotyl part at higher HU concentration was found to be accompanied by the unbending of the hooked under-cotyledonary part. It is suggested that inhibition of nuclear endomitotic DNA synthesis In elongating hypocotyl cells, suppresses only partially their growth, whereas a complete inhibition of the hypocotyl growth results from arrest of the mitochondrial DNA synthesis.

scholarly journals New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Nature ◽  
2018 ◽  
Vol 560 (7717) ◽  
pp. 198-203 ◽  
Author(s):  
Zhenyu Zhong ◽  
Shuang Liang ◽  
Elsa Sanchez-Lopez ◽  
Feng He ◽  
Shabnam Shalapour ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Synthesis ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Mitochondrial Dna Synthesis
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