Worn-out oxide MOSFET characteristics: Role of gate current and device parameters on a current mirror

2007 ◽  
Vol 47 (4-5) ◽  
pp. 665-668 ◽  
Author(s):  
J. Martín-Martínez ◽  
R. Rodríguez ◽  
M. Nafría ◽  
X. Aymerich ◽  
J.H. Stathis
Keyword(s):  
Current Mirror ◽  
Gate Current ◽  
A Current

Role of Regulatory Acts in Creation of a Democratic State

2020 ◽  
pp. 82-86
Author(s):  
R. F.o. Veliev
Keyword(s):  
Russian Federation ◽  
Legal Norm ◽  
Legal Basis ◽  
Democratic State ◽  
The Russian Federation ◽  
A Current

A current theoretical and practical legal basis for creation of regulatory acts in the Russian Federation is discussed. A current relationship between the issued regulatory acts and some criteria of legal norm classification is shown. Legalization of the President address to the Parliament of the Russian Federation as a substantial element of the legal norm-making in a democratic state is revealed.

Audit Reviewers' Judgments in Multiple Client Audit Environments

2017 ◽  
Vol 29 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Sudip Bhattacharjee ◽  
Mario J. Maletta ◽  
Kimberly K. Moreno
Keyword(s):  
Audit Quality ◽  
Internal Audit ◽  
Contrast Effects ◽  
Comparative Information ◽  
A Current

ABSTRACT This study replicates Bhattacharjee, Maletta, and Moreno (2007), who find that audit preparers are susceptible to contrast effects in a multi-client environment. We demonstrate that auditors in the role of reviewers are also susceptible to contrast effects from a prior client. Audit reviewers' assessments of internal audit quality of a current client were significantly affected by the quality of the internal audit group of a client they previously reviewed. Specifically, when auditors first reviewed a client with a weak internal audit group they assessed the subsequent moderate internal audit group as being of higher quality than when they first reviewed a prior client with a strong internal audit group or did not review a prior client. Reviewers' documentation of evidence was also influenced by comparative information from the prior client. These results corroborate the key findings of Bhattacharjee et al. (2007) and confirm audit reviewers' susceptibility to contrast effects.

Magnesium and Hearing

2003 ◽  
Vol 14 (04) ◽  
pp. 202-212 ◽  
Author(s):  
Michael J. Cevette ◽  
Jürgen Vormann ◽  
Kay Franz
Keyword(s):  
Hair Cells ◽  
Auditory Nerve ◽  
Mg Deficiency ◽  
Noise Damage ◽  
Susceptibility To Noise ◽  
Major Progress ◽  
A Current ◽  
Putative Mechanism ◽  
Increased Susceptibility

The last several decades have revealed clinical and experimental data regarding the importance of magnesium (Mg) in hearing. Increased susceptibility to noise damage, ototoxicity, and auditory hyperexcitibility are linked to states of Mg deficiency. Evidence for these processes has come slowly and direct effects have remained elusive because plasma Mg levels do not always correlate with its deficiency. Despite the major progress in the understanding of cochlear mechanical and auditory nerve function, the neurochemical and pharmacologic role of Mg is not clear. The putative mechanism suggests that Mg deficiency may contribute to a metabolic cellular cascade of events. Mg deficiency leads to an increased permeability of the calcium channel in the hair cells with a consequent over influx of calcium, an increased release of glutamate via exocytosis, and over stimulation of NMDA receptors on the auditory nerve. This paper provides a current overview of relevant Mg metabolism and deficiency and its influence on hearing.

scholarly journals Role of Bradykinin Type 2 Receptors in Human Sweat Secretion: Translational Evidence Does Not Support a Functional Relationship

2021 ◽  
Vol 34 (3) ◽  
pp. 162-166
Author(s):  
Thad E. Wilson ◽  
Seetharam Narra ◽  
Kristen Metzler-Wilson ◽  
Artur Schneider ◽  
Kelsey A. Bullens ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Sweat Rate ◽  
Sweat Glands ◽  
Potential Therapeutic Target ◽  
Sweat Secretion ◽  
Hoe 140 ◽  
A Current

Bradykinin increases skin blood flow via a cGMP mechanism but its role in sweating in vivo is unclear. There is a current need to translate cell culture and nonhuman paw pad studies into in vivo human preparations to test for therapeutic viability for disorders affecting sweat glands. Protocol 1: physiological sweating was induced in 10 healthy subjects via perfusing warm (46–48°C) water through a tube-lined suit while bradykinin type 2 receptor (B2R) antagonist (HOE-140; 40 μM) and only the vehicle (lactated Ringer’s) were perfused intradermally via microdialysis. Heat stress increased sweat rate (HOE-140 = +0.79 ± 0.12 and vehicle = +0.64 ± 0.10 mg/cm<sup>2</sup>/min), but no differences were noted with B2R antagonism. Protocol 2: pharmacological sweating was induced in 6 healthy subjects via intradermally perfusing pilocarpine (1.67 mg/mL) followed by the same B2R antagonist approach. Pilocarpine increased sweating (HOE-140 = +0.38 ± 0.16 and vehicle = +0.32 ± 0.12 mg/cm<sup>2</sup>/min); again no differences were observed with B2R antagonism. Last, 5 additional subjects were recruited for various control experiments which identified that a functional dose of HOE-140 was utilized and it was not sudorific during normothermic conditions. These data indicate B2R antagonists do not modulate physiologically or pharmacologically induced eccrine secretion volumes. Thus, B2R agonist/antagonist development as a potential therapeutic target for hypo- and hyperhidrosis appears unwarranted.

scholarly journals Heterokairy: a significant form of developmental plasticity?

2016 ◽  
Vol 12 (9) ◽  
pp. 20160509 ◽  
Author(s):  
S. D. Rundle ◽  
J. I. Spicer
Keyword(s):  
Research Agenda ◽  
Developmental Plasticity ◽  
Potential Role ◽  
Research Effort ◽  
Adaptive Significance ◽  
Research Interest ◽  
Adaptive Plasticity ◽  
Comparative Embryology ◽  
A Current

There is a current surge of research interest in the potential role of developmental plasticity in adaptation and evolution. Here we make a case that some of this research effort should explore the adaptive significance of heterokairy, a specific type of plasticity that describes environmentally driven, altered timing of development within a species. This emphasis seems warranted given the pervasive occurrence of heterochrony, altered developmental timing between species, in evolution. We briefly review studies investigating heterochrony within an adaptive context across animal taxa, including examples that explore links between heterokairy and heterochrony. We then outline how sequence heterokairy could be included within the research agenda for developmental plasticity. We suggest that the study of heterokairy may be particularly pertinent in (i) determining the importance of non-adaptive plasticity, and (ii) embedding concepts from comparative embryology such as developmental modularity and disassociation within a developmental plasticity framework.

scholarly journals Heparin-induced thrombocytopenia: research and clinical updates

Hematology ◽  
2016 ◽  
Vol 2016 (1) ◽  
pp. 262-268 ◽  
Author(s):  
Oluwatoyosi Onwuemene ◽  
Gowthami M. Arepally
Keyword(s):  
Limited Data ◽  
Platelet Factor ◽  
Heparin Induced Thrombocytopenia ◽  
Diagnostic Strategies ◽  
Immune Mediated ◽  
Emerging Therapies ◽  
Current Perspective ◽  
Clinical Advances ◽  
A Current

Abstract Heparin-induced thrombocytopenia (HIT) remains an important diagnosis to consider in hospitalized patients developing thrombocytopenia. HIT is an immune-mediated prothrombotic disorder caused by antibodies to platelet factor 4 (PF4) and heparin. Recent basic scientific studies have advanced our understanding of disease pathogenesis through studies of the PF4/heparin structure, immune mechanisms, and cellular basis of thrombosis. Clinical advances have also occurred in areas of HIT prevention, description of disease variants, and diagnostic strategies. Emerging anticoagulants with the potential to change HIT treatment are evolving, although with limited data. This review will provide a current perspective on HIT pathogenesis, disease features, diagnostic strategies, and role of emerging therapies for the management of HIT.

Abstract TP147: Central Post Stroke Pain: A Systematic Review

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jonathan Singer ◽  
Alyssa Conigliaro ◽  
Elizabeth Spina ◽  
Susan Law ◽  
Steven Levine
Keyword(s):  
Systematic Review ◽  
Brain Imaging ◽  
Pain Scale ◽  
Post Stroke ◽  
Underlying Causes ◽  
Single Question ◽  
Thalamic Region ◽  
The Brain ◽  
A Current

Background: Central Post Stroke Pain (CPSP) is reportedly due to strokes in the thalamic region (Dishinbition Theory); however, the Central Imbalance Theory states that CPSP is due to damage to the spinothalamic pathway (STP). Aims: 1) Clarify the role of thalamic strokes and STP damage in CPSP patients. 2) Gain a current understanding of anatomic substrates, brain imaging, and treatment of CPSP. Methods: Two independent reviewers systematically reviewed PUBMED, CINAHL and Web of Science for studies including original, clinical studies and randomized controlled trials (RCTs) using PRISMA guidelines. Studies had to assess CPSP, using a single question or pain scale. Results: Search from January – July 2016, identifying 731 publications. We extracted data from 23 studies and categorized the articles’ aims into 4 sections: somatosensory deficits (5 studies), STP (3 studies), brain imaging (7 studies), and RCTs (8 studies). Somatosensory studies showed high rates of CPSP; however, the underlying causes of these deficits were unclear. Most studies did not refer to stroke location as playing a role in CPSP, but that pathways may. STP studies displayed consistent evidence that the STP plays a major role in CPSP, delineating that CPSP can occur even when the stroke is not in the thalamic region but in other regions (e.g. cerebellum, basal ganglia, medulla). Four of the brain imaging studies found CPSP not related and 3 found it was related to thalamic strokes. All 7 studies had major limitations including sample size, no control groups, and selection bias. RCTs were mostly negative, but brain stem and motor cortex stimulation studies showed the most promise. Conclusions: While CPSP has been linked to the thalamic region since the early 1900’s, the peer-reviewed literature showed equivocal results when examining location of stroke. Our systematic review suggests damage to the STP is associated with CPSP and this could provide insights into mechanisms and treatment. Moreover, historical connection of strokes in the thalamic region and CPSP should be reevaluated as many studies noted that strokes in other regions of the brain also produce CPSP.

scholarly journals Students' engagement in school and family variables: A literature review

2016 ◽  
Vol 33 (2) ◽  
pp. 187-197 ◽  
Author(s):  
Feliciano Henriques VEIGA ◽  
Viorel ROBU ◽  
Joseph CONBOY ◽  
Adriana ORTIZ ◽  
Carolina CARVALHO ◽  
...  
Keyword(s):  
Parental Support ◽  
State Of The Art ◽  
Empirical Studies ◽  
Dropping Out ◽  
School Variables ◽  
Family Contexts ◽  
Perceived Parental Support ◽  
Family Variables ◽  
A Current

"Students' engagement in school" is regarded in the literature as a current and valued construct despite the lack of empirical studies on its relationship with specific family variables. The present research aimed to survey studies on the correlation between students' engagement in school and family contexts, specifically in terms of the following variables: perceived parental support, socioeconomic and sociocultural levels, perceived rights, and parental educational styles. In order to describe the state of the art of student's "engagement in school" and "family variables", a narrative review was conducted. The studies reviewed highlight the role of family as a context with significance in student's engagement in school. However, further research is needed to deepen the knowledge of this topic considering potential mediator variables, either personal or school variables. It was also found the need for a psychosocial intervention aimed at providing support for the students coming from adverse family contexts who exhibit low level of engagement associated with poor academic achievement and a higher probability of dropping out.

scholarly journals Almacenamiento energético frente al inminente paradigma renovable: el rol de las baterías ion-litio y las perspectivas sudamericanas/Energy storage towards the imminent renewable paradigm: the role of ion-lithium batteries and South American perspectives

2018 ◽  
pp. 108-132 ◽  
Author(s):  
Martin Ariel Kazimierski
Keyword(s):  
Electric Propulsion ◽  
Fossil Fuels ◽  
Lithium Ion ◽  
Energy System ◽  
South American ◽  
Potential Market ◽  
Wide Range ◽  
New Energy ◽  
A Current

El actual sistema energético mundial se caracteriza por una alta dependencia de los combustibles fósiles, un paradigma que empieza a encontrar dificultades en tanto se agotan las reservas existentes y aumentan los costos ecológicos. Así, la incorporación de energías renovables, su generación en forma distribuida y el crecimiento del parque automotor eléctrico, se presentan como la triada más prometedora en la conformación de un nuevo paradigma más eficiente y sustentable. Este artículo se centra en la importancia que adquieren los acumuladores energéticos ante este panorama, principalmente por su rol en la estabilización de las redes y posibilitar el autoconsumo y la propulsión eléctrica. Identifica en las baterías de ion-litio un abanico de posibilidades para Sudamérica, que posee las reservas más importantes de litio en el mundo, incorporando la idea del desarrollo dentro del nuevo patrón energético y en un mercado actual y potencial de grandes dimensiones. Abstract The current global energy system is characterized by a high dependence on fossil fuels, a paradigm that begins to encounter difficulties as existing reserves are depleted and ecological costs increase. Thus, the incorporation of renewable energies, their generation in a distributed form and the growth of the electric motor park, are presented as the most promising triad in the conformation of a new, more efficient and sustainable paradigm. This article focuses on the importance that energy accumulators acquire in this scenario, mainly due to their role in stabilizing networks and enabling self-consumption and electric propulsion. It identifies lithium-ion batteries with a wide range of possibilities for South America, which has the most important reserves of lithium in the world, incorporating the idea of ​​development within the new energy pattern and in a current and potential market of large dimensions.

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