Metabolomics analysis reveals the mechanisms of the effect of Sijunzi decoction on spleen deficiency syndrome in a rat model

2020 ◽  
Vol 152 ◽  
pp. 104422 ◽  
Author(s):  
Qinghua Yan ◽  
Huili Mao ◽  
Jianyi Guan
Keyword(s):  
Rat Model ◽  
Deficiency Syndrome ◽  
Spleen Deficiency ◽  
Spleen Deficiency Syndrome ◽  
Metabolomics Analysis

scholarly journals Effects of Electroacupuncture with Dominant Frequency at SP 6 and ST 36 Based on Meridian Theory on Pain-Depression Dyad in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuan-yuan Wu ◽  
Yong-liang Jiang ◽  
Xiao-fen He ◽  
Xiao-yun Zhao ◽  
Xiao-mei Shao ◽  
...  
Keyword(s):  
Open Field ◽  
Rat Model ◽  
Maximum Velocity ◽  
Deficiency Syndrome ◽  
Dominant Frequency ◽  
Emotional Behavior ◽  
Spleen Deficiency ◽  
Withdrawal Latency ◽  
Spleen Deficiency Syndrome

Epidemic investigations reveal an intimate interrelationship between pain and depression. The effect of electroacupuncture (EA) on pain or depression has been demonstrated individually, but its effect on pain-depression dyad is unknown. Our study aimed to screen a dominant EA frequency on pain-depression dyad and determine the validity of acupoint selection based on meridian theory. The pain-depression dyad rat model was induced by reserpine and treated using EA with different frequencies at identical acupoints to extract a dominant frequency and then administrated dominant-frequency EA at different acupoints in the above models. Paw withdrawal latency (PWL), emotional behavior of elevated zero maze (EZM) test, and open field (OF) test were conducted. We found that 100 Hz EA at Zusanli (ST 36) and Sanyinjiao (SP 6) (classical acupoints for spleen-deficiency syndrome) were the most effective in improving PWL, travelling distance in the EZM, and maximum velocity in OF compared to EA with other frequencies; ST 36 and SP 6 were proved more effective than other acupoints beyond the meridian theory and nonacupoints under the same administration of EA. Therefore, we concluded that 100 Hz is the dominant frequency for treating the pain-depression dyad with EA, and acupoints on spleen and stomach meridians are preferable choices.

A combination of depression and liver Qi stagnation and spleen deficiency syndrome using a rat model

2020 ◽  
Vol 303 (8) ◽  
pp. 2154-2167 ◽  
Author(s):  
Xiao‐Juan Li ◽  
Wen‐Qi Qiu ◽  
Xiao‐Li Da ◽  
Ya‐Jing Hou ◽  
Qing‐Yu Ma ◽  
...  
Keyword(s):  
Rat Model ◽  
Deficiency Syndrome ◽  
Spleen Deficiency ◽  
Qi Stagnation ◽  
Spleen Deficiency Syndrome
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