A combination of depression and liver Qi stagnation and spleen deficiency syndrome using a rat model

2020 ◽  
Vol 303 (8) ◽  
pp. 2154-2167 ◽  
Author(s):  
Xiao‐Juan Li ◽  
Wen‐Qi Qiu ◽  
Xiao‐Li Da ◽  
Ya‐Jing Hou ◽  
Qing‐Yu Ma ◽  
...  
Keyword(s):  
Rat Model ◽  
Deficiency Syndrome ◽  
Spleen Deficiency ◽  
Qi Stagnation ◽  
Spleen Deficiency Syndrome

scholarly journals Effects of Electroacupuncture with Dominant Frequency at SP 6 and ST 36 Based on Meridian Theory on Pain-Depression Dyad in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuan-yuan Wu ◽  
Yong-liang Jiang ◽  
Xiao-fen He ◽  
Xiao-yun Zhao ◽  
Xiao-mei Shao ◽  
...  
Keyword(s):  
Open Field ◽  
Rat Model ◽  
Maximum Velocity ◽  
Deficiency Syndrome ◽  
Dominant Frequency ◽  
Emotional Behavior ◽  
Spleen Deficiency ◽  
Withdrawal Latency ◽  
Spleen Deficiency Syndrome

Epidemic investigations reveal an intimate interrelationship between pain and depression. The effect of electroacupuncture (EA) on pain or depression has been demonstrated individually, but its effect on pain-depression dyad is unknown. Our study aimed to screen a dominant EA frequency on pain-depression dyad and determine the validity of acupoint selection based on meridian theory. The pain-depression dyad rat model was induced by reserpine and treated using EA with different frequencies at identical acupoints to extract a dominant frequency and then administrated dominant-frequency EA at different acupoints in the above models. Paw withdrawal latency (PWL), emotional behavior of elevated zero maze (EZM) test, and open field (OF) test were conducted. We found that 100 Hz EA at Zusanli (ST 36) and Sanyinjiao (SP 6) (classical acupoints for spleen-deficiency syndrome) were the most effective in improving PWL, travelling distance in the EZM, and maximum velocity in OF compared to EA with other frequencies; ST 36 and SP 6 were proved more effective than other acupoints beyond the meridian theory and nonacupoints under the same administration of EA. Therefore, we concluded that 100 Hz is the dominant frequency for treating the pain-depression dyad with EA, and acupoints on spleen and stomach meridians are preferable choices.

scholarly journals UPLC-QTOF/MS-Based Lipidomic Profiling of Liver Qi-Stagnation and Spleen-Deficiency Syndrome in Patients with Hyperlipidemia

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Piao Shenghua ◽  
Tan Shuyu ◽  
Li Kunping ◽  
Zhan Huixia ◽  
Xiao Xue ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Plasma Lipid ◽  
Deficiency Syndrome ◽  
Common Disease ◽  
Database Searching ◽  
Efficient Technology ◽  
Spleen Deficiency ◽  
Qi Stagnation ◽  
Lipid Metabolites ◽  
Spleen Deficiency Syndrome

Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism. Lipidomics is a powerful and efficient technology to study the integration of disease and syndrome of Chinese medicine. This study investigated specific changes in lipid metabolites from hyperlipidemia patients with syndrome of liver qi-stagnation and spleen-deficiency (SLQSD). Lipid profiles in plasma samples from 29 hyperlipidemia patients including 10 SLQSD and 19 non-SLQSD and 26 healthy volunteers (NC) were tested by UPLC-QTOF/MS. PLS-DA analysis and database searching were performed to discover differentiating metabolites. Differences in lipid metabolites between hyperlipidemia and healthy people mainly include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, and ceramides. Hyperlipidemia patients with SLQSD and non-SLQSD could be differentiated by using identified lipid metabolites including phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, triglycerides, diacylglycerols, lysophosphatidylethanolamines, sphingomyelins, lysophosphatidylcholines, and lactosylceramides. There were significant differences of lipid metabolism between between different syndromes of the same disease such as hyperlipidemia which showed significant differences between SLQSD and non-SLQSD.

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