scholarly journals Document ink dye age estimation by direct injection-mass spectrometry and correlation analysis

2019 ◽  
Vol 147 ◽  
pp. 1123-1132 ◽  
Author(s):  
Karina F.F. Costa ◽  
Guilherme D. Brand ◽  
Tatiane S. Grobério ◽  
Jez W.B. Braga ◽  
Jorge J. Zacca
Keyword(s):  
Mass Spectrometry ◽  
Correlation Analysis ◽  
Age Estimation ◽  
Direct Injection ◽  
Direct Injection Mass Spectrometry

scholarly journals Comparative Metabolomic Study of Drosophila Species with Different Lifespans

2021 ◽  
Vol 22 (23) ◽  
pp. 12873
Author(s):  
Dmitry L. Maslov ◽  
Nadezhda V. Zemskaya ◽  
Oxana P. Trifonova ◽  
Steven Lichtenberg ◽  
Elena E. Balashova ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metabolite Profiling ◽  
Direct Injection ◽  
Lifespan Extension ◽  
World Population ◽  
Comparison Study ◽  
Age Related ◽  
The World ◽  
Direct Injection Mass Spectrometry ◽  
Metabolomic Study

The increase in life expectancy, leading to a rise in the proportion of older people, is accompanied by a prevalence of age-related disorders among the world population, the fight against which today is one of the leading biomedical challenges. Exploring the biological insights concerning the lifespan is one of the ways to provide a background for designing an effective treatment for the increase in healthy years of life. Untargeted direct injection mass spectrometry-based metabolite profiling of 12 species of Drosophila with significant variations in natural lifespans was conducted in this research. A cross-comparison study of metabolomic profiles revealed lifespan signatures of flies. These signatures indicate that lifespan extension is associated with the upregulation of amino acids, phospholipids, and carbohydrate metabolism. Such information provides a metabolome-level view on longevity and may provide a molecular measure of organism age in age-related studies.

Development of a new phenotypic roadmap to improve strawberry aroma based on direct injection mass spectrometry

2021 ◽  
pp. 971-978
Author(s):  
B. Farneti ◽  
I. Khomenko ◽  
M. Pietrella ◽  
P. Martinatti ◽  
F. Emanuelli ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Direct Injection ◽  
Direct Injection Mass Spectrometry

scholarly journals Evaluation and validation of an analytical approach for high-throughput metabolomic fingerprinting using direct introduction–high-resolution mass spectrometry: Applicability to classification of urine of scrapie-infected ewes

2018 ◽  
Vol 25 (2) ◽  
pp. 251-258 ◽  
Author(s):  
Estelle Rathahao-Paris ◽  
Sandra Alves ◽  
Nawel Boussaid ◽  
Nicole Picard-Hagen ◽  
Véronique Gayrard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Throughput ◽  
Biological Samples ◽  
Matrix Effects ◽  
Mass Measurement ◽  
Direct Injection ◽  
Mass Spectrometry Data ◽  
Direct Injection Mass Spectrometry

Direct injection–mass spectrometry can be used to perform high-throughput metabolomic fingerprinting. This work aims to evaluate a global analytical workflow in terms of sample preparation (urine sample dilution), high-resolution detection (quality of generated data based on criteria such as mass measurement accuracy and detection sensitivity) and data analysis using dedicated bioinformatics tools. Investigation was performed on a large number of biological samples collected from sheep infected or not with scrapie. Direct injection–mass spectrometry approach is usually affected by matrix effects, eventually hampering detection of some relevant biomarkers. Reference compounds were spiked in biological samples to help evaluate the quality of direct injection–mass spectrometry data produced by Fourier Transform mass spectrometry. Despite the potential of high-resolution detection, some drawbacks still remain. The most critical is the presence of matrix effects, which could be minimized by optimizing the sample dilution factor. The data quality in terms of mass measurement accuracy and reproducible intensity was evaluated. Good repeatability was obtained for the chosen dilution factor (i.e., 2000). More than 150 analyses were performed in less than 16 hours using the optimized direct injection–mass spectrometry approach. Discrimination of different status of sheeps in relation to scrapie infection (i.e., scrapie-affected, preclinical scrapie or healthy) was obtained from the application of Shrinkage Discriminant Analysis to the direct injection–mass spectrometry data. The most relevant variables related to this discrimination were selected and annotated. This study demonstrated that the choice of appropriated dilution faction is indispensable for producing quality and informative direct injection–mass spectrometry data. Successful application of direct injection–mass spectrometry approach for high throughput analysis of a large number of biological samples constitutes the proof of the concept.

High Throughput and Low Bias DNA Methylation and Hydroxymethylation Analysis by Direct Injection Mass Spectrometry

2021 ◽  
pp. 338880
Author(s):  
Yan Sun ◽  
Stephanie Stransky ◽  
Jennifer Aguilan ◽  
Sanjay Koul ◽  
Scott J. Garforth ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dna Methylation ◽  
High Throughput ◽  
Direct Injection ◽  
Direct Injection Mass Spectrometry

Determination of naphthalene and total methylnaphthalenes in gasoline using direct injection-mass spectrometry

Talanta ◽  
2007 ◽  
Vol 72 (1) ◽  
pp. 256-262 ◽  
Author(s):  
J PAVON ◽  
M SANCHEZ ◽  
M LAESPADA ◽  
C PINTO ◽  
B CORDERO
Keyword(s):  
Mass Spectrometry ◽  
Direct Injection ◽  
Direct Injection Mass Spectrometry

Direct injection mass spectrometry, thin layer chromatography, and gas chromatography of Bacillus subtilis phospholipids

2016 ◽  
Vol 147 (8) ◽  
pp. 1385-1391 ◽  
Author(s):  
Václav Matěj Bierhanzl ◽  
Radomír Čabala ◽  
Martin Ston ◽  
Peter Kotora ◽  
Viktória Ferenczy ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Bacillus Subtilis ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Direct Injection ◽  
Layer Chromatography ◽  
Direct Injection Mass Spectrometry
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