Plant nutraceuticals (Quercetrin and Afzelin) capped silver nanoparticles exert potent antibiofilm effect against food borne pathogen Salmonella enterica serovar Typhi and curtail planktonic growth in zebrafish infection model

2018 ◽  
Vol 120 ◽  
pp. 109-118 ◽  
Author(s):  
Robert Lotha ◽  
Niranjana Sri Sundaramoorthy ◽  
Bhanuvalli R. Shamprasad ◽  
Saisubramanian Nagarajan ◽  
Aravind Sivasubramanian
Keyword(s):  
Silver Nanoparticles ◽  
Salmonella Enterica ◽  
Infection Model ◽  
Salmonella Enterica Serovar Typhi ◽  
Planktonic Growth ◽  
Food Borne ◽  
Zebrafish Infection

scholarly journals The Potassium Transporter Trk and External Potassium Modulate Salmonella enterica Protein Secretion and Virulence

2008 ◽  
Vol 77 (2) ◽  
pp. 667-675 ◽  
Author(s):  
Jing Su ◽  
Hao Gong ◽  
Jeff Lai ◽  
Andrew Main ◽  
Sangwei Lu
Keyword(s):  
Salmonella Enterica ◽  
Bacterial Pathogen ◽  
Effector Proteins ◽  
Host Cells ◽  
Infection Model ◽  
Human Pathogens ◽  
Food Borne ◽  
External Potassium ◽  
Living Organisms ◽  
External K

ABSTRACT Potassium (K+) is the most abundant intracellular cation and is essential for many physiological functions of all living organisms; however, its role in the pathogenesis of human pathogens is not well understood. In this study, we characterized the functions of the bacterial Trk K+ transport system and external K+ in the pathogenesis of Salmonella enterica, a major food-borne bacterial pathogen. Here we report that Trk is important for Salmonella to invade and grow inside epithelial cells. It is also necessary for the full virulence of Salmonella in an animal infection model. Analysis of proteins of Salmonella indicated that Trk is involved in the expression and secretion of effector proteins of the type III secretion system (TTSS) encoded by Salmonella pathogenicity island 1 (SPI1) that were previously shown to be necessary for Salmonella invasion. In addition to the role of the Trk transporter in the pathogenesis of Salmonella, we discovered that external K+ modulates the pathogenic properties of Salmonella by increasing the expression and secretion of effector proteins of the SPI1-encoded TTSS and by enhancing epithelial cell invasion. Our studies demonstrated that K+ is actively involved in the pathogenesis of Salmonella and indicated that Salmonella may take advantage of the high K+ content inside host cells and in the intestinal fluid during diarrhea to become more virulent.

scholarly journals Exposure to Rumen Protozoa Leads to Enhancement of Pathogenicity of and Invasion by Multiple-Antibiotic-Resistant Salmonella enterica Bearing SGI1

2005 ◽  
Vol 73 (8) ◽  
pp. 4668-4675 ◽  
Author(s):  
Mark A. Rasmussen ◽  
Steve A. Carlson ◽  
Sharon K. Franklin ◽  
Zoe P. McCuddin ◽  
Max T. Wu ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Recovery Rate ◽  
Salmonella Enterica ◽  
Phage Type ◽  
Infection Model ◽  
Rapid Progression ◽  
Invasion Assay ◽  
Antibiotic Resistant ◽  
Food Borne ◽  
Progression Of Disease

ABSTRACT Multiple-antibiotic-resistant Salmonella enterica serotype Typhimurium is a food-borne pathogen that has been purported to be more virulent than antibiotic-sensitive counterparts. The paradigm for this multiresistant/hyperpathogenic phenotype is Salmonella enterica serotype Typhimurium phage type DT104 (DT104). The basis for the multiresistance in DT104 is related to an integron structure designated SGI1, but factors underlying hyperpathogenicity have not been completely identified. Since protozoa have been implicated in the alteration of virulence in Legionella and Mycobacterium spp., we attempted to assess the possibility that protozoa may contribute to the putative hypervirulence of DT104. Our study reveals that DT104 can be more invasive, as determined by a tissue culture invasion assay, after surviving within protozoa originating from the bovine rumen. The enhancement of invasion was correlated with hypervirulence in a bovine infection model in which we observed a more rapid progression of disease and a greater recovery rate for the pathogen. Fewer DT104 cells were recovered from tissues of infected animals when protozoa were lysed by preinfection chemical defaunation of the bovine or ovine rumen. The protozoan-mediated hypervirulence phenotype was observed only in DT104 and other Salmonella strains, including serovars Agona and Infantis, possessing SGI1.

Deciphering the role of ttrA and pduA genes for Salmonella enterica serovars in a chicken infection model

2021 ◽  
pp. 1-41
Author(s):  
MMS Saraiva ◽  
LB Rodrigues Alves ◽  
DFM Monte ◽  
TS Ferreira ◽  
VP Benevides ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Infection Model

scholarly journals Erratum Erratum to: Salmonella enterica serovar Typhi H58 clone has been endemic in Zimbabwe from 2012 to 2019

2021 ◽  
Author(s):  
Tapfumanei Mashe ◽  
Pimlapas Leekitcharoenphon ◽  
Sekesai Mtapuri-Zinyowera ◽  
Robert A Kingsley ◽  
V Robertson ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi
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