scholarly journals Erratum Erratum to: Salmonella enterica serovar Typhi H58 clone has been endemic in Zimbabwe from 2012 to 2019

2021 ◽  
Author(s):  
Tapfumanei Mashe ◽  
Pimlapas Leekitcharoenphon ◽  
Sekesai Mtapuri-Zinyowera ◽  
Robert A Kingsley ◽  
V Robertson ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi

scholarly journals First Canadian Salmonella enterica Serovar Typhi Isolate Harboring an Integron

2004 ◽  
Vol 48 (2) ◽  
pp. 689-690 ◽  
Author(s):  
Michael R. Mulvey ◽  
Shirley Brown ◽  
Philip Stuart ◽  
David Boyd ◽  
Lai-King Ng ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhi

The malS-5′UTR regulates hisG, a key gene in the histidine biosynthetic pathway in Salmonella enterica serovar Typhi

2017 ◽  
Vol 63 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Ying Zhang ◽  
Dongmei Yan ◽  
Lin Xia ◽  
Xin Zhao ◽  
George Osei-Adjei ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Rna Structure ◽  
Biosynthetic Pathway ◽  
Salmonella Typhi ◽  
Base Pairing ◽  
Salmonella Enterica Serovar Typhi ◽  
Cellular Processes ◽  
Invasive Capacity ◽  
Shine Dalgarno Sequence ◽  
Bax Gene

Bacterial noncoding RNAs (ncRNA) regulate diverse cellular processes, including virulence and environmental fitness. The malS 5′ untranslated region (named malS-5′UTR) was identified as a regulatory ncRNA that increases the invasive capacity of Salmonella enterica serovar Typhi. An IntaRNA search suggested base pairing between malS-5′UTR and hisG mRNA, a key gene in the histidine biosynthetic pathway. Overexpression of malS-5′UTR markedly reduced bacterial growth in minimal medium without histidine. Overexpression of malS-5′UTR increased mRNA from his operon genes, independently of the bax gene, and decreased HisG protein in Salmonella Typhi. RNA structure analysis showed base pairing of the malS-5′UTR RNA with the hisG mRNA across the ribosome binding site. Thus, we propose that malS-5′UTR inhibited hisG translation, probably by base pairing to the Shine–Dalgarno sequence.

scholarly journals Emergence of Resistance Mutations in Salmonella enterica Serovar Typhi Against Fluoroquinolones

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Takashi Matono ◽  
Masatomo Morita ◽  
Koji Yahara ◽  
Ken-ichi Lee ◽  
Hidemasa Izumiya ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Evolutionary Process ◽  
Resistance Mechanisms ◽  
Single Mutation ◽  
Nucleotide Polymorphisms ◽  
Resistance Mutations ◽  
Single Nucleotide ◽  
Salmonella Enterica Serovar Typhi ◽  
Resistant Strains ◽  
Emergence Of Resistance

Abstract Background Little is known about the evolutionary process and emergence time of resistance mutations to fluoroquinolone in Salmonella enterica serovar Typhi. Methods We analyzed S. Typhi isolates collected from returned travelers between 2001 and 2016. Based on ciprofloxacin susceptibility, isolates were categorized as highly resistant (minimum inhibitory concentration [MIC] ≥ 4 μg/mL [CIPHR]), resistant (MIC = 1–2 μg/mL [CIPR]), intermediate susceptible (MIC = 0.12–0.5 μg/mL [CIPI]), and susceptible (MIC ≤ 0.06 μg/mL [CIPS]). Results A total of 107 isolates (33 CIPHR, 14 CIPR, 30 CIPI, and 30 CIPS) were analyzed by whole-genome sequencing; 2461 single nucleotide polymorphisms (SNPs) were identified. CIPS had no mutations in the gyrA or parC genes, while each CIPI had 1 of 3 single mutations in gyrA (encoding Ser83Phe [63.3%], Ser83Tyr [33.3%], or Asp87Asn [3.3%]). CIPHR had the same 3 mutations: 2 SNPs in gyrA (encoding Ser83Phe and Asp87Asn) and a third in parC (encoding Ser80Ile). CIPHR shared a common ancestor with CIPR and CIPI isolates harboring a single mutation in gyrA encoding Ser83Phe, suggesting that CIPHR emerged 16 to 23 years ago. Conclusions Three SNPs—2 in gyrA and 1 in parC—are present in S. Typhi strains highly resistant to fluoroquinolone, which were found to have evolved in 1993–2000, approximately 10 years after the beginning of the ciprofloxacin era. Highly resistant strains with survival advantages arose from strains harboring a single mutation in gyrA encoding Ser83Phe. Judicious use of fluoroquinolones is warranted to prevent acceleration of such resistance mechanisms in the future.

scholarly journals Salmonella enterica serovar Typhi and gallbladder cancer: a case–control study and meta‐analysis

2016 ◽  
Vol 5 (11) ◽  
pp. 3310-3235 ◽  
Author(s):  
Jill Koshiol ◽  
Aniela Wozniak ◽  
Paz Cook ◽  
Christina Adaniel ◽  
Johanna Acevedo ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Salmonella Enterica ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Salmonella Enterica Serovar Typhi ◽  
Control Study
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