Expression and sequence diversity of the complement regulating outer surface protein E in Borrelia afzelii vs. Borrelia garinii in patients with erythema migrans or neuroborreliosis

2010 ◽  
Vol 49 (6) ◽  
pp. 363-368 ◽  
Author(s):  
Jaana Panelius ◽  
Annamari Ranki ◽  
Taru Meri ◽  
Ilkka Seppälä ◽  
Seppo Meri
Keyword(s):  
Outer Surface ◽  
Erythema Migrans ◽  
Surface Protein ◽  
Sequence Diversity ◽  
Borrelia Garinii ◽  
Borrelia Afzelii ◽  
Outer Surface Protein

scholarly journals Four Clones of Borrelia burgdorferiSensu Stricto Cause Invasive Infection in Humans

1999 ◽  
Vol 67 (7) ◽  
pp. 3518-3524 ◽  
Author(s):  
Gerald Seinost ◽  
Daniel E. Dykhuizen ◽  
Raymond J. Dattwyler ◽  
William T. Golde ◽  
John J. Dunn ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Outer Surface ◽  
Systemic Disease ◽  
Erythema Migrans ◽  
Surface Protein ◽  
Sensu Stricto ◽  
Tick Bite ◽  
Invasive Infection ◽  
Frequency Distributions ◽  
Outer Surface Protein

ABSTRACT Lyme disease begins at the site of a tick bite, producing a primary infection with spread of the organism to secondary sites occurring early in the course of infection. A major outer surface protein expressed by the spirochete early in infection is outer surface protein C (OspC). In Borrelia burgdorferi sensu stricto, OspC is highly variable. Based on sequence divergence, alleles ofospC can be divided into 21 major groups. To assess whether strain differences defined by ospC group are linked to invasiveness and pathogenicity, we compared the frequency distributions of major ospC groups from ticks, from the primary erythema migrans skin lesion, and from secondary sites, principally from blood and spinal fluid. The frequency distribution of ospC groups from ticks is significantly different from that from primary sites, which in turn is significantly different from that from secondary sites. The major groups A, B, I, and K had higher frequencies in the primary sites than in ticks and were the only groups found in secondary sites. We define three categories of major ospC groups: one that is common in ticks but very rarely if ever causes human disease, a second that causes only local infection at the tick bite site, and a third that causes systemic disease. The finding that all systemicB. burgdorferi sensu stricto infections are associated with four ospC groups has importance in the diagnosis, treatment, and prevention of Lyme disease.

scholarly journals Rapid outer-surface protein C DNA tattoo vaccination protects against Borrelia afzelii infection

Gene Therapy ◽  
2014 ◽  
Vol 21 (12) ◽  
pp. 1051-1057 ◽  
Author(s):  
A Wagemakers ◽  
L M K Mason ◽  
A Oei ◽  
B de Wever ◽  
T van der Poll ◽  
...  
Keyword(s):  
Outer Surface ◽  
Protein C ◽  
Surface Protein ◽  
Borrelia Afzelii ◽  
Outer Surface Protein
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