Profiling the humoral immune response to Borrelia burgdorferi infection with protein microarrays

2008 ◽  
Vol 45 (5-6) ◽  
pp. 403-407 ◽  
Author(s):  
Yun Xu ◽  
John F. Bruno ◽  
Benjamin J. Luft
Keyword(s):  
Immune Response ◽  
Borrelia Burgdorferi ◽  
Humoral Immune Response ◽  
Protein Microarrays ◽  
Humoral Immune

scholarly journals Use of Protein Microarrays To Define the Humoral Immune Response in Leprosy Patients and Identification of Disease-State-Specific Antigenic Profiles

2006 ◽  
Vol 74 (11) ◽  
pp. 6458-6466 ◽  
Author(s):  
Nathan A. Groathouse ◽  
Amol Amin ◽  
Maria Angela M. Marques ◽  
John S. Spencer ◽  
Robert Gelber ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Protein Microarrays ◽  
Therapeutic Strategies ◽  
Response Patterns ◽  
Protein Antigens ◽  
Humoral Immune ◽  
Large Numbers ◽  
Optimal Drug ◽  
Leprosy Patients

ABSTRACT Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread disease and the effects of chemotherapy on the overall incidence of leprosy. This can partially be attributed to the lack of diagnostic markers for different clinical states of the disease and the consequent implementation of differential, optimal drug therapeutic strategies. Accordingly, comparative bioinformatics and Mycobacterium leprae protein microarrays were applied to investigate whether leprosy patients with different clinical forms of the disease can be categorized based on differential humoral immune response patterns. Evaluation of sera from 20 clinically diagnosed leprosy patients using native protein and recombinant protein microarrays revealed unique disease-specific, humoral reactivity patterns. Statistical analysis of the serological patterns yielded distinct groups that correlated with phenolic glycolipid I reactivity and clinical diagnosis, thus demonstrating that leprosy patients, including those diagnosed with the paucibacillary, tuberculoid form of disease, can be classified based on humoral reactivity to a subset of M. leprae protein antigens produced in recombinant form.

Role of Yersinia pseudotuberculosis outer proteins (Yops) in murine humoral immune response

2009 ◽  
Vol 54 (3) ◽  
pp. 239-245 ◽  
Author(s):  
J. M. L. Maia ◽  
L. G. S. Monnazzi ◽  
B. M. M. Medeiros
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Yersinia Pseudotuberculosis ◽  
Humoral Immune

scholarly journals Diagnostic and analytical performance evaluation of ten commercial assays for detecting SARS-CoV-2 humoral immune response

2021 ◽  
pp. 113043
Author(s):  
Marnix Mylemans ◽  
Eveline Van Honacker ◽  
Louis Nevejan ◽  
Stefanie van den Bremt ◽  
Laura Hofman ◽  
...  
Keyword(s):  
Immune Response ◽  
Performance Evaluation ◽  
Humoral Immune Response ◽  
Analytical Performance ◽  
Humoral Immune
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