scholarly journals An experimental strategy for quantitative analysis of the humoral immune response to prostate cancer antigens using natural protein microarrays

2007 ◽  
Vol 1 (5) ◽  
pp. 494-505 ◽  
Author(s):  
Sara Forrester ◽  
Ji Qiu ◽  
Leslie Mangold ◽  
Alan Partin ◽  
David Misek ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Quantitative Analysis ◽  
Humoral Immune Response ◽  
Protein Microarrays ◽  
Humoral Immune ◽  
Experimental Strategy ◽  
Natural Protein ◽  
Cancer Antigens

scholarly journals Use of Protein Microarrays To Define the Humoral Immune Response in Leprosy Patients and Identification of Disease-State-Specific Antigenic Profiles

2006 ◽  
Vol 74 (11) ◽  
pp. 6458-6466 ◽  
Author(s):  
Nathan A. Groathouse ◽  
Amol Amin ◽  
Maria Angela M. Marques ◽  
John S. Spencer ◽  
Robert Gelber ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Protein Microarrays ◽  
Therapeutic Strategies ◽  
Response Patterns ◽  
Protein Antigens ◽  
Humoral Immune ◽  
Large Numbers ◽  
Optimal Drug ◽  
Leprosy Patients

ABSTRACT Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread disease and the effects of chemotherapy on the overall incidence of leprosy. This can partially be attributed to the lack of diagnostic markers for different clinical states of the disease and the consequent implementation of differential, optimal drug therapeutic strategies. Accordingly, comparative bioinformatics and Mycobacterium leprae protein microarrays were applied to investigate whether leprosy patients with different clinical forms of the disease can be categorized based on differential humoral immune response patterns. Evaluation of sera from 20 clinically diagnosed leprosy patients using native protein and recombinant protein microarrays revealed unique disease-specific, humoral reactivity patterns. Statistical analysis of the serological patterns yielded distinct groups that correlated with phenolic glycolipid I reactivity and clinical diagnosis, thus demonstrating that leprosy patients, including those diagnosed with the paucibacillary, tuberculoid form of disease, can be classified based on humoral reactivity to a subset of M. leprae protein antigens produced in recombinant form.

scholarly journals Humoral Immune Response to  -Methylacyl-CoA Racemase and Prostate Cancer

2004 ◽  
Vol 96 (11) ◽  
pp. 834-843 ◽  
Author(s):  
A. Sreekumar ◽  
B. Laxman ◽  
D. R. Rhodes ◽  
S. Bhagavathula ◽  
J. Harwood ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Humoral Immune Response ◽  
Humoral Immune

Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens

The Prostate ◽  
2005 ◽  
Vol 63 (3) ◽  
pp. 252-258 ◽  
Author(s):  
Fu-Dong Shi ◽  
Jian-Ying Zhang ◽  
Daorong Liu ◽  
Ann Rearden ◽  
Max Elliot ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Humoral Immune Response ◽  
Cellular Proteins ◽  
Tumor Associated Antigens ◽  
Humoral Immune
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